PTH kordhay - sida ku cad falanqaynta?

hormone Parathyroid (haddii kale loo yaqaan hormoon parathyroid, parathyrin) - hormone uu soo saaray qanjidhada parathyroid unugyada (parathyroid), kaasoo ku yaala dhinaca anterolateral qoorta. Waxay ka dambeeyeen qanjirka thyroid, taas oo si dhow ku xiga si ay dusha danbe oo dhanba iyo qaybta hoose ee labada ay share. hormone Parathyroid in ay dabiicadda kiimikada waa walax protein adag - polypeptide taagayo acid amino.

Its shaqada ugu weyn waa in ay ka qayb iyo qawaaniin ah calcium iyo Dheef fosfooraska ee jirka. content ee calcium ee dhiigga iyo dheecaanka hoormoonka parathyroid yihiin si toos ah tiirsan midba midka kale ka. hormone The kordhin kartaa fiirsashada calcium ah by simaha on nudaha lafaha, kelyaha iyo mareenka caloosha iyo mindhicirka. parathyrin lafta kordhiyaa logoff kala diridda qayb macdanta by madadaalo Avv of falgalka gaar ah oo masuul ka ah burburka mid ah waxyaabaha laf yihiin. unugyada lafta waxaa sakhiray sarkhaansan resorption iyo calcium udhigo PTH ku yaalaan dhiigga. Wada jir ah ula paratgormot calcium sarrifka ka caawisaa in ay sharciyaynta heerka phosphate ee jirka. Yaraynta xoogga habka ugu horeysay noolaha, waxaa rizqiga socodka labaad. Waxaa intaa dheer, hormone waxaa ku lug lahaa hagaajinta Avv calcitriol ku jira xiidmaha, gacan ka nuugay calcium. hormone Parathyroid qaadataa qayb aan toos ahayn in xeer oo ka mid ah hawlaha oo dhan ensaymes calcium-tiirsan katalirizuemye ay dareen-celin. Under saameynta uu sidoo kale helo nidaamka xinjirowga dhiigga.

Haddii PTH waxaa Qolol, ka dibna aasaasay cudurro daran hormoonada jidhka ee la xidhiidha ku xadgudubka sharafta lafta - hyperparathyroidism, iyo lafo. Natiijada iin nafsaaniga ah sida soo maratay hoos u heerarka calcium dhiigga, taas oo horseedaysa in ay kor u kacay excitability muruqyada. Comorbidities kiiskan shaqayn karo content sare alkali ee jirka iyo horumarinta renal failure. By yareynta content ee calcium in gashto indhaha cataract dhacdaa.

Heerarka hormone ee ku dhaca qanjidhada parathyroid dhiigga ku xiran yahay laxanka ah kirkeydiyanka. Heerka asalka ayaa lagu wadaa at ah oo ku saabsan 8 subaxnimo, halka ee 14-16 saacadood ee maalintii, markii nin waa ay ugu sarreysey ee waxqabadka, hormone parathyroid kordhay. baaritaanka dhiigga waxaa lagu fuliyaa by tirada immunohemilyuminestsentsii parathyrin. Waxaa waa in calool madhan, iyadoo maalin ama laba ka hor sampling dhiig baabi'iyo qaadashada khamriga iyo jimicsiga culus dhowr saac ka hor howlqabadka, ha ku cabin.

On falanqaynta hormone parathyroid waxaa qoray oo keliya marka bukaanka ah lagu tuhunsan yahay jiritaanka cudurada sida barar aad iyo gipokaltsimiya, urolithiasis iyo halsiata. Sidoo kale muujinaya ujeeddo falanqaynta mid noqon kara: lafaha dhaadheer psevdoperelomy osteoporosis, nafsaaniga ah wax badala osteosclerosis lafta ama jirkooda vertebral oo looga shakisan yahay hormoonada jidhka badan nooca neoplasia 1 iyo nooc 2 (RAGGA 1.2). On heerka parathormone dadka waaweyn ah waxaa loo arkaa 9,5-75 bogga / ml. Tani waxay khusaysaa rag iyo dumarba da'da taranka. Haddii la ogaado in PTH la Qolol, ay jirto sabab kasta in loo qaato in bukaan-socodka uu leeyahay hoose, sare, hyperparathyroidism jaamacadda, pseudohypoparathyreosis ama Zollinger-Ellison syndrome.

Under kelyaha isku dhafan hyperparathyroidism hoose ee qanjirka parathyroid, kansarka jarayaa qanjidhka iyo neoplasia hormoonada jidhka laba nooc. Co. hyperparathyroidism sare waxaa ka mid ah kaafi chronic kelyaha, hypervitaminosis D, ulcerös kolit, rickets, cudurka Crohn. Haddii PTH waxaa Qolol, ka dibna falanqaynta waxaa badanaa laga sameeyaa in lala qeexidda heerka calcium ee dhiigga iyo in mustaqbalka la barbardhigo laba tilmaamayaal oo aqoonsadaan tiirsanaanta.