Antibiotic "Linezolid": tilmaamaha loo isticmaalo, dhigooda qiimaha, foomka sii deynta iyo dib u eegis

Inta badan dawada loo yaqaan ee cudurrada bakteeriyada ama fayras kasteba daaweynta by daroogada caadiga ah. Si kastaba ha ahaatee, waxaa jira wareer in ay ku habboon shuruudaha loogu yeero nosocomial. Dagaalka iyaga ka gees ah waa shaqo aad u adag, maxaa yeelay, dawooyin badan oo ay si fudud uma shaqeeyaan. Antibiotic "linezolid" waxa loola jeedaa daroogada kuwa kaas oo wax laga qaban karo loogu yeero cudurada nosocomial ama wax kale oo adkaysi u noocyada kale ee daroogada. Taasi waxa ay ku saabsan iyo laga wada hadli doonaa in this article.

description

Drug tilmaamaha "Linezolid" khuseeyaan antimicrobial ballaadhan-spectrum. Sida laga soo xigtay guryaha iyo astaamaha asaasiga ah ay u sugnaaday in oxazolidinone fasalka in xoog iyo kala duwan oo ka mid ah tallaabo sheyga siyaabo badan ka sareyso daroogada "Vancomycin" iyo alaabooyinka kale ee la Halabuurka la mid ah.

Maanta, waxaa jira dhowr nooc oo ah wakiilka antimicrobial "linezolid". foomka Product, waxaa inta badan la isticmaalo ee therapy, - a kiniiniyada qolof xuub ka kooban 400 ama 600 mg oo ah walaxda firfircoon. Intaa waxaa dheer, in dhaqanka caafimaad xal galiyey waxaa badanaa loo isticmaalaa, taasoo mililitir kasta waxaa ku jira 2 mg oo ah walaxda firfircoon iyo budada (dhagaxyada ah) si ay u diyaariyaan ganaax ah, fiirsashada of qayb firfircoon taas oo 100 mg halkii 5 ml oo ah wax soo saarka final.

Tilmaamayaasha

Sida hore u soo sheegnay in this article, buuga daroogada "Linezolid" edbinta ku talinaysaa in aad isticmaasho joogitaanka caabuqa ay keento bakteeriyada adkaysi u antibiotics kale. Waxaa ka mid ah sheyga labada garaam-positive iyo garaam-negative ka tirsan anaerobic ama nooc laylinta in in ay adkeysimo (xasiloonida) si Methicillin, xeryahooda gikopeptidnym, penicillin iyo antibiotics kale.

Liiska cudurada taas oo ah "linezolid" edbinta medicament ka mid ah:

• isbitaalka ama pneumonia bulshada heleen;
• cudurada maqaarka,
• cudurada unugyada jilicsan,
• cudurada kale ee ay keento antibiotic u adkaysta Enterococcus.

Sida caadiga ah, ka hor inta la isticmaalayo cilmi daroogada sameeyay this si ay u aqoonsadaan iska caabin ah ee wareer ah in daroogooyinka kale. Haddii midkoodna la helay, daaweynta waxaa lagu fuliyaa iyadoo la kaashanayo daawooyin kale antimicrobial.

sababo

contraindication ugu weyn oo ugu muhiimsan ee la isticmaalo oo ka mid ah antibiotic 'Linezolid' tilmaamaha loo isticmaalo waxaa loola jeedaa diidmo, waxa uu. Waxaa sidoo kale aan lagu talinayaa in la isticmaalo daroogada si loogu daweeyo bukaannada kuwa qaadato daawooyin kale ka tirsan ee MAO. Intaa waxaa dheer, waxaa laguma talinayo wakiilka this wada jir ah ula murugada tricyclic iyo walxaha awood si kor loogu qaado cadaadiska dhiigga (epinephrine, dopamine, iyo triptan kale).

Diyaarinta "linezolid" (kiniin, xal faleebo iyo slurry ah) waa u ee cudurada sida hypertension, tayroodh, ama seratoninovy syndrome carcinoid, feohromotsitoz. Joogitaanka sababo waa la ogaan ka hor bilowga therapy isticmaalayo daroogada.

Hab of tallaabo daroogada ee jirka

Action "Linezolid" daroogada ay sabab u tahay kartida si loo joojiyo nidaamka turjumaad dhismayaasha protein ah ee unugyada bakteeriyada. Sababo la xiriira kororka of sheyga la joojiyo oo halkaas waa dhimasho. Resistance si daroogada ee inta badan ee bakteeriyada la soo saaray si tartiib ah.

Ka dib markii uu qofku cuno ee qayb daroogada firfircoon foomamka glycine hydroxyethyl metabolite ah. Degree ee ay ururka la borotiinada plasma gaaro qaab ciyaareed 31%. In shaybaarka waxbarashada ogaaday in xarunta guskiisa galay dhammaan unugyada iyo xubnaha. Waxa kale oo uu awood u leeyahay inay dhex maraan mandheerta caanaha ilmaha caloosha iyo naasaha (aan dhaxlayn this daroogada ka muuqataa talooyinka qaadashada daroogada by haweenka uurka leh iyo kuwa nuujinaya).

The bar-nolosha oo ah walaxda firfircoon oo ay metabolite raaca waa 4.5-5 saacadood. Digo waa via habka kaadida (50% sida metabolite ah iyo 35% dhawrsan), iyo iyada oo marinka dheef shiidka (aan ka yarayn 9%). Buuxi Digo dhacdaa 8-12 saacadood gudahood ka dib marka la helo medicament.

Sida loo qaato "Linezolid"

Khubarada tilmaamay in kiisaska intooda badan bukaanka madax banaan oo aan ka dhigi kara go'aan ku saabsan habka ay u soo dhoweynta "Linezolid" daroogada. Fiiro gaar ah, kiniin, xal iyo emulsions oo aan waxaa loo tixgeliyaa sida diyaarinta gaar ah, oo sida nooc ka mid ah daroogada, oo ay ku jiraan markan faahfaahin buuxda. Hoos waxaa ku qoran qodobada muhiimka ah ee ku saabsan qiyaasta iyo muddada daawaynta.

Daawo "Linezolid" diiwaanka soo jeedinaya isticmaalaya qorsheyaasha soo socda:

1. Xalka for galiyey waxaa maamula intravenously 2 jeer maalintii. Hal dose oo ah 400-600 mg walax firfircoon. Muddada aad daawada ku xiran tahay darnaanta cudurka iyo ay deegaamaynta. Caadi ahaan, cudurada ugu baahan yahay in muddo ah ugu yaraan 10 iyo wax ka badan 14 maalmood, oo kaliya in cudurada ay keento enterococci, daaweynta socdaa 2 ilaa 4 todobaad.
2. Diyaarinta "linezolid" (kiniin) loo qaato sida 2 jeer maalintii qadarkuu of 400 ama 600 mg soo dhaweynta. Bukaanka jirta 5 ilaa 14 sano, qiyaasta loo xisaabiyaa ku salaysan miisaanka jidhka oo ahaa 10 mg halkii 1 kg ee miisaanka jidhka, 2 jeer maalintii. Qiyaasta ugu badan halkii qofku cuno (p.o.) waa in aanay ka badan 600 mg. Muddada daaweynta waxaa lagu go'aamiyaa oo xuduudaheedu isla kaas oo la kor loo arkaa.
3. Dhagaxyada ah, kaas oo waxaa la sameeyey ee emulsion ah, codsatay by nidaamka kor ku xusan. Xisaabinta qiyaasta marka waxaa lagama maarmaan ah si ay u fuliyaan sida ay hagaya oo isku mid.

Tan iyo daroogada "Linezolid" waxaa si gaar ah loo qoondeeyey by qoro oo loo isticmaalo oo kaliya in isbitaalka, badinta ee xarunta iyo muuqaalka kore ee waxyeellooyin fahmayaan waxaa gebi ahaanba ka reebtay. Dhakhaatiirta in dib u eegista ay ku xusan xaaladood oo raasamaal xad-dhaaf ah ee jirka ku jira oo ah walaxda maandooriyaha firfircoon oo metabolites ay sabab u tahay cudurada oo ka mid ah xubnaha kaadida iyo beerka. Cawaaqibka xad dhaafka ah sida waxaa sida caadiga ah si dhakhso ah saaray, sida bukaanka loo daaweeyaa iyada oo ay kormeerayaan joogto ah oo khaas ah.

isdhexgalka daroogada

Tan iyo markii mid ka mid ah foomamka qiyaasta of daroogada "linezolid" waxaa loogu talagalay ee maamulka xididka, waxaa muhiim ah in daawadu ay gebi ahaanba la jaan qaada ee xal aasaasiga ah loo isticmaalo inta lagu jiro daaweynta (5% xal glucose, xal 0.9% of chloride sodium iyo xal Ringer ee).

fiiro gaar ah in la bixiyo, in xaaladda bukaanka, kuwaas oo lagu daro "Linezolid" qaadato daawooyinka adrenergic. Haddii diidmo buuxda oo dambaysta ah suurtogal ma aha, takhaatiirta u baahan tahay inay dib u eegaan oo ay qiyaasta.

Daawo "Linezolid '(oo la mid ah in Halabuurka sidoo kale la dhigantaa karo) si buuxda u socon kara daawooyinka" chlorpromazine "," cotrimoxazole "" Diazepam "iyo" phenytoin ". Haddii bukaanka ka hor codsiga ah antibiotic ka qaatay ayaa sheegay in hab loo baahan yahay in la joogteeyo bareeg 3 maalmood ka hor daaweynta "linezolid" diyaarinta.

ganaaxyada

Sida talooyin dheeraad ah oo ku saabsan isticmaalka antibiotics "Linezolid" diiwaanka ku jira macluumaad la xiriira haweenka uurka leh iyo dadka qaba comorbidities jira. Intaa waxaa dheer, waxa tilmaamay in suurtagalnimada waxyeellooyinka. Laakiin wax ugu horeysay ugu horeysay.

Sida dhaweynta "Linezolid" dib u eegista daroogada ee dhakhaatiirta hadalka ku saabsan digniin gaar ah marka ay maamusho in haweenka uurka leh iyo kuwa nuujinaya. Tan waxa u sabab xaqiiqada ah in saamaynta daroogada on caloosha ku dhaco ama ilmaha dhashay ayaa si waafi bartay. Guud ahaan, daaweynta waa la isticmaalo waxaa lagu talinayaa oo keliya haddii khatarta in ilmaha caloosha ku si weyn hoos lacagta la filayo in hooyada.

A kelyaha iyo adag failure cagaarshowga, ayaa sidoo kale u baahan yihiin codsi taxaddar of daroogada, maxaa yeelay, metabolites waxaa raaca inta badan ee xubnaha kuwan, oo raasamaal oo ka mid ah walxaha iyaga oo ku keeni kartaa sii daraysa ee bukaanka.

waxyeellooyin

Iyada oo ku saleysan natiijooyinka indhaynta clinical, dareen diidmo oo aan loo baahnayn oo ka mid ah xubnaha kala duwan iyo hababka ugu antibiotic soo dhaweynta "linezolid" ee badanaa ku dhaca nidaamka neerfaha iyo dheefshiidka. About 10% bukaanka lagu jiro daaweynta lagu arkay lallabo iyo madax xanuun. Wax yar ka yar ka walwalsan shuban ay, dawakhaad, iyo candidiasis in xuubka afka.

Intaa waxaa dheer, khubarada tilmaamay saameynta aan la rabin sida daroogada sida neuropathy durugsan, suuxdin, iyo aragga (ilaa ay wadarta khasaaraha), Torombositobiiniya, serotonin syndrome, anjioedema iyo shoog. Sababo la xaqiiqada ah in daawada waxaa loo isticmaalaa oo kaliya in jawi isbitaalka, cawaaqib inta badan halis ah waxaa laga fogaanayaa.

Daaweynta muuqday dareen diidmo oo aan loo baahnayn on qayb ka mid ah astaamaha iyo nidaamka. Removal of daroogada ayaa suuragal ah keliya haddii darnaanta waxyeellooyin waa dhibaato wayn ka badan cudurka lagu daweynayaa tixgeliyo antibiotic.

analogues Drug "Linezolid"

Readers malaha qabto su'aal ku saabsan in analogues "Linezolid" daroogada waxaa. Dabcan, suuqa dawooyinka, haddii aan ka buuxa, waxa ay leedahay a daroogada yar oo la mid ah, kuwaas oo ka kooban antimicrobial. Daawooyinkan waxaa la xidhiidho antibiotic "Zeniks" "zyvox" Norwegian Serbia iyo Israel "Linezolid Teva". Halabuurka The oo dhan daawooyinkaan sida hubaasha weyn ee firfircoon ka mid linezolid.

Ma jiraa faraq weyn oo u dhexeeya habka iyo diyaarinta "Linezolid" kor ku xusan? Qiimaha daroogada - in farqiga ugu weyn. Xaqiiqdu waxay tahay in isagoo Halabuurka la mid ah, daawooyinkan u dhaqmaan on jidhka bini'aadamka in si sax ah isku mid: dhibtoonayo ah sheyga la mid ah, waxay keeni saamaynta xun isku mid ah ay yihiin sababo la mid ah. Aan wax badan laga eego iyo hababka daaweynta iyo qiyaasta kala duwan.

Sida caadiga ah, analogues keeno "Linezolid" antibiotic ka qaalisan loo isticmaalo in ay dhacdo in this daroogada gaar ah ma aha joogo in iska-. Tani waxay badanaa ka dhacdaa, sababta oo ah isticmaalka tiro balaadhan oo ah bukaan waa ku dhowaad aan macquul aheyn sababo la xiriira dawooyinka iyo badin on khaanadaha aan lagu xallin karin mid ka mid ahaa silsilad farmashiyaha. Laga soo bilaabo tan yar daroogada jaale xisbiga iyo, Sidaa darteed, fursad barta qaar ka mid ah inay iska iibiso stock oo dhan.

Qiimaha daroogada

The medicaments koox oxazolidinone leeyihiin qiime sare sabab u ereygu wuxuu adag multistep oo ah walaxda in laboratories dawooyinka. Waa maxay "Linezolid" qiimaha daroogada? Kiniiniga (content ee ugu weyn walax firfircoon 600 mg, pack of 10 xabbadood) silsilado farmashiyaha waa ugu yaraan 18 kun. Qiimaha ugu badan ee foomka qiyaasta tani waa 20 kun oo rubles 10 kiniin. Wax yar ka jaban yahay daroogada at dose oo ah 400 mg. Its qiimaha ku saabsan tahay 17-18 kun oo rubles 10 kiniin.

Xalka for galiyey "Linezolid" aad ka iibsan kartaa wax yar oo jaban: pack of 10 xirmooyin ee 100 ml ku kici doona 7.5-9 kun rubles, 10 baakad kasta 300 ml - in 15,3-16,2 kun rubles.

The diyaarinta of magac la mid ah, kuwaas oo wax badan ka jaban, inta badan soo baxayso in been ah iyo, at ugu fiican, waxay leeyihiin saameyn ah kuma laha jirka bukaanka. Si kastaba ha ahaatee, dib u dhac ah ee daaweynta cudurka, taas oo ka caawisaa laga takhaluso oo ka mid ah 'Linezolid' antibiotic laftiisa waa mid aad u halis ah. Taasi waa sababta khubaro ku talinaynaa in la helo daawada kaliya ee farmashiyaha la sumcad wanaagsan.

Comments saabsan antibiotic "Linezolid"

ilo kala duwan ayaa dhif ka heli kartaa dib u eegista ku saabsan antibiotic of class this. Tani waxay si gaar ah u khusaysaa macluumaad ku saabsan gelitaanka, bukaanka ku tilmaamay. Tan waxa u sabab xaqiiqda ah in inta badan bukaanka lagu jiro daaweynta ku jira xaalad aad u daran, iyo xusuusan weeraryahan sidato oo dhan iyaga oo dareensan yahay mid aad u adag.

Khubaro, markeeda, jawaabaan daawo "Linezolid" mid aad u wanaagsan. Sida laga soo xigtay iyaga, daroogada waa inay awoodaan inay la qabsadaan xataa jeermiska ugu adkaysi. Waxay sidoo kale tilmaamay in halista jahawareerka ay sabab u tahay waxyeelo ama xad dhaafka waa shiidaa jiritaan la'aanta. Tan waxa u sabab xaqiiqada ah in antibiotic ah waxaa loo isticmaalaa oo kaliya in goobaha isbitaalka. At calaamadaha ugu horreeya ee cadaanyo ama loo kasin in daroogada ayaa lagu fuliyaa oo dhan nidaamka caafimaadka lagama maarmaanka u ah iyaga la baabi'iyo.

Sidaas daraaddeed, waxaan eegay oo dhan faahfaahinta daroogada "linezolid" ah. Tilmaamaha loogu isticmaalo, qiimaha iyo jawaab suurto gal daroogada ayaa tilmaamay in warqad this si faahfaahsan. Waa in la ogaadaa in, inkastoo qiimaha sare ee daroogada, isticmaalkeeda waa xaq in kiis kasta. Si aad u go'aansato on daaweynta bukaannada daroogada this kartaan dhakhtar oo kaliya.