ACE inhibitors - daroogo ku ool ah oo wadnaha casri ah

Celiyeyaasha ama ACE angiotensin diinta factor yeedhay vasodilators awood loo isticmaalo cudurada wadnaha lagu daaweyn jiray hypertension. tallaabo ah ee kooxdan oo ah daroogada waa sii dheeraaday ka xanibeen angiotensin hormone adrenal II - pressor factor weyn ee saameeya qiimaha cadaadiska dhiigga. celiyeyaasha ACE looga hortago burbur ee bradykinin, kaas oo sidoo kale saamayn xaaladda weelashii, oo halkan on height ee cadaadiska dhiigga. daroogada waxay kaa caawin in ay kordhiyaan heerarka dhiigga prostaglandins vasodilator u yareeyo calaamadaha wadnaha chronic, waxaa inta badan lagu arkay bukaanka qaba dhiig-karka lagama maarmaanka ah. Isla mar ahaantaana, celiyeyaasha ACE, ka duwan daawooyinka kale ee hoos u cadaadiska dhiigga leeyihiin saameyn ah kuma laha glucose iyo shiid la egyahay, la yareeyo kelyaha protein kaadida.

celiyeyaasha ACE waxaa loo isticmaalaa in ka badan 40 sano. The ugu horeysay ee kooxdan oo ah daroogada ee 1975 waxaa ku dhexsameeysmo captopril, loo isticmaalo maanta. A dhowr sano ka dib uu helay enalapril iyo lisinopril. Waxay la bedelay ka badan celiyeyaasha ACE casriga ah jiil cusub.

In wadnaha casriga celiyeyaasha ACE waxaa loo isticmaalaa sida daawooyinka ugu weyn ee lagu daweeyo ee hypertensive cudurka, cudurka wadnaha ischaemic, wadnaha chronic.

ACE inhibitors soocidda

Waxaa jira dhawr kala saaro of celiyeyaasha ACE, kaas oo ku salaysan yihiin kaxayntu ay jidka daroogada jidhka ka, iyada oo ku xiran kooxda kiimikada ee Britain ee la dhaqanka xarunta ACE tallaabooyinka waxqabad. kala soocidda ugu badan ee tallaabada pharmacological.

Sida laga soo xigtay tallaabada pharmacological of angiotensin diinta inhibitors arrimaha oo dhan waxa loo qaybiyaa saddex kooxood.

Kooxda hore waa captopril ama yihi, taas oo si toos ah uu hakiyo, i.e. hakiyo angiotensin aan diinta waxqabad ee hormone ee wajiga ku xiga - angiotensin II. Si ay u ilaaliyaan captopril ama kapoten dhiig karka caadiga ah laga qaaday saddex ilaa afar jeer maalintii.

Kooxda labaad ee ka tirsan enalapril, ramipril, trandalopril, tsilazipril, fosinopril, quinapril iyo daawooyinka kale ee soo jeesan ee jirka ku galay xeryahooda firfircoon in ay leeyihiin saamayn vasodilatory ah. daroogada Kuwani waa ku filan in ay qaataan mar kaliya maalintii.

Ugu dambeyntii, koox saddexaad wuxuu ka kooban yahay lisinopril Zestril, prinivil, prestarium ama perindopril. celiyeyaasha ACE waa koox saddexaad waxaa lagula talinayaa in mar ama laba jeer qaado inta lagu jiro maalinta.

Dhibaatooyinka ay keento celiyeyaasha ACE

Marka aad hesho kooxdan oo ah daroogo la socdaan horumarka suurto gal ah waxyeello ka soo gaartey. Xaaladaha qaarkood, qaadashada celiyeyaasha ACE muuqan kara qufac qalalan, kordhay dhiig, dawakhaad, finan maqaarka xasaasiyad, anjioedema heerarka potassium. dhibaatooyin Kuwan waxaa si buuxda u hartay ka dib bixitaanka daroogada. qufac qalalan u muuqataa in maalinta saddexaad-shanaad ee daaweynta. Its muuqaalka waxaa sabab u ah raasamaal ee sambabada ah bradykinin. Qufac baaba'aa si buuxda dib markii joojiyo of celiyeyaasha. Bukaanjiifka qaar ayaa hoos u dhici doono rabitaanka cuntada iyo rabshaysan tahay aragtida dhadhan.

Mid ka mid ah sababo waaweyn isticmaalka celiyeyaasha ACE waa laba geesoodka ah Cidhiidh halbowlaha kelyaha. Xaaladdan oo kale, dhiig karka waxaa kordhay korinta heerka renin in dhiigga taas oo daroogada waxay leeyihiin saameyn ah kuma laha.

daryeel gaar ah waa in la siiyaa celiyeyaasha ACE in cudurrada beerka iyo kelyaha chronic horumarinta calaamadaha la'aan, cagaarshowga iyo kelyaha.