"Quinidine": tilmaamaha loo isticmaalo, halabuurka, sharaxaad iyo dib u eegis

Maxay tahay sababta aan u baahan tahay qalab sida "quinidine"? Tilmaamaha loogu isticmaalo, qiimaha, iyo dib u eegis magacaabidda daroogada waxaa lagu hoos lagu soo bandhigay. Waxa kale oo aad baran doontaa wixii guryaha pharmacological caan ku daroogada, haddii ay tahay dhinaca tallaabo ah dabeecadda iyo in uu leeyahay wax xayiraad loogu isticmaalo.

The Halabuurka, qaabka, description

In foomka waxa shirkadaha dawooyinka ka dhigi daroogada "quinidine"? Tilmaamaha Isticmaalka, ku lifaaqan hab this, waa in laga iibsan karaa qaab kiniin guri oo ku wareegsan. Waxay leeyihiin saamayn dheer iyo film-dahaarka leh.

Walaxda weyn ee dawadan waa quinidine sulfate. Tilmaamaha, sharaxaad soo saarka ma bixin wax faahfaahin ah oo ku saabsan walxaha dheeraad ah.

Daawooyinka Pharmaceutical Products

Maxay yihiin kaniiniyada "quinidine"? Tilmaamaha loogu isticmaalo, sharaxaad, dib u eegista ayaa sheegay in ay tahay xal daaweyn for arrhythmia Class IA. Waa awoodo si aad u yarayso gaadiidka ee udhigo dhex channels Na derbiyada gacanta soonkii cardiomyocytes iyo in la yareeyo xadka depolarization xawaaraha iyo in la kordhiyo waqtiga dalka ay ku iman kara talaabada iyo madax adkaadeen (wax ku ool ah) dhererka waqtiga.

Reception ee medicament a attenuates excitability myocardial, gaabisaa automaticity iyo AV-tabinta in qanjidhada ah, block laan xidhmo, wadne iyo dhismayaasha kale. hab sidoo kale loo arkaa waxay leedahay saameyn vagolytic teedu m-anticholinergic saamayn, yaraynaysaa hawshu (contractility) muruqyada wadnaha iyo sababa hoos u cadaadiska dhiigga.

sifooyinka daroogada

Waxa la yaab ah daawada sida "quinidine"? Tilmaamaha loogu isticmaalo Hagidda in ay yeelan karaan saamayn inotropic xun. Tani waxay dhacdaa iyada oo sababtu tahay deceleration geedi socodka gudaha tamarta diinta ee mitochondria. Iyadoo la tixgelinayo guryaha antiarrhythmic of daroogada, waxay la xidhiidha joogitaanka kooxaha amide in qaab dhismeedka Britain oo ah walaxda firfircoon.

Sida laga soo xigtay khubaro ah, qaadashada ee medicament this waxaa si weyn u dhimay excitation iyo faafinta xawaare, kaas oo la xidhiidha soo-gaadhista ee qayb daroogada firfircoon habka depolarization.

Xakamaynta receptors m-cholinergic, tixgeliyaa daroogada wuxuu kobciyaa AV-tabinta. At qaadasho daweyn u muujinayaa guryaha hypotensive la xidhiidha hoos u midab xididdada durugsan iyo xididdada, iyo sidoo kale saamayn inotropic xun.

Waxaan ma dhihi karo in daroogada taas waa inay awoodaan inay muujiyaan saamayn diiqayo maxaliga ah. Waxaa sidoo kale wuxuu leeyahay sifooyin xanuunka iyo qandhada oo xiriirka la leh saamayn nixiyay maskaxda.

Sifooyinka pharmacokinetic ah

Nuugo in sida qayb firfircoon ee daroogada sida quinidine sulfate? Tilmaamaha loogu isticmaalo sheegayaa in soo dhaweynta ah wakiilka afka ah kor ay fiirsashada ugu weyn ee dhiiga 95 daqiiqo ka dib.

Reaction of this la borotiinada medicament ku saabsan tahay 77-80%. Its biotransformation dhacdaa beerka. Si kastaba ha ahaatee, qaar ka mid ah taagayo ayaa sameeyay talaabo cardiotonic.

The bar-nolosha ee qalab this waa qiyaastii 7 saacadood. Waxaa lagu daad gureeyay in kelyaha. By acidification of Digo kaadida medicament kordhay iyo markii ay alkalization - dhaxalsiiyeen.

Laga soo bilaabo waxa qoray?

Waa maxay calaamadaha muujinaya sida loo isticmaalo daroogada uu leeyahay "quinidine"? Tilmaamaha Isticmaalka dhigayaa in ujeedada daroogada inuu xaq yahay oo kaliya in arrimaha soo socda:

• at wadne- tachycardia, AV-tachycardias, extrasystoles ventricular iyo supraventricular, weerar ee wadne iyo flutter;
• si looga hortago weerarrada of tachycardia (supraventricular iyo ventricular), iyo aamba ventricular;
• ka dib markii artafiishal ah si ay u ilaaliyaan laxanka sanka.

Oo mamnuucday isticmaalka

Waa maxay xaaladda bukaanka diidina isticmaalka daawada "quinidine"? Tilmaamaha loogu isticmaalo (qiimaha daawooyinka hoos ku taxan) warbixino sababo of daroogada, sida:

• lama filaan ah cardiogenic;
• AV-block (degree labaad ama saddexaad);
• purpura thrombocytopenic, kaas oo diyaariyey ka dib qaadashada daroogada;
• disorder (daran) tabinta intraventricular;
• gunti block laan,
• sarkhaan digitalis, kaas oo la Ulasocto aan caadi ahayn tabinta;
• dareen xaasaasi ah in ay daroogada,
• daweeyay gravis.

Medicament "quinidine": tilmaamaha loo isticmaalo

Ogolaanshaha qalabka waa in gudaha 60 daqiiqo ka hor ama 125 daqiiqo cuntada ka dib la galaas oo biyo ah ka dib. Haddii aad rabto in aad si loo yareeyo saamaynta irritant of daroogada on xuub-axaleedka of mareenka dheefshiidka, waxaa lagama maarmaan ah si ay ugu bedesho biyaha caano.

daroogada dheer laguma talinayo in la calaliyo ama burburin.

qiyaasta caadiga ah waxaa loo arkaa 200-300 mg afar jeer maalintii. Haddii tachycardia supraventricular (la paroxysms) qadarka this u korodho si 400-600 mg 3 saac oo kasta ka hor inta gargaar dhamaystiran oo paroxysm. In wadne, medicament qaata 200 mg 2 chasa kasta (5-8 jeer maalin kasta). War sidee dose dayactirka waa 200-300 mg afar jeer maalintii.

daawada Alternative: 400 mg (haddii weerar lama soo xirtey, 200 mg ah) 60 daqiiqo kasta ilaa joojinta dhamaystiran oo weerarka, ama si ay u gaaraan qiyaasta a total of 1 g

Maqnaanshaha saamayn kaddib cabirka ugu horeysay ee soo dhawaynta ku xiga ee qadarka medicament in la gaarsiiyo 600 mg. Qaadashada daroogada ka badan 4 grams maalin kasta waa ka mamnuuc.

Keeneysa in loogu tala galay caruurta

In dose oo ah daawada carruurta "Dyuruls quinidine"? Tilmaamaha loogu isticmaalo, takhaatiirta carruurta ratings sheegayaan in qiyaasta caadiga ah ee wakiilka this ee ilmaha waa 6 mg / kg 5 jeer maalintii. Qorayaasha waa in ay ahaataa oo keliya dhakhtar khibrad leh, si adag on maragga.

Waxqabadka by-qof

Maxaa cawaaqib xun dhici kara isticmaalka daroogada "quinidine Durules" ka dib? Tilmaamaha loogu isticmaalo, sharaxaad ka mid ah daroogada this soo jeedisay ee dhibaato soo socda:

• asthenia, ballaarinta bareeg QRS ah, laga daweeyay gravis;
• ectopic garaaca ventricular, maqal la'aanta,
• rabitaanka cuntada oo luma, aamba ventricular, thrombosis halbowlaha, cadaadis dhiig oo hooseeya,
• rabshooyin muuqaalka, ventricular tachycardia, paroxysmal, tinnitus,
• asystole;
• lalabo, bradycardia sanka, hepatitis, calool xanuun, wareer,
• gastralgia, madax-xanuun, matag, Torombositobiiniya, shuban, madax wareer, anemia hemolytic;
• qandho, lupus-sida syndrome, finan maqaarka.

xaaladood oo badinta

Waa maxay calaamadaha of badinta keeni kartaa daawada "Dyuruls quinidine"? Tilmaamaha, comments ka khubarada la hadal oo ku saabsan daliilka sida tinnitus, niyad-jabka ah ee shaqada wadnaha, hoos u cadaadiska dhiigga, dawakhaad, flutter wadne, diplopia, shock quinidine, lumis maqal.

Si aad u baabi'iyo dalalka sida saameeyeen lavage qoray gastric, sahayda oxygen, wakiilada hypertensive, laso-, kelyaha iyo qalabka neefsashada.

isdhexgalka daroogada

Sida loo daaweeyo daroogada macaamila maalkii sida quinine? Tilmaamaha loogu isticmaalo (ee dib u eegista qiimaha medicament loo soo bandhigi doonaa dhamaadka maqaalka) sheegay in isku darka this kordhiyaa sumoobo labada.

Sidoo kale, kiniinka "quinidine" falgalaan daawooyinka soo socda:

• daroogada Antiarrhythmic kor loogu qaado tallaabo cardiodepressive.
• Anticholinesterase daawooyinka iyo daawooyinka kor loogu qaado saamaynta kalisodergaszczye "Quinidine".
• daroogada Anticonvulsant u dhimaan heerka dhiigga "Quinidine" iyo in la yareeyo ay waxtarka ay sabab u tahay kicinta ay dheef.
• Calool yareeyo oolnimada iyo ka-fiirsashada of daroogada ee dhiigga oo hoos u eegid.
• Daawooyinka alkalising kaadida, waxay kordhisaa khatarta ah in dareen diidmo oo sun ah.
• Daroogooyinka "amiloride" iyo "Amiodarone" yareeyo wax ku oolnimada "Quinidine" iyo dheerayn ay bareeg QT, siday u kala horreeyaan.
• Acetylsalicylic acid kordhiyay dhiig, petechiae iyo kor u dhiigbaxa xubnaha dheefshiidka.
• Medicaments "Warfarin" iyo "Verapamil" - wanaajiyey saamaynta daawada xinjirowga lidka ku ah ee heerka kowaad iyo labaad hoos u Digo.
• "Haloperidol" Drug - kordhisaa content ee dhiigga iyo kordhiyaa halista ah ee dhibaato.
• Daroogooyinka "hydroxyzine" iyo "dextromethorphan" - kordhisaa suurtagalnimada of arrhythmia daran ee soo dhaweynta ka mid ah koowaad iyo labaad ee dhiigga.

macluumaad gaar ah

Iyada oo digniin gaar ah qeexay daawada lagula talinayaa wadnaha stage failure 2-3, tachyarrhythmia (ventricular) la bareeg ah muruqa QT, Guntin Dalqada wadnaha, heerka 1aad AV-go'doominta, neefta, tayroodh, hypotension, cudurada faafa ee daran, emphysema , gulukooma xagal-xidho, hypokalemia, beerka, Torombositobiiniya, kelyaha prostate, chronic kelyaha, nuujinta, uurka iyo psoriasis.

Dadka qaba myocarditis iyo cudurrada kale ee myocardial markii la helo "Quinidine" control joogtada ah ee caafimaadka ayaa loo baahan yahay. Ka hor inta daaweynta, bukaanku waa inuu saxo ah calaamadaha hypokalemia iyo failure waxaa qalbiga ka soo.

therapy waxaa looga baahan yahay inay si joogto ah ula socdaan xogta ECG dhiigga durugsan iyo hemodynamics ah.

hab la mid ah, qiimaha

analogues Drug ka fikiray badan. Khubarada yeelaan iyaga habka soo socda: "Kinidin Durules", "Bretilat", "procainamide", "Etatsizin" "Lidocaine", "Amiokordin", "Propanorm", "Amiodarone" "Verapamil", "Propranolol", "Ritmonorm ".

Sida qiimaha daawooyinka sida "quinidine" iyo "quinidine Durules", ee dadkii waddankayaga degganaa oo, ay yihiin aan la garanayn ay sabab u tahay xaqiiqada ah in daawooyinkan yihiin mar dambe lagu iibiyo Russia. Si kastaba ha ahaatee, ay laga iibsan karaa in Ukraine. Qiimaha daroogada ee dalka ku saabsan yahay 540 iyo 670-679 hryvnia, siday u kala horreeyaan, taasoo la eg 1380 iyo 1760-1780 rubles.

Reviews

Waxa ay dadku sheegayaan oo ku saabsan dhakhaatiirta medicament tixgeliyaa iyo xirfadlayaasha kale? Sida laga soo xigtay iyaga, qalab this caddaynaysaa in la daroogada antiarrhythmic aad wax ku ool, waxa wanaagsan oo degdeg ah oo ku filan in lagu daweeyo cudurada sida ventricular iyo tachycardia supraventricular. Si kastaba ha ahaatee, waxaa la ogaadaa in search for "quinidine" pill farmasiyada Ruush suurtogal ma aha. Tan waxa u sabab xaqiiqada ah in dawadan waxaa laga saaray wareegga lacag la'aan ah iyo waxaa mar dambe loo isticmaalo cusbataallada. Dhakhaatiirta sharxi xaaladda this xaqiiqada ah in ay jiraan ammaan ah iyo in ka badan wax ku ool ah iyo sidoo kale dhigooda la awoodi karo in suuqa dawooyinka, kaas oo si firfircoon loo isticmaalaa ka muujinaya isku. Xaaladdan oo kale, khubaro ayaa sheegaya in quinidine sulfate joogto ah loogu isticmaalaa sida dastuurka ka mid ah walxaha multicomponent in dawooyin badan oo anti-arrhythmic.