Hydrochloride epinephrine: tilmaamaha loo isticmaalo, sharaxaad ku saabsan diyaarinta

hoos u dhac A fiiqan ee cadaadiska dhiigga sabab u ah xasaasiyad, dhaafka ah daawo ama sababo kale waxay keeni kartaa cawaaqib karin ee jidhka iyo xitaa dhimasho. Si aad u taariikhda, dhaqanka ee dawada si loo soo saaro bukaanka gobolka this waxaa loo isticmaalaa hydrochloride adrenaline. Waxaa, iyada oo ku xiran kakanaanta xaaladda, bukaanka waxaa subcutant maamula, intramuscularly ama faleebo, iyo in xaaladaha ugu daran - intracardiac.

saamaynta pharmacological

Saamaynta ugu weyn ee daroogada si toos ah oo la xidhiidha saamaynta on a- iyo b-adrenergic receptors ah, oo siyaabo badan waxa ay la mid tahay saamaynta excitation fiber dareemayaasha. Marka ay maamusho ay u hydrochloride epinephrine kor u vasoconstriction dhan xubnaha caloosha iyo muruqyada oo qayb ahaan lafaha. Sababo la xiriira hoos u sida in channels dhiig Lumen dhacdaa korodhka cadaadiska dhiigga.

Si kastaba ha ahaatee, waxaa la ogaadaa in saamaynta saamayn adrenalin ah oo jidhka ah, ay sabab u tahay saamaynta ay ku receptors b-adrenergic ah, ka yar si joogto ah la barbar dhigo noradrenaliin. dabeecadda iskujoog oo dhaqdhaqaaqa wadnaha waa mid aad u adag. Ka dib markii kicinta ee receptors adrenergic kordhinayaan in garaaca wadnaha inta badan soo noqnoqda oo kor u kacay, iyo waqti isku mid ah, marka cadaadiska dhiigga ka soo baxdo, xarunta waa dareemaha vagus faraxsanahay, taas oo uu hakiyo shaqada ee wadnaha. Taasi waa sababta inta lagu guda jiro hypoxia maamulka daroogada waxay keeni kartaa arrhythmia.

Intaa waxaa dheer, daroogada sababa furanto ardayga, nasashada ee muruqyada oo ka mid ah xiidmaha iyo hawomareenno. Waxaa caddeeyeen in bukaannada loo dadajinaya-shiid nudaha iyo kor u kacda glucose dhiiga ku jira ka dib markii dhoos keli ah qalab sida hydrochloride epinephrine. Tilmaamaha loogu isticmaalo iyo waxa ku jira macluumaad ku saabsan dawo soo celinayo awoodda functional of unugyada muruqa lafaha, oo ay ku jiraan la daal.

Iyadoo la tixgelinayo qaabka dareenka dhexe, qiyaasta ku daweyn of daroogada, sida caadiga ah, ma leeyihiin saamayn fahmayaan waxa on.

Si ay u muujiyaan daroogada?

Isticmaalka hydrochloride epinephrine la hoos u dhac af ee cadaadiska dhiigga (xaalad caafimaad sida bukaanka loo yaqaan burburkii). Kac dhibaatooyinka noocan oo kale ah waxay keeni kartaa in daawo aadanaha xad dhaafka ah, qaniinyada cayayaanka iyo cadaanyo ba'an.

tilmaan kale ee daroogada - hypoglycemia, taas oo uu dhacaa marka badinta of insulin. In gobolka this, bukaanka waxaa si degdeg ah hoos u cadaadiska dhiigga waxqabadka ma aha oo kaliya, laakiin sidoo kale heerka sonkorta dhiigga.

In indhaha daawada laguu qoray in bukaanka qaba kordhay cadaadiska intraocular (glaucoma). In dhaqanka ENT waxaa loo isticmaalaa sida vasoconstrictor ah.

Waxa intaa dheer in muujinaya kuwan, hydrochloride epinephrine waxaa maamula in bukaanka qaba aamba ventricular.

nidaamka kacmaha iyo habka isticmaalka

Iyadoo ku xiran cudurka iyo daroogada saxariirinta bukaanka subcutant Lagu arki karo, intramuscularly iyo intravenously. Sayidka isticmaalaya xal of 0.1% 0.2 / 0.3 / 0.5 ama 1 ml. Bukaanka qaba wadnaha ba'an ay maamusho 1 ml of diyaarinta, qiyaas la mid ah waxaa loo isticmaalaa, iyo aamba ventricular. Waa in la ogaadaa in circuit dawada ay doorteen oo kaliya dhakhtar ee kiis kasta.

In indhaha loo gaaro waxtarka vasoconstrictive maxaliga ah ee hydrochloride epinephrine waxaa laga codsadaa in ay xub-axaleedka ee isha.

neefta bronki jaray subcutant maamulka daroogada ee 0.3 - 0.5 - 0.7 ml. Laakiin sida qaadasho ku daweyn of xal epinephrine si loogu isticmaalo parenteral, ka dibna, sida caadiga ah, ay la diyaariyey, waayo, bukaanada qaangaarka ah 0.3 - 0.5 - 0.75 ml. Babe, haddii loo baahdo codsiga ah ee medicament this sida ay da'doodu ka waxaa maamula 0.1-0.5 ml.

Halabuurka The daroogada

hydrochloride epinephrine qaab saafi ah waa budo crystalline wax yar casaan ama caddaan. Under saameynta ay oxygen iyo Nuur waxa uu awoodaa in wax laga beddelo. Si kastaba ha ahaatee, qaab sida, diyaarinta aan bixisey in macaamilka. Ka hor waxa loo isticmaali karaa in dhaqanka caafimaad ee xaaladaha aseptic ee warshadaha dawooyinka waxaa qasi jiray xal of Aashito. In la isticmaalo farmashiistayaasha sida sheyga metabisulphite sodium iyo chlorobutanol.

Kaliya ka dib farmasiyada, bukaanka u bartaan laga yaabaa in xal hydrochloride epinephrine, si buuxda diyaar u ah in loo isticmaalo.

foomka Release of daroogada

Si aad u taariikhda, daroogada waxaa laga heli karaa oo kaliya in ay macaamiisha ee foomka of xal 0.1% taas oo lagu heli karaa fijaan oo ampoules. Volume First of 30 ml, laakiin labaad - 1 kaliya ml. Ampoules of 6 kumbiyuutarada. baakadeeyey sanduuqa kartoonka.

In muuqaalka u eg xalka gabi ahaanba waa dareere ah oo hufan, soo dadajin lahayn iyo xubno nerastvoronnyh kala duwan.

daroogada Tani waa u?

Haddii aan ka fiirsan in ay calaamad ugu weyn ee isticmaalka daroogada - korodhka cadaadiska dhiigga oo ay sabab u cidhiidhi ah xididdada dhiigga, waa macquul in ay gabi ahaanba looma isticmaali karo in bukaanka hypertensive. Sidoo kale macnaheedu waa mamnuuc at atherosclerosis, tayroodh iyo cudurka macaanka, sababtoo ah saamaynta pharmacological daroogada ma sii dari kartaa oo keliya inta lagu guda jiro nno kor ku xusan, laakiin sidoo kale keeni cawaaqib aad u khatar ah. Tusaale ahaan, Wadnaxanuun myocardial, stroke iyo kuwa kale.

Ma hydrochloride epinephrine lagu dabaqi karo iyo inta lagu jiro qalliin, cyclopropane ama suuxdinta halothane.

Sidoo kale waa in la ogaadaa in daawadu ay gebi ahaanba la mamnuucay xilliga uurka iyo nuujinta. Iyo in lala daroogada "oxytocin" daroogada keenaysaa in sumoobo kordhay.

waxyeellooyin

In kasta oo xaqiiqda ah in cudurro badan oo daroogada waxay badbaadin kartaa nolosha qofka bukaanka ah, sida ay u badan tahay, oo u dhimi kartaa haddii aadan tixgeliyaan ah sifooyinka gaarka ah ee bukaan-socodka ama ka badan qiyaasta la ogolyahay.

Sidaas daraaddeed, xitaa marka si habboon loo isticmaalo, daawada qof dareemi kartaa wareer, welwel, gariir, walaaca iyo tabar guud. Intaa waxaa dheer, bukaan ka dib markii maamulka daroogada oo laga dheehan karo doorsoonka (sabab u vasoconstriction), dhidid iyo kororka transient in cadaadiska dhiigga. Si kastaba ha ahaatee, calaamadaha xun, sababta oo ah muddo gaaban, oo aan u baahnayn saxo caafimaad ama la baabiiyo dhamaystiran oo daroogada.

Kuwa hydrochloride adrenaline muujiyay, diiwaanka ka digay ku saabsan horumarka ay suurtagal tahay baarutaan wadnaha, tachycardia, kaca fiiqan ee cadaadiska dhiigga. In bukaanka qaba cudurka halbowlaha wadnaha isticmaala daroogada wuxuu kordhiyaa khatarta weeraro angina.

badinta

Qof walba waa ogyahay in daawooyinka daawo la filayaa in loo isticmaalo in qiyaasta saxda ah oo kaliya on qoro. Haddii kale, caafimaadka bukaan-socodka waa in khatar qabriga. Oo hydrochloride epinephrine ma aha marka laga reebo ah.

Marka aad iyo aad xalka qiyaasta la ogolaan karo (xitaa marka subcutant maamula) qofka bukaanka ah isla markiiba si degdeg ah uu yeesho mydriasis oo kordhay cadaadiska dhiigga. Intaa waxaa dheer, si weyn u nooleeyaa garaaca wadnaha, taas oo mararka qaarkood gudbaan aamba ventricular. Oo haddii bukaanku si xoog leh loo kordhiyo cadaadiska hydrostatic ee xididdada dhiigga yar iyo permeability derbiga iyo gaddoonka pulmonary, waxa dhici karta in unugyada barar sambabada.

Sidee ku xakameynayaan saamaynta xun ee daroogada?

Kooxda dhibtooneysa ee la tiro ka mid ah falalka gurracan ee adrenalin antagonistically simaha via α- iyo β-blockers. Waxaa ka mid ah daroogada "Inderal" "Tropafen", "Phentolamine" iyo kuwa kale. Inta badan dhakhaatiirta si loo soo saaro saamaynta adrenaline iyo isticmaalka dhakhso nitrites. Si kastaba ha ahaatee, isticmaalka kooxaha kor ku xusan ee daawooyinka waa ansax ah oo keliya marka iftiinka foomamka taxane ah oo waxyeelo ka dhigan sida hydrochloride adrenaline (formula waa: 1-1- (3,4-dihydroxyphenyl) hydrochloride -2-methylaminoethanol).

Haddii bukaanka marka la isticmaalayo daroogada this arkay dhibaatooyinka sii daran sida aamba ventricular ama barar sambabada ballaaran, codsiga-xawaaraha sare ee nitrite iyo blockers kala duwan oo ku filan. Waayo, badbaadinta dadka bukaanka ah ee kiisaskan, dhakhaatiirta ayaa ansixiyay therapy adag, taas oo ka mid noqon kara xitaa Rogidda koronto ee wadnaha.

Xaaladaha of sahayda of daroogada

Waxaa keliya oo macquul ah in daawada waa daawo ku salaysan adrenaline mamnuucayaa free inay iska iibiso si user dhamaadka. Ka dib is dhigan tahay xogta keeni kartaa miisanka cawaaqib xun xitaa la waafaqsan adag nidaamka raan. Intaa waxaa dheer, qaar ka mid ah bukaanka qaba hordhaca ah ee qadar yar oo ah hydrochloride adrenaline ah (war ka marag furaa in this)-celinta xasaasiyadda daran ayaa dhici kara.

Sidaas ka hor inta aadan aadin farmashiyaha for daawooyinkan, waa in aad la tashato dhakhtar qori doona dawada. Waa this document, taas oo ka kooban macluumaad ku saabsan tirada iyo qiyaasta of daroogada, farmashiistaha waa in la soo bandhigo markii iibsiga dawada.

isdhexgalka daroogada

dhakhtar kasta waa ogyahay in isticmaalka adrenaline la symptomatology kala duwan gebi ahaanba la mamnuucay. Ka dib oo dhan, isku darka noocan oo kale ah uu leeyahay saamayn daro ah oo keenta in loo eedsaday.

Ha isticmaalin daawo this si loogu daweeyo bukaannada qaata kiniinada hurdada oo analgesics maandooriyaha. Intaa waxaa dheer, xasaasiyad, oo si nidaamsan loo isticmaalo daawooyinka xasaasiyadda, dhakhtar kasta, sidoo kale, uu diido in uu qoro warqad. hydrochloride adrenaline kiiskan ma aha oo kaliya halis caafimaad ah - waxaa laga yaabaa dilaa ah.

Lama ogola daroogada isku dhafan oo suuxinta neefsasho ah, maadaama ay tani waxay keeni kartaa in horumarka cudurka wadnaha ee kakan ee bukaan-socodka ah.

analogues daawo

Sababo la xaqiiqada ah in saynisyahano ha joojin on natiijada gaari oo ay sii wadaan in ay ka shaqeeyaan abuurka daroogada cusub ee habka hydrochloride epinephrine waayo, maanta ayaa durbaba liiska cajiib ah analogues. Si kastaba ha ahaatee, doorashada ee daroogada, la mid ah in tallaabo la adrenaline, waxaa lagu fuliyaa si gaar ah uu dhakhtarka xaadirka ah. Xaaladdan oo kale, oo khabiir ku ah waxaa lagu hanuuniyey ma aha oo kaliya foomka iyo adkaanta cudurka bukaanka, laakiin sidoo kale la tixgelinayo sifooyinka gaarka ah.

Bedel dhakhtar hydrochloride epinephrine laga yaabaa daawooyin sida "Epinifrin", "Tonogen", "Glaukozan" "kumbyuutarradeedu hydrochloride" "Suprarenalin" "hydrochloride epinephrine," "Levorenin", "Eppie", "Renostiptitsin", "Suprarenin" "glauconite", "Epirenan", "Adrenamin", "Gipernefrin", "Stiptirenal", "Paranefrin", "Glaukonin" et al.

Inkastoo liiska cajiib ah dhigooda, waa mid aan u malaynayaa in ay noqon karaan si xor ah u iibsadaan farmashiyaha. By iibsiga hydrochloride adrenaline, qoro ee Latin ayaa loo baahan yahay si ay u muujiyaan farmashiistaha. Waxaa la mid ah ayaa loo baahan yahay haddii aad rabto inaad iibsato mid ka mid ah daawooyinka ku xusan.