Daawada "Ursodez" - tilmaamaha loo isticmaalo. Kiniiniga "Ursodez": analogs iyo dib u eegis

Drug "Ursodez" - daroogada hepatoprotective. Waxay leedahay medicament choleretic, hypolipidemic, tallaabo holeliticheskoe, uu leeyahay hypocholesterolemic iyo immunomodulating saamayn dayac badan. walax firfircoon - ursodeoxycholic acid. daroogada waxay leedahay qaab qiyaasta lahayn "kiniinka". "Ursodez" waxaa la soo saaray qaab kaabsulka.

hab waxqabad

The walax daroogada firfircoon uu awood u leeyahay in lagu daro xuub ee hepatocytes, xasilinta dhismeedkooda. Sidaas darteed, unugyada laga badbaadiyo arrimo aan fiicnayn, waxqabadka ee cusbada bile acid. Saamaynta daweynta of daroogada muujiyey sidaas hoos saamayn cytotoxic ah. Against asalka ah cholestasis shidaa Ca2 + protease tiirsan exocytosis Alfa-shidan yihiin. Oo macnaheedu yahay "Ursodez" (Codsiga User waxay muujinaysaa) si weyn u yaraynaysaa acids bile sun (deoxycholic, lithocholic, chenodeoxycholic iyo kuwa kale) ee ay isugu soo urureen kacsantahay in bukaanka qaba heley cagaarshowga koorsada chronic.

Marka aad hesho daawo calaamadeeyay hoos u dhac ku Avv kolestarool ah iyo dheecaan, Iscelin of ay nuugista ee xiidmaha. Sababo la this, waxaa hoos u damaysay ee bile leh xarunta this. diyaarinta wuxuu leeyahay awood u leh inay tartan hoos absorbability ee acids lipophilic ku jira xiidmaha, kordhinta ay jajab ciidda isbeddelkaas wareegga enterohepatic. Daawada wuxuu kobciyaa Digo ee acids sun ah, marinka kordhay.

hab ay of tallaabo daroogada ayaa waxaa sidoo kale ku salaysan baarista acids bile nonpolar. Taas darteed micelles isku qasan sun. Waxaa loola jeedaa sii xoogeysanayo nidaamka biliary, milmi ee kolestaroolka, xasilin-soo-saarka iyo dheecaan of bile. daroogada ayaa sidoo kale waxay yareysaa ay lithogenicity, waxay kordhisaa-fiirsashada ee acids, sidaas xanaajin la kordhiyo waxqabadka of dheecaan ganaca iyo gastric.

Marka la helo kaabsulka ku lahaa kala diridda dhammaystiran ama qayb ka mid ah dhagaxyo. By yareynta kolesteroolka bile robab wanaajiyey abaabulka ay dhagaxyadaas. dhaqdhaqaaqa Immunomodulatory waxaa soo bandhigay ay sabab u tahay saameynta ay ku dareen kala by beerka. Daawada yaraynaysaa muujinta tiro ka mid ah cudur histocompatibility. medicament waxa uu leeyahay saamayn ku yeelan heerka T-limfosaytis, hoos u dhigtay tirada of eosinophils.

hab Pharmacokinetics

Nuugista daawada "Ursodez" (diiwaanka muujinaysaa this) ee xiidmaha yar sameeya habka ah sida- dadban. Bixiyay leh oo ku saabsan 90% ka mid ah qayb firfircoon. In axalaha walaxda la nuugo gaadiid firfircoon. content ugu sareeya ee ka kooban firfircoon gaadho qiyaastii hal saac. Xarunta waxay leedahay boqolkiiba sare ah protein ku qabanaya - 99%. Ursodeoxycholic acid waa ay awoodaan in ay dhex gasho mandheerta.

oggolyahay ayaa ku daweyn of daroogada waxay ku xiran tahay midda of qayb firfircoon bile ah. At aqbaliddoodii nidaamsan oo joogto ah tan acid bile noqdo serum aasaasiga ah. fiirsashada acid ursodeoxycholic wuxuu ku saabsan yahay 48%.

Xarunta waxaa metabolized, waxaa maraa unugyada beerka. Sidaas darteed, la aasaasay glycine iyo taurine conjugates. alaabta suuska waxaa ku qarisay galay bile. About 50-70% helay daroogada waxaa raaca saxarada ka. Qaddar yar oo daroogada la qaado galay xiidanka. Waxaa u kala qaybsan by tallaabada ee bakteeriyada (7-dehydroxylation).

Lithocholic acid, taas oo la aasaasay by habkan, waxaa lagu sakhiray in nuugista a qayb ka mid ah xiidmaha waaweyn, laakiin maraa sulfation beerka iyo raaca sida sulfolitoholiltaurinovogo ama conjugate sulfolitoholilglitsinovogo.

maragga

Daawo "Ursodez" talinayaa sida daaweynta ah calaamadaha hoose cirrhosis biliary oo aan calaamado decompensation. Tusaya adeegsanayo si ay u milmaan dhexe iyo dhagaxyo kolestaroolka yar, iyada oo kaadi firfircoon. Qorayaasha la gastritis reflux biliary.

sababo

Ka dhigan tahay "Ursodez" edbinta ku saabsan codsiga aan u oggolayn in ay caga haddii qaybaha medicament soosaaray rentgenpolozhitelnyh bukaan socodka (ka-fiirsashada sare ee Ca2 +) dulqaad. Sababo ka mid ah cirrhosis in decompensation tallaabo ka muujiyay xanuunada ah xameetida, kalyaha. daroogada lagula talinayaa dadka la non-shaqeeya xameetida, heley ba'an bararka oo ay dabiicadda, iyo sidoo kale cudur malawad oo koollo bile. Ha qoro dawooyinka si ay uurka leh iyo xanaanada. Macnaheedu ahaan uu dadka waaweyn iyo caruurta oo miisaankeedu yahay in ka yar 34 kg.

waxyeellooyin

Xaaladaha qaarkood, horumarinta saamaynta rabin halka qaadashada daroogada, "Ursodez". Tilmaamaha loogu isticmaalo Digo suurtagalnimada ee lallabo, shuban, matag. In daaweynta ciidda sameysmi karaa soosaaray calcified. Weyneeye hawl transaminase beerka, calool xanuun, dareen diidmo oo xasaasiyadeed (oo ay ku jiraan urtikaria) ayaa sidoo kale loo baahnayn qofku cuno cawaaqib "Ursodez".

Kurtumm tusi tolerability wanaagsan. Subject in waxyeelo daawada dhakhtarka uma badna. Mararka qaar, inta lagu guda jiro daaweynta cirrhosis biliary arkay decompensation transient. Sida caadiga ah, this ifafaale oo keliya sii socoto ka dib markii uu joojiyo of daroogada.

Drug "Ursodez". Price. barashada

Macneheedu yahay in aad fiidkii. qiyaasta maalin kasta dhagaxyo kala diridda - celcelis ahaan 10 mg / kg. Waayo, dadka kor ah oo miisaankeedu yahay 60 kg u dhiganta kaabsoosha 2aad maalin kasta in 81 kg- 3-m, 100 kg - 4 ka badan 100 - 5. Duration - lix bilood ilaa 12 bilood. Ka dib kala diridda dhagaxyada si looga hortago formation of qaadashada cusub talinayo dhowr bilood oo kale.

Daaweynta cirrhosis biliary fuliyay at dose oo ah 250 mg / maalintiiba. Duration koorsada - 10-14 maalmood. ilaa lix bilood. Xaaladaha qaarkood, muddada daawaynta waxaa kordhay laba sano. Sida daaweyn astaamaha medicament maamula 10-15 mg / maalintiiba. Marka mass in ay 34 kg talinayo hab qaab ganaax. Qiimaha daroogada ee foomka kaabsal - mid ka mid boqol rubles.

Waxa ay ka dhigan tahay dhigooda "Ursodez"?

Daawooyinka ay ku jirto walax isku mid ah oo firfircoon, soo saaray wax badan oo ilaa xad ah. iyaga ka mid ah waxaa xusid mudan hab sida "Ursodoksa", "Ursol". Mid ka mid ah kuwa ugu caansan waa daroogada "Ursosan". Tilmaamayaasha ay u isticmaalaan daroogada waa xoogaa sii ballaadhan. Gaar ahaan, waxaa la maamulo ee fibrosis beerka fibrosis cholangitis skleroziluyuschem nooca chronic.

Bukaan badan ayaa xiiso u diyaarinta waxa wanaagsan "Ursodez" ama "Ursosan". Waa in la sheegay in dhakhtar ay doorteen mid ka mid ah ama siyaabo kale oo waafaqsan nooca, dabcan ka mid ah cudurada iyo bukaanka dulqaadan daroogada. In cudurrada beerka oo, kaadi haysta waa heer sare ah lagu talinayaa in aan is. Ka hor inta aysan wax daawo ah aad u baahan tahay baaritaan iyo la tashi la takhasus u leh.

Kormeerka hirgelinta daaweynta waa in la sameeyaa 6 bilood kasta. In xiriir this waxaa loo xilsaaray ultrasound si joogto ah iyo baaritaan X-ray in sannadka ugu horeeya ee daaweynta. Haddii in lixdii bilood ee ugu horeysay kala diridda ay dhagaxyadaas laga ma dhicin, waa sii badan tahay dabcan ka shaqayn karto sabab u ah karti.

macluumaad dheeraad ah

Si loo hubiyo kala diridooda ku guul oo dhagaxyo ah waxaa lagama maarmaan ah in dhagaxyo waxay ahaayeen kolestaroolka oo kaliya, laakiin ma ay size in aanay ka badan 15 ama 20 milimitir. Isla mar ahaantaana la xameetida ka buuxsantay Waa in aysan jirin ka badan kala badh, iyo mareenka biliary waa in xajisto ay shaqo gabi ahaanba.

In the case of caga sii dheerayn daaweynta, in ka badan muddo bil ah, waxaa lagama maarmaan ah si ay u fuliyaan dayo a lagmamaarmaanna u ah ee qiimaynta waxqabadka ee transaminases beerka. Intaas waxaa sii dheer, waa in la xakameeyo fiirsashada of bilirubin iyo xarumaha kale. joojisid qaadashada macnihiisu yahay "Ursodez" iyadoo la sii waxqabadka sare. Reviews khubaro badan, si kastaba ha ahaatee, waa wanaagsan oo ku saabsan waxtarka daawada.

gunaanad

Haddii natiijada ma ahaan loogu talo galay medicament kale ama istiraatiijiyad daaweynta gebi ahaanba dib loo eegay. Ka hor inta isticmaalka sheyga waa in aqoon annotation ah.