Daawada "Aspekard": tilmaamaha loo isticmaalo, analogs, dib u eegista

Acetylsalicylic acid (ASA) waxaa loola jeedaa in daawooyinka la saamaynta qandhada, anti-bararka iyo antiplatelet. In dhaqanka caafimaad waxaa loo isticmaalaa in ka badan 125 sano, sababtoo ah waa mid ka mid ah daroogada ee ugu bartay. War sidee ASA hadda waa laga heli karaa sida kardioformy ah si loo yareeyo khatarta thrombosis halbowlaha wadnaha, taas oo caqabad ku ah horumarka Wadnaxanuun myocardial. Tusaale A caadiga ah waa diyaarinta "Aspekard" taas oo ka kooban acetylsalicylic acid in aan fiicnayn dose saamayn antiplatelet ah.

Warbixin ku saabsan foomka sii daayo iyo saaraha

saaraha ee daroogada waa shirkadda Yukreeniyaan "Stirolbiopharm". Iyadoo la raacayo, technology-saarka ah loo isticmaalo, soo saaray in foomamka qaab zheludochnorastvorimoy at dose oo ah 100 mg, halkii kaniini. Hababka kiniin khariidad:

• kartoonka 120 kiniiniyada (10 ilaa 12 finan tab.);
• weelka polymeric 100 kiniin.

Tablet "Aspekard" waxaa ku jira 100 mg ah ASA, cellulose mikrokristallin, sodium croscarmellose, Silicon Kolloidol dioxide, stearic acid.

Talooyin ku ballan

In diyaarinta "Aspekard" codsiga waa cidhiidhi ah oo ku filan, inkasta oo waxa ku jira tilmaamaha ah ee talooyinka loogu daweeyo of cuduro badan, oo ay ku jiraan cudurada rheumatic. Manufacturer talinayaa "Aspekard" iyo sida wakiilka ah qandhada ama xanuunka. Dhab ahaantii, in qiyaasta daawada acetylsalicylic acid kaliya la ool ah loo isticmaali karaa sida daroogada ah oo ka joojinaysa xulkii dhiig xinjirowga.

Tilmaamayaasha "Aspekard"

On diyaarinta "Aspekard" edbinta ku saabsan codsiga, dib u xirfadlayaasha cilmi kiliinikada iyo siiyaan macluumaad badan oo la xiriira antiplatelet therapy. Waxaa la tilmaamay in xaaladahan soo socda:

• marka (taladadii), syndrome coronary ba'an (at Wadnaxanuun myocardial tallaabo qaadis ba'an, niyad-jabka ama dhawrsan meesha qeybta ST, in angina deganayn);
• la stroke (stroke ischaemic ama weerarka transient ischaemic);
• lacala xaqiijiyey cudurka halbowlaha wadnaha iyada oo loo adeegsanayo ka hortaga syndrome coronary ba'an iyo stroke,
• ee ka hortagga dhacdooyin soo noqnoqda ee syndrome coronary ba'an iyo stroke,
• iyadoo ay goobjoog ka ahaayeen xididada qaradhku;
• sida wakiilka ka hortag ah, thrombosis boodo digniin ah ka dib markii CABG;
• la hypertension in ay dhacdo khatar sare wadnaha.

khatarta wadnaha High waa fikradda ah wadar ahaan labada lug ay ku jiraan joogitaanka dhaawac diirada xubin ee hypertension iyo cudurada la xiriira: diabetes mellitus, cudurka halbowlaha wadnaha, TSVB.

Maqaallo daawada qiyaasta lagu taliyey by saaraha

In diyaarinta "Aspekard" edbinta soo saare ma aha hoggaanka ugu weyn ee daaweynta bukaanka. Waxaa ku jira macluumaad ku saabsan maamulka daroogada xaaladaha caafimaad oo kala duwan laga bilaabo ka-hortagga ah ee dhacdooyinka atherothrombotic ee CHD iyo TSVB iyo dhamaanayey xanuunada ba'an ee wareegga cerebral iyo wadnaha. l'waxaa loo arkaa dabeecad kusugan xumo inaan arrinta daroogooyinka iyo la socda qalabka macluumaadka. Waxa kale oo ay abuuri shuruud ee daabacaadan mass of articles, kuwaas oo ka qaadashada talinayaa kala duwan.

Keeneysa in daawada ku salaysan talooyinka caalamiga ah

On ku salaysan xeerarka caalamiga ah ee ay Community Yurub ee Wadnaha (ESC) iyo American Heart Association (Ahaa) oo loo habeeyey by Wasaaradda Caafimaadka, ee hababka codsiga of acetylsalicylic acid waa sida soo socota:

• xaalad degdeg tallaabo lagu jiro ba'an syndrome wadnaha waxaa loo baahan yahay in la siiyo bukaanka si calaliyo Alwaaxdii 3 "Aspekard 100". Tilmaamaha loogu isticmaalo waa indha tiray, iyo qiyaasta hal of 300 mg,
• ischemia chronic wadnaha (CHD) ee soo dhawaynta joogto ah loo xilsaaray hal kiniin oo ah 100 mg fiidkii ka dib markii cashada;
• la hypertension bukaanka waxay leeyihiin halis sare u qaba dhibaatooyinka wadnaha, iyo sidoo kale qaradhku arooriyaha si joogto ah ay qaateen 100 mg (1 kiniin) fiidkii ka dib markii casho.

Siyaabo kale oo ka mid ah maamulka daroogada "Aspekard" ESC edbinta iyo Ahaa ma bixiso. Waxaa kaloo muhiim ah in la ogaado in qiyaasta caadiga ah "Aspekard" waa 100 mg ah ASA. Waayo, ka hortagga cudurada kor ku xusan, iyadoo la raacayo tilmaamaha ESC iyo Ahaa, codsatay dose of 75 mg. Si kastaba ha ahaatee, 100 mg bukaan loo xilsaaray ka dib markii CABG si looga hortago thrombosis ee laga boodo ah. Xaaladaha kale waxaa lagula talinayaa in ay ka dalban 75 mg, i.e. xaddiga ASA, kaas oo bixiya saamayn antiplatelet ku filan oo uu leeyahay gastrotoxicity ah khatarta ugu yar.

Sidoo kale, soo saaraha ma bixiso macluumaad muhiim ah oo ku saabsan la baabiiyo of daroogada. Sida laga soo xigtay tirakoob, joojinta kedis ah Jidka 10.2% ka mid ah dhacdooyinka wadnaha ba'an. Oo iyana waxay ku waxaa laga helaa qiyaas ahaan 10.6 maalmood laga bilaabo taariikhda la joojiyo of ASA ka dib. muddo Tani waa celcelis ahaan iyo ka tarjumaysaa markii ugu taas oo dadka oo dhan waa la dhimay hawlaha cyclooxygenase dhiig xinjirowga. Sidaas darteed, waxaa macquul ah xinjiro dhiig soo celiyo. Sababtoo ah daroogada waa in la joogto ah loo qaaday, halka magacaabista Wakiilka kale antiplatelet halkii "Aspekard" muuqaalka dhibaatooyin ka mareenka caloosha iyo mindhicirka loo baahan yahay.

Sababo "Aspekard" diyaarinta

ammaanka dhammaan dawooyinka waa qaraabo, maxaa yeelay, waxay leeyihiin dhibaatooyin soo raaca. Isla mar ahaantaana ay keeni sababo qaar ka mid ah. Gaar ahaan:

• in cudurada of xinjirowga dhiiga (diathesis hemorrhagic, hemophilia A iyo B);
• in cudurada of sifooyinka caloosha (erosions, boogaha daran ee caloosha iyo mindhicirka yar 12);
• inta lagu jiro bilaha ugu horreeya uurka iyo nuujinta,
• in kelyaha ama cagaarshowga dhantaalan daran;
• marka xasaasiyad ah in salicylates;
• in carruurta ka yar 18 sano;
• iyadoo ay wada joogaan neefta bronki,
• ee daaweynta ee methotrexate.

sababo Kuwanu waa waadaxa ah, inkasta oo markii qaar ka mid ah: nuujinta, uurka, nabaad guurka iyo boogaha of mareenka caloosha iyo mindhicirka, iyo yaraantaadii. Oo weliba waxaa jira koox ka mid ah gobolada, joogitaanka kaas oo u baahan la socosho joogto ah dhakhtar. Tani isticmaalka isku mar ah therapy antiplatelet daawada xinjirowga lidka, iyo daaweynta bukaanka ka dib markii qaliin wadnaha hawlbowlaha dhiigga. Haddii function kelyaha codsatay in ay daroogada "Aspekard" tilmaamaha loo isticmaalo waxay u baahan yihiin hoos u qiyaasta ama buuxi baabiiyo tartiib ah daroogada.

saamaynta Joint "Aspekard"

Acetylsalicylic acid uu leeyahay tiro ka mid ah saamaynta in kor loogu qaado ama ku tuuji tallaabo daroogada dhowr. Gaar ahaan:

• ASA wanaajisaa saamaynta kasta xinjirowga lidka ku ah iyo wakiilada antiplatelet;
• ASA wanaajisaa saamaynta qandhada iyo xanuunka ee NSAIDs, rizqiga saamayn antirheumatic "Meloxicam";
• marka daawooyin cytotoxic isku daro ay wanaajisaa ay gastrotoxicity;
• marka la khamriga halista jahawareerka boog ama dhiig kor u qaaday,
• glucocorticoids gastrotoxicity kordhinta "Aspekard";
• ACK attenuates saamayn lagu durayo marka la diuretics "Furosemide", "torasemide", "spironolactone" marka la isku daro.
• "Aspekard" jilciyaa saamaynta wakiilada uricosuric, "Probenecid", "Etamid", "sulfinpirazon";
• nonabsorbable laabjeexa si weyn u yareeyaan ka nuugista ee "Aspekard".

jaaniska ah qiyaasta xad dhaafka ah iyo calaamadaha ay

Xad daroogada "Aspekard" edbinta, warcelin iyo isticmaalka tirakoob xaqiijin heer sare ah oo ku filan ammaanka at dhaweynta sida uu tilmaamo iyo sababo marka laga reebo. Taas macnaheedu waa in qiyaasta qoray of 100 mg ah ee daawada waa ammaan ah oo ku filan, inkasta oo ay gacanta of xaaladda caafimaad ee loo baahan yahay. Waxaa intaa dheer, in view of askartii oo bukaannada qaba fikirka is dilka, iyo sidoo kale halista in loox oo ASA qaadan doonaa ilmaha, si faahfaahsan loo baahan yahay badinta ixtimaalka iyo astaamaha ay.

salicylates sumowga fudud, xanaajiyeen by codsiga ah ee diyaarinta "Aspekard" aan ah calaamadaha talooyinka dhakhtarkaaga yihiin dalalka soo socda: wareer, xanuun podlozhechkovoy fossa ah, meesha xudunta, mararka qaarkood xanuun, gaar ahaan dadka qaba cudurka kelyaha. Xaaladdan oo ah qiyaasta xad dhaafka ah sida waxaa gariir, matag, mararka qaarkood la xariijimo lagu hoobtay. Ka hore waa via induction ah macmal ah ee emesis: cabitaan qabow badan, habka dhuxusha firfircoonaan iyo bukaanka bixinta ehnterosorbentov isbitaalka.

Muhiimsan, ka qaadasho sun ah "Aspekard" diiwaanka ma sheeg. Waxay kala duwan ee miisaanka iyo da'da bukaanka kala duwan yihiin. Tusaale ahaan, in qof weyn calaamado fudud badinta aadanaha ASA dhacaan hal gelitaanka ku saabsan 5-7 garaam acid. Carruurtu waxay leeyihiin ku filan badinta of 1.5 g dose hal. badinta A badan waxay dhacdaa marka aad codsaneyso 7-9 garaam oo dadka waaweyn iyo caruurta 2-2.5 garaam ASA.

Tani degree of badinta daroogada muujiyey by cudurada kor ku lug leh hawlaha garashada. note badiyay bilaabmaa fikirka tinnitus noqdo wareersan, hadal midaysan. Matag inta badan u dhacdaa, bukaanka si deg deg ah lumiyo dareere ka matag, neefsashada nooleeyaa, waxaa jira haynta kaadida ba'an, korodhay heerkulka jidhka. Caawiyo bukaanka in xaaladda noocan oo kale ah ma suurtowdo in si madax-bannaan - bixinta waxaa looga baahan yahay in NICU ee bicarbonate therapy galiyey, lactate sodium.

Features of action-daweynta "Aspekard"

Lifaaqsan daroogada "Aspekard" hawlgala edbinta kooban ay calaamad u yihiin soo dhoweynta ee hal kaniini maalintii (100 mg / maalintiiba). dose Tani ASA waa ku filan in la xakameeyo cyclooxygenase dhiig xinjirowga. Natiijadu waxay tahay Iscelin of Avv A2 thromboxane, kaas oo gebi ahaanba hakiyo awoodda unugyada in xulkii dhiig xinjirowga. Tani waxay tiraa suurtagalnimada ee thrombosis, taas oo ah sababta infarct infarction ama cerebral.

Si ay u bixiyaan saamayn antithrombotic of acetylsalicylic acid waa in la nuugo galay dhiigga. Si kastaba ha ahaatee, qaar ka mid ah waxaa ka mid ah falalka caloosha iyo sidoo kale anada cyclooxygenase-1 iyo isoforms ay xabka ee xubinta. Natiijada hab this waa saamayn dhinaca - kartida hoos muco-difaaca carbonate jidaar. Tani waxay kordhisaa halista erosions iyo boogaha caloosha, wuxuu kobciyaa iyo mindhicirka-dhiig. daawooyinka Enteric sidoo kale ay awoodaan si ay u abaari dhiig, laakiin inta jeer ee dhinacan saamaynta, ay aad u yar.

Uurka iyo nuujinta

opinion Expert, oo ku salaysan qiimaynta tirakoobka iyo taxane ah oo tijaabo, oggolaanayo in aad leedahay faham cad oo codsiga ah ee "Aspekard" daroogada inta aad uurka leedahay. Gaar ahaan, 1 bilood isticmaalkeeda waa ka mamnuuc. At 2 iyo 3 bilood codsigaaga waa la ogol yahay, laakiin ka dib markii qiimeyn ay isticmaalka daweynta iyo is barbar khataraha soo dhaweynta. In tirada ugu badan ee bukaan eegida ASA xaaladaha ballan loo baahnayn, inkastoo NSAIDs kale sidoo kale ay awoodaan in ay kordhiyaan halista dhicin.

Inta lagu jiro nuujinta, isticmaalaan daroogada "Aspekard" analogues isaga, xabbo, iyo sidoo kale dhammaan daawooyinka la acetylsalicylic acid in sideeda oo waa ka mamnuuc. Sababta tani waa in la garaaco daroogada in caanaha naaska. waxaa guskiisa xataa isaga oo leh ee jidhka ilmaha. Oo ay khatar ku jirto halis sare oo soo koraya Reye ee syndrome - encephalopathy aad u daran, cagaarshowga, kaas oo keena maskaxda oo bararta iyo dhimashada ilmaha. Sababo la mid ah, ka mamnuuc isticmaalka daroogada ka hor da'da 16-18 sano.

Caddaymaha dib xirfadlayaasha iyo bukaanka

Sifeeyay daroogada "Aspekard" warcelin bukaanka xaalado badan u janjeedhaan. Waxay si togan u qiimeeyo qiimaha daawada, tan iyo markii uu soo dhow yahay ugu hooseeya dhex facooda. Si kastaba ha ahaatee, comments la xiriira codsiga la taaban karo oo ka mid ah wax ka yar muujinaysaa awood si ay u qiimeeyaan heerka bukaanka loo yareeyo khatarta thrombosis vascular. In la eego waxyeelo ay soo sheegeen dadka buka, daroogada waxaa lagu gartaa sida ku filan ammaan ah.

Opinions khubaro ah waa cad yahay: marka hore, daroogada waa ku ool yaraynta khatarta thrombosis, iyo marka labaad, bukaanka addeecitaanka antiplatelet therapy sareeyo sababta oo ah hooseeyo "Aspekard" qiimaha daroogada. Analogs ee fasalka ka mid ah wakiilada antiplatelet ay si weyn uga sare. diyaarinta Domestic enteric "Atsekardol" qaalisan by 50%, halka qiimaha keeno sare by 7-10 jeer. Laakiin oo ku salaysan yar waxyeelo wakiilada enteric, iyo sidoo kale natiijada dhaqaale, waa la jecel yahay in ay mudnaanta siiyaan in ay "Atsekardolu". Qiimaha daaweynta bil kasta noqon doonaa oo ku saabsan 20 rubles.

La'aanta Ujeedada of kardiopreparata "Aspekard"

Lifaaqsan daroogada "Aspekard 100" diiwaanka sheegay in daroogada waxaa laga heli karaa kiniin. Waxay baabbi'isaa caloosha iyo soo saaro tirada badan. Bixinta saamayn gastrotoksichesky maxaliga ah, daroogada lumiyo daroogada Safety kale, kuwaas oo enteric. khatarta dhiig-gastric markaad codsanayso dambe waa wax badan ka yar.

Tusaale ahaan daawooyinka ammaan waa sida soo socota: ". Aspirin wadnaha" "Atsekardol", "Polokard", "Cardiomagnyl", Waxaa intaa dheer, ayaa sheegay in hab sidoo kale ka kooban hydroxide magnesium, awood si ay u ilaaliyaan xabka dhaawac by acetylsalicylic acid. Si kastaba ha ahaatee, daroogada "Aspekard" ayaa loo isticmaali karaa ka hortagga formation thrombus, inkastoo xayiraad. Si kastaba ha ahaatee, bukaanka isagoo nabaad xuubka, boog 12 malawadka ama caloosha, oo ay ku jiraan chronic ah, waxaa lagu talinayaa in ay qaataan kardioformy enteric acetylsalicylic acid.

Vneotraslevoe codsiga kardiopreparata "Aspekard"

Inta badan oo ka mid ah tilmaamaha la heli karo si loogu isticmaalo muujinaysa joogitaanka antiinflammatory iyo guryaha qandhada daroogada "Aspekard 100". Dhab ahaantii, daawo buuxda uu raad-daweynta waa 5 jeer qiyaasta hal - 500 mg. qiyaasta of 100 mg waa gaar wadnaha, iyo saamaynteeda ahi kuma filla in ay si waxtar leh loo yareeyo heerkulka ee cudurada faafa.

Kardioforma diyaarinta macmalay in qiyaas 100 mg, waa ku haboon yahay xanuunka iyo gargaarka qandho kaliya la dose of 5 hal kiniin. Sayidka selectivity ku badan yihiin waayo cyclooxygenase 1 go'aamiso joogitaanka hannaanka ah reactions dhinaca. Sidaa darteed, sida febrifuge a kiniinka "Aspekard", dabcan, ku haboon yihiin. Si kastaba ha ahaatee, xilligan waxaa jira tiro ka mid ah tiro ka mid ah daroogada ammaan bandhigista selectivity weyn cyclooxygenase 2. Waxay sidoo kale ku waxyeellooyin yar oo la xidhiidha xad-gudub ku ah kororka of epithelium caloosha iyo mindhicirka.

dhigooda fasalka Safety "Aspekard" daroogada

Baaxaa A la mid ah ayaa lagu arkay daawaynta cudurada rheumatic. Oo ku lifaaqan daroogada "Aspekard" edbinta si loogu isticmaalo waxaa ku qoran warar ku saabsan daaweynta. Si kastaba ha ahaatee, qiyaasta lagu taliyey in amarka of 5-8 g maalintii.

Tani qadarka acetylsalicylic acid muujinaysaa gastrotoxicity incomparably xoog saamayn badan markii Daawooyinka "meloxicam", "celecoxib", "Roferoksib" iyo kuwa kale. Oo sida qandhada analoogga fasalka ugu qiimaha badan waa "Ibuprofen".