ALT kordhay. Maxaa la sameeyaa?

alanine aminotransferase (ALT) enzyme ku jira beerka loo isticmaalaa sida tilmaame in lagu ogaado cudurada of hawlihiisa. Waa maxay macnaha xaqiiqada ah, haddii heerka ALT kordhay?

Ka mid ah ensaymes badan oo tilmaamayaasha xanuunada hepatocellular, ugu waxtar leh oo lagama maarmaan ah alanine aminotransferase (ALT) iyo aspartate (AST). iyaga degdegsiimada falcelin kala iibsiga ee gamma-gamma aminotransferase ketoglutarate guuto iyo kooxaha aspartate. Sida ka dhashay geedi socodka waxa ay soo saartay pyruvic iyo oxaloacetic acid.

Oo ALT iyo AST - gacanta ensaymes kelyaha, beerka, wadnaha. Si kastaba ha ahaatee, alanine aminotransferase, inta badan ku yaala beerka iyo waa ugu aasaasiga ah ee ay tilmaame, iyo alanine aspartate -. Iyada oo qayb ka mid ah dad badan oo (kale oo aan ahayn kuwa kor ku xusan) ee xubnaha iyo unugyada, oo ay ku jirto murqaha lafaha, maskaxda, iwm Tani waa sababta AST muhiimka enzyme waa ku yar yahay sida tilmaame of beerka, iyo waxa ay ka qayb-shiid amino acid qaadataa.

Haddii uu jiro burbur unugyada beerka, wadnaha, kelyaha, alanine aminotransferase (ALT) ee dhicistu dhiigga. Kordhi of eulayska gacanta ku Halabuurka dhiigga muujinaysaa cudurada qarsoon. Marka baadhistu waxay muujineysaa in heerarka ALT sare, waxaa laga yaabaa in la horumariyo cudurada arrin khatar ah in dhiigga, sida:

- cirrhosis,

- hepatitis viral,

- myocarditis,

- kansarka beerka,

- wadnaha oo shaqadiisa gaba,

- wadno.

Oo alanine aspartate korodhka dhiigga waxay keeni kartaa in

- wadno,

- kansarka beerka,

- Dystrophy muruqa ah ,

- ganaca,

- myoglobinuria paroxysmal,

- hepatitis,

- dermatomyositis,

- wadnaha oo shaqadiisa gaba.

Haddii, si kastaba ha ahaatee, heerka guud ee AST oo ALT kordhay, waxaa laga yaabaa:

- galleeyda cagaarshowga ballaaran,

- dhaawac beerka toksinogennye,

- hepatitis viral daran,

- muddo-vascular burburkii.

Ku dhowaad dhammaan cudurada of waxbarashada dhiigga aadanaha ayaa muujinaya in sicirka iyo AST, iyo ALT kordhay, la, heerka labada ensaymes ee kiisaskan waa ku dhowaad isku mid ah oo ay muujinaysaa joogitaanka cudurada. Laakiin waxaa jira weli waa kala duwan yihiin oo kale. Haddii heerka ALT kordhay in ka badan intii alanine aspartate, taasoo muujinaysa in Xilliga cudurku cudurka hepatitis B ah. Haddii ACAT dhiigga more, waxaa marar badan la dhibaatooyinka wadnaha.

In qof caafimaad ka kooban oo ka mid ah ensaymes gacanta waa in ay heer:

- in rag ilaa 41 halbeeg halkii litir (U / L);

- in dumarka ilaa 31 halbeeg halkii litir (U / L).

Si loo garto heerka ensaymes kuwaas, Dheef-protein, qaadan chemistry dhiigga. Norm for ALT dhexdeeda doono 28-190 nmol / (l c) ama 0.1, 68 mmol / (hr mL) iyo ACAT - 28-25 nmol / (l c) ama 0,1-, 45 pmol / (hr mL). Xeerkani waxaa labada kiis ee la siiyo habka of Reitman-Frankel (hab colorimetric cilmi).

Sida caadiga ah, baaritaan dhiig alanine aminotransferase sameeyay si ay u bartaan oo ku saabsan gobolka beerka, iyo alanine aspartate - si ay u arkaan gobolka ee myocardium ah (muruqa wadnaha). Haddii falanqaynta muujinaysaa ay dhiig oo sareeya, waxaa loola jeedaa in habka of burburinta iyo dhimashada unugyada ku dhacaa xubnaha kuwan. Sidaas daraaddeed, haddii AST dhaafto ay heer ee dhiigga ee 2-20 jeer, ka dibna waxaa suurtagal ah horumarinta Wadnaxanuun myocardial. Haddii heerka ALT kordhay, waxaa jira geedi socodka bahal ah ee beerka.

Under tilmaame hoos alanine aminotransferase dhiig iyo khubaro alanine aspartate ogahay in la'aanta jidhka ee pyridoxine (Vitamin B6). Sida caadiga ah taasi dhacdo inta aad uurka leedahay, la kelyaha soo noqnoqda iyo kelyaha.

Nasiib darro, ka serum dhiigga qofka caafimaadka qaba waa ensaymes kuwaas oo aan la garanayn, sidaas oo kale ayaa yihinn iyo farsamo ee ansixin (heerka xawaaraha ee daaweynta plasma ah, bioliquid kale iyo unugyada walxaha kasta sababtoo ah qeybiyey, biotransformation, tirtiridda jidhka ka).