peroxidation la egyahay (Lpo) waa link muhiim ah in is-dhaafsiga dheefshiidka. Shaqada aasaasiga ah waxaa ka mid ah waa inaad cusboonaysiiso u subaga ee xuubka unug.
In peroxidation qof la egyahay caafimaad gacanta ee loo yaqaan nidaamka antioxidant oo dejisa hawl xawaaraha iyo phosphorylation ah by qabanaya arrimaha xanaajiyey ama takhalusi lahaayeen tiro ku filan oo peroxides si looga hortago in loo badin ah alaabta dhamaadka shiid. habka lagu qayilo weyneeye laga yaabaa barta laga bilaabo geedi socodka pathophysiological cudurada xaddi weyn. Hawlgalkani waxa ka mid ah tallaabo of enzymatic iyo autoxidation non-enzymatic.
noocyada
Inuu wax ka beddelo bilayer ku phospholipid of xuub gacanta u waasiciyo qayilo enzymatic. Intaa waxaa dheer, waxaa ku lug leh formation of walxaha bayoloji firfircoon, naanin, reactions dheefshiidka. qayilo Non-enzymatic ma muuqato sida factor burbur nolosha unugyada. Sababo la formation of xaddi badan oo xagjirka lacag la'aan iyo hoos u dhaqdhaqaaqa nidaamka peroxides antioxidant raasamaal iyo sida natiijo ah, waxaa jira burburka unugyada u shaqeeyo.
PAUL wareegga
Si aad u bilowdo peroxidation la egyahay joogaan lagama maarmaan ah oxygen xagjirka lacag la'aan, isagoo heerka tamarta ee xad-dhaaf ah mid electron ku unpaired ah. Ka dib markii dib u soo kabashada ee u taagoo oxygen soo saaray superoxide oo sameynayso la atamka hydrogen, bedalayo hydrogenperoxid ah. Xakameeyo cadadka superoxide gudaha unugyada jira dismutase superoxide, la xirrira hydrogenperoxid iyo catalase, perodoxida waxay uga takhalusi lahaayeen in ay biyo. Haddii shaqeeyo nool ayaa waxaa soo if-ionizing shucaaca, tirada xag hydroxyl free kordhin doonaa si weyn. Intaas waxaa sii dheer oxygen hydroxide iyo noocyo kale oo firfircoon ay bilaabi karaa habraaca xawaaladaha ee peroxidation la egyahay ah.
Products of peroxidation la egyahay ama u shaqeeyo takhalusin, ama loo isticmaalo ereygu wuxuu ahaa ee prostaglandins (walxaha ku lug reactions barar), thromboxanes (waxaa ka mid ahaa Cascade thrombogenic of reactions), hormoonnada adrenal.
nidaamka xakamaynta
Iyadoo ku xiran xawaaraha xuub gacanta saldhig qaab-dhismeedka, iyo qaddarka waxqabad oo ka mid ah waxyaabaha lagu qayilo keentay kala duwanaan karaan. Tusaale ahaan, waxqabadka of subaga peroxidation kor halkaas oo qayb ka mid ah derbiga unug Dadwaynaha acids dufan roodhida, iyo gaabis ah, haddii saleysan COP waa kolestaroolka. Intaa waxaa dheer, arrin xakameeyo cadadka iyo heerka of formation of xag oxygen free, iyo sidoo kale isticmaalka peroxides, waa ensaymes dheefshiidka. Xataa falcelinta ee subaga peroxidation ka qayb walxaha saamayn ku kooban xuub gacanta la egyahay iyo isbedel aan sabab lahayn oo waafaqsan baahida u shaqeeyo. Waxaa ka mid ah vitamin E iyo K, tyroksiini (hormone thyroid), hydrokortisoni, cortisone iyo aldosterone (of-celin). udhigo biraha derbiga unug xasilloni, fitamiinada C iyo D.
xad gudub ku ah geedi socodka
alaabta dheefshiidka ee peroxidation la egyahay uruursado laga yaabaa in unugyada iyo dheecaannada jidhka haddii nidaamka antioxidant uusan tuurin iyaga ka mid ah oo leh xawaare lagama maarmaanka ah. Sidaas awgeed carqaladeeyey gaadiidka ee atammada guud ahaan xuub gacanta, taas oo si dadban saamayn ku yeelan karaan ka kooban Madbacada qaranka ee qaybta hooraha ee dhiigga, heerka of kala fogaansho iyo depolarization of xuub gacanta muruqa (jebin tabinta ah falalkooda dareemayaasha, ay contractility, dheereynaya muddada madax adkaadeen), fududeeyo soo galo dheecaan galay meesha bannaan ee extracellular (oedema, xinjiro dhiig, dheelitir la'aanta elektrolytka). Intaa waxaa dheer, wax soo saarka ugu weyn ee peroxidation la egyahay, ka dib markii taxane ah oo reactions lagmamaarmaanna, waxaa diinta aldehydes, ketones, acids iyo si bixi. Waxyaabahani waxay leeyihiin saamayn sun ah oo jidhka ah, taas oo u muuqato in heerka hoos u of Avv DNA ah, la kordhiyo permeability gaddoonka ah, la kordhiyo cadaadiska oncotic, sida sidaas awgeed, daaalo-syndrome.
Eebbe ee rugta caafimaadka
Tan iyo kororka xagjiriinta oxygen free leedahay waxyeelo derbiga unug, iyo wax soo saarka dheef-shiid carqaladeeyo iyo Avv acids nucleic iyo sunta jidhka, iyagu waa arrin pathophysiologic in horumarinta tiro ka mid ah xaaladaha caafimaad. Doorka peroxidation la egyahay ee beerka waa cudur muhiim ah oo ka mid ah kala-goysyada, cudurrada dulinka faafa, cudurada hemodynamic, cudurada oncological, kuwa dhimirka iyo gubasho. Pol waa mid ka mid ah sababaha for atherosclerosis. xag Free oxidize kolestaroolka iyo miisaanka kelli hooseeyo ay jajabka si ay u sameeyaan waxyaabaha dhaawici derbiga vascular. Tani waxay ka bilaabataa Cascade ah reactions bahal caadiga ah si wax looga qabto burburka. Tani dhirfinaya xinjiro dhiig, raasamaal ee xinjiro dhiig ku Lumen, oo weelasha yaryar ama lifaaqa in nimankaas derbiyadooda. Sidaas darteed dhaqdhaqaaqa dhiigga ee ku yaala goobahan caanuhu, sida uu horey u noqdaan a Lumen weel. Taasina waxay keentaa in ay raasamaal dheeraad ah xinjiro dhiig. The ugu nugul isbedelada sida in halbowleyaasha wadnaha, quseyo, muujiyey in calaamadaha rugta cudurka halboowlayaasha wadnaha.
tallaabooyinka ka hortagga
Practitioners waa in la xasuusto in dhaqanka nidaamka baaritaanka iyo daweynta dhaqaajiso karaa hab ay of peroxidation la egyahay. Tani waa digo bukaanka. By iska xanaajin qodobo ka mid ah daawaynta shucaaca (kansarka), iftiinka ultraviolet (la rickets, cudurada bararka ee u furani, qolalka daaweynta bakteeriyada), beeraha magnetic (MRI, CT, daaweynta jirka) kal-fadhi qowlad hyperbaric (ee dabeysha, bukaanka sare).
Ka Hortagga iyo Daaweynta
Shaqaalaha ka shaqeeya rentgenkabinetom, Orderlies iyo kalkaalisooyinka, ku takhasusay daaweynta dabiiciga ah, Mountaineers, dadka qaba miisaan xad-dhaaf aad u baahan tahay in la cuno cuntada ay ku jirto antioksidanter dabiiciga ah: kalluunka, gabbaldayaha ama saliid saytuun ah, iyo geedo yaryar, ukunta, shaaha cagaaran. Waxa intaa dheer in la beddelo cuntada, daawooyinka la isticmaali karaa xidho in kooxo gaar ah ama xag lacag la'aan ah lagu biiriyo biraha of valency variable. Oo saasna waxay lacag la'aan u taagoo oxygen firfircoon taagan, iyaga ka qabanaya in Sammeecado peroxidation la egyahay.
Baadhista xanuunada
Marka marxaladdan hadda ee horumarinta cilmi-baarista shaybaarka waxaan awoodnaa in lagu ogaado waxaay sheegayaan in sidiisa oo cabitaan ah noolaha ee jidhka bini'aadamka. Si arrintan loo sameeyo, fuliyaan microscopy fluorescence. Si fudud u gelin, si ay u aqoonsadaan peroxidation la egyahay ah. Qiimaha imtixaanka baadhitaan u baahan sharaxaad no. Indeed, in cudurka xaddiga la taaban karo ku salaysan waa hawl-dhaafka ah ee peroxidation la egyahay. Ogaanshaha ee gobolka this go'aamiyo daaweynta.
Marka laga eego dhinaca jirka caadiga ah ee peroxidation la egyahay waa lagama maarmaan u ah formation of hormoonnada steroid, dhexdhexaadiyayaal bararka, cytokines iyo thromboxanes. Laakiin marka tirada alaabta kiimikada xogta reactions sarrifka ka badan qiimaha iyo dhaawac waxaay sheegayaan organelles cell la ogolyahay, DNA iyo carqaladeeyo ereygu wuxuu ahaa ee brotiin, dhaqan galo nidaamka antioxidant in yaraynaysaa qadarka xag oxygen xor ah oo udhigo biraha la valency variable. Intaa waxaa dheer, u kordhiyaa ereygu wuxuu ahaa ee catalase iyo perodoxida for asturidda peroxides iyo waxyaabaha ay shiid dheeraad ah xad-dhaaf ah.