TSH Hormone: muhiimadda nafsaaniga ah

TSH hormone The (hormone thyroid-madadaalo, thyroid-stimulating hormone) wuxuu kobciyaa horumarka iyo waxqabadka qanjirka thyroid ka. walax waxaa marka hore go'doonsan wax laga soo Soocay pituitary ee. TSH waa glycoprotein leh miisaan kelli ah ka 23,000 in 32,000 daltons waa diyaar L. biyo, wax aan nooleyn by pepsin, trypsin iyo chymotrypsin. hormone TSH ka kooban yahay α- iyo β-subunits. α-subunit uu leeyahay qaab-dhismeedka la mid ah ma aha oo kaliya hormone kala duwan (lutropin iyo thyrotropin) iyo hormoonada iyo noocyada xoolaha kala duwan. Waxay ku kala duwan ka soo kasta oo kale oo kaliya in qaab-dhismeedka moieties carbohydrate ah. The dhaqdhaqaaqa noolaha gaar ah ay go'aamiyeen sifooyinka ku hormone β-subunit. Si kastaba ha ahaatee, hawshan waxaa ka go'an oo kaliya ka dib markii qabanaya of α- iyo β-subunits.

Iyada oo la kordhiyo hoos mabda'a uruureen dhiigga thyroid hormoonnada Avv thyrotropin -celin xun: Avv tireolibirina hypothalamus hoos ku hypophysis ah - melanotropin, thyroid - tyroksiini.

TSH hormone The kobciyaa koritaanka iyo horumarka kiishashka thyroid epithelial iyo shidaa waxqabad ee organelles in ay ku lug biosynthesis ee hormoonnada ay. farsamo ee ay tallaabo ka kooban yahay dhowr marxaladood: marka hore, TSH hormoonka shidaa formation xerada, waa, markeeda, biosynthesis thyroglobulin. Thyrotropin kor "qabsadaan" unugyada follicle iodine iyo qaybsama galay hormoonnada thyroglobulin shaqsi iyo intii ka hadhay borotiinka.

hormone The kobciyaa nuugo ogsijiin by unugyada qanjirka thyroid iyo Kordhiyey permeability in monosaccharides, acids amino iyo xarumaha kale ee noolaha.

In cuduro of TSH pituitary jilibka hoos Avv oo markii danbe u keenaysaa in Iscelin of biosynthesis ee hormoonnada thyroid,. Tani waxay keeni kara horumarinta cudurada sida goiter iyo myxedema.

Morphological iyo functional qaybo ka mid ah thyroid qanjirka tahay epithelial unugyada iyo kiishashka, oo waxaa ka buuxa ah viscous huruud ah dareere - Colloid. Halabuurka The lagmamaarmaanna u ah ee ay wakiil inta badan protein - thyroglobulin. Waxaa iska leh glycoprotein leh kelli miisaanka of 660.000 Daltons. Waxaa ka mid ah thyronine, taasoo ka timi uumiga laba taagoo tyrosine (amino acid). Thyronine waa wax ugu weyn ee dhismaha hormoonnada thyroid iodinated - tyroksiini (tetraiodothyronine T4) iyo triiodothyronine (T3), kuwaas oo ku dhexsameeysmo qanjirka kiishashka.

In dhiigga hormoonada kuwaas oo ku xidhaan in borotiinada plasma iyo wareegaya ee jirka. Marka xiriir la unugyada bartilmaameedka dumin brotiin iyo hoormoonka loo qoondeeyey in dheecaanka intercellular. Inta badan hormoonnada ku jira gacanta waxaa ku urursan hyaloplasm, yar - ee mitochondria iyo ribosomes.

hormone TSH Low dhiigga shaqeeyo dhallinyaro ah waxay keeni kartaa cretinism, iyo dheellitirnaanta jidhka oo liita. In dadka waaweyn - waxaa weeye myxedema. Tani waxay abuurtaa bararka, biyo la hadhay ee nudaha ku hoos-shiid asalka, tabar guud dhacdaa, cayilka silica iyo gaboobijiyaa. Haddii hypothyroidism dhacdaa marka la'aanta iodine ee cuntada iyo biyaha, horumarinta gud goiter, ka qanjirka thyroid kordhay size.

Marka hyperfunction thyroid dhacaa cudurka Graves ' (goiter waajihi sun ah). Sababaha waxaa laga yaabaa kala duwan: sarkhaan chronic, cudurrada faafa, iwm Under saameynta ay hormoonnada kordhiyaa permeability ee xuubka unug, gaar ahaan mitochondria ah. Xaaladdan oo kale, xadgudbay cayn kasta oo shiid, horumarisa intoksikoz.

Mararka ay dhacdo TSH hormone waa Qolol, daaweynta waa in la fuliyaa waqtiga. In daaweynta cudurada this qoray therapy hormoon la isticmaalayo diyaarinta iodine.