"Kosopt": tilmaamaha loo isticmaalo, dib u eegista. Analog "Kosopta" (indhaha lagu dhibciyo)

Waayo, daawaynta cudurada la xiriira kororka ku meel gaar ah ama joogto ah cadaadiska gudahood bu'da isha, taasoo keentay in hoos u dhac in waxloogu iyo atrophy dareemayaasha kala, codsan daroogada "Kosopt". Analogs isagoo ficilkan oo kale, waxaa laga yaabaa in kale wakiilka this.

description

daroogada waxaa laga heli karaa foomka of dhibco lagu shubo indhaha, sida medicament a antiglaucoma isu geeyey hoos cadaadis intraocular by yaraynta la sii daayo dheecaan dareeraha ee jirka.

In adag dejinta, dhibciyo "Kosopt" in qaab dhismeedka waxay leeyihiin laba Walxaha firfircooni. Mid ka mid ah iyaga ka mid ah, hydrochloride dorzolamide joogo qadarkuu of 22,26 mg halkii 1 ml, u dhiganta 20 dorzolamide saldhig mg. The qayb labaad firfircoon waa maleate timolol qadarkuu of 6,83 mg halkii 1 ml, taas oo u dhiganta 5 mg saldhigga timolol. In la abuuro xal u deggan waxaa loo isticmaalaa, walxaha dheeraad ah siinaya kaydinta diyaarinta nolosha shelf sheegtay. Kuwaas waxaa ka mid ah: xal 50% of chloride benzalkonium, sitraydh sodium, mannitol, hydroxyethylcellulose, xal hydroxide sodium, biyo arimaha debeda la isku duro.

Diyaarinta "Kosopt" dhibco lagu shubo indhaha, waa hufan, midab ama ku dhawaad midab, dareere wax yar viscous. Soo saaray in fijaan oo caag of 5 ml.

hab ay of tallaabo of tahay

Saamaynta Antiglaucoma ku salaysan saamaynta laba qaybood oo firfircoon: hydrochloride dorzolamide iyo maleate timolol. Mid kasta oo iyaga ka mid ah waxa ay yaraynaysaa dheecaan ka intraocular dheecaan, taas oo horseedaysa hoos u cadaadiska intraocular kacsantahay ee caadiga ah. Natiijada ay tallaabo wadajir ah oo qayb ka ah diyaarinta "Kosopt" (indhaha lagu dhibciyo) war sharaxayaa sida hoos u dhac dheeraad ah oo la cadeeyay in dhimaya this.

hydrochloride dorzolamide Action oo ku salaysan Iscelin ee la xushay ee anhydrase carbonic ay leeyihiin nooca II. hawlgalka tartiib ah u enzyme this yaraynaysaa dheecaan jidhka ciliary dareeraha indhaha ah, kaas oo la xidhiidha hoos u dhac in formation of udhigo bicarbonate, gaabis gaadiidka ee udhigo sodium iyo biyo.

Inta lagu jiro maamulka la mariyo ee hydrochloride dorzolamide galo nidaamka guud ee wareegga dhiigga. isticmaalka daba dheeraaday ee xarunta waxay keenaysaa in raasamaal ee u taagoo ay unugyada erythrocytic. Tan waxa u sabab ah ee doorashada ku qabanaya ah nooca labaad ee carbonic hydrochloride dorzolamide anhydrase, taas oo horseedaysa hoos u dhac in daroogada plasma dhiig qaab xor ah. N waa metabolite ah derivative -desetilnoe dorzolamide, oo waa awooda ku furid yar fahmayaan anhydrase carbonic nooca labaad marka loo eego tallaabada of qaab asalka ah, laakiin waxaa laga yaabaa Iscelin of anhydrase carbonic nooca ugu horeysay. raasamaal Metabolite sidoo kale dhacda in unugyada erythrocyte foom xudduud la nooc koowaad ee anhydrase carbonic.

Illaa 33% ee u taagoo ee ku xiran yihiin dorzolamide la albumin dhiigga. Derivation of qayb firfircoon iyo metabolites ay kaadida la sameeyaa. Kala noqoshada daroogada keenaysaa in Fansaarada saarista dorzolamide unugyada dhiigga erythrocyte. Bilowga ee daawaynta, hoos u deg deg ah ee ay ka kooban tahay, iyo markaas ka saarida oo ah walaxda firfircoon ee unugyada dhiigga cas waa la dhimay. Half-nolosha ka dib ku keento ee dorzolamide "Kosopt" tilmaamaha diyaarinta loogu isticmaalo wuxuu noqon doonaa ugu yaraan 4 bilood.

Features of tallaabo oo ka mid ah walxaha firfircoon

maleate Timolol muujinayaa sifooyinka of a non-xushay beta-xanibaha. Its doorka yaraynta cadaadiska intraocular la xidhiidha hoos u dhac in wax soo saarka iyo kor u saarista dheecaan intraocular ka bannaan ee.

Maamulka jirka la mariyo ee maleate timolol ee "Kosopt" dhibciyo raadad si mudida oo ah walaxda in nidaamka guud ee wareegga. The hypotensive saamayn of timolol bilaabmaa 20 daqiiqo ka dib markii maamulka, ay ugu badnaan saamayn timid ka dib markii 120 daqiiqo oo la hayaa min 1 maalin.

Tilmaamayaasha

tilmaan The aasaasiga ah ee daroogada "Kosopt" (indhaha lagu dhibciyo) waa glaucoma furan-iyo pseudoexfoliation leh calaamado cadaadis kordhay gudaha isha marka dheecaanka of dheecaan intraocular rabshaysan tahay. tallaabo ee medicament la faray in ay soo reebay iyo hoos u wax soo saarka ee qoyaan in ururto qolladaha ee isha, uu riixo on dareemaha iftiinka taasoo keentay in ay atrophy horusocod ah.

Sida loo isticmaalo

Diyaarinta "Kosopt" Codsiga User qoray codsan 1 dhibic si koleyga ee conjunctival ee indhaha bukaan-socodka ama ka hortagga ah ee labada indhoodba in 2 jeer maalintii.

Marka ujeedada daroogada this waxaa loogu talagalay bedelay dhibicyo hore loo isticmaalay ka glaucoma, ay u baahan yihiin si ay u joojiso isticmaalka for 1 maalin, ka dibna laga yaabo in hab cusub oo daaweyn ah. Xalka "Kosopt" maya si degdeg ah ka badan 10 daqiiqo ay maamulaan ka dib markii codsiga ah ee diyaarinta kale oo la mariyo indhaha.

Isticmaalka qalab this u baahan tahay addeecidda bukaanka tilmaamaha gaarka ah marka xal sterile ka hawlgala. Dhalada "Kosopt" dejinta (dhibco lagu shubo indhaha) la taliyaa hubiyo barashada ka hor furitaanka daacadnimada strip ammaanka.

fijaan oo la furin firaaqo u dhexeeya cap iyo dhalada. Si aad u furato strip cap waxaa loo baahan yahay in meesha laga saaro ilaalinta ka furitaanka.

Waayo, furitaanka cap dhalada waxaa unscrewed jihada tilmaamay by fallaadhiina waxay jiho, yaal daboolka.

Ka hor inta codsiga tooska ah ee daroogada bukaanka gana dib madaxiisa, uu jiidayo ku laayeen ee indhaha hoose, si ay u muujiyaan bannaan oo u dhaxeeya dusha hoose oo indhaha iyo bu'da.

dhalada rogay Next, iyadoo la isticmaalayo farta suulka iyo index waa in si taxadar leh ku tuujiyey meel, si gaar ah calaamadeeyay dushiisa of xumbo, in la sii daayay oo keliya hal dhibic ka mid ah xal galay indhaha ay dhibaatadu saameysey. Waxaa la aqbali karin ku saabsan qoorta dhalada in bu'da ama dusha sare ee qarnigii. Isticmaalka aan habboonayn ee dhalada sababa cudurada isha by wareer kala duwan, taas oo horseedaysa in ay cawaaqib xun khasaare dheeraad ah oo aragga.

Haddii labada indhoodba jirran yihiin, khalkhalgelinta kor ku tilmaamay in si la mid ah sida fuliyay mid kale.

Ka dib markii la isticmaalo waa in ay si adag u xidh furka furka dhalada, laakiin uma baahna in ay si adag u riix daboolka si aanay u dhaawici foomka dunta. Furitaanka meesha ugu sarreysa ee dareerka uu leeyahay ballaciisu yahay kaas oo u ogolaanaya isku duraa xal keento, sidaas darteed waa in aan ballaariyo.

dhibaato

Ayaa waxaa si fiican u dulqaadan daroogada "Kosopt" (dhibco lagu shubo indhaha), dib u eegista lagu qeexo waxyeelo ay yihiin kuwo aad u dhif ah. Marka barashada medicament ee daraasadda caafimaad ee dhibaato in u gaar ah isku darka this aan la duubay, laakiin waxaa lagu xusay waxyeelo hore u ogaan lahaa ee hydrochloride dorzolamide, maleate timolol iyo ka, laakiin calaamadaha kuwanu waxay ahaayeen fudud ee dabiiciga ah oo aan u baahnayn joojiyo dawaynta.

Baro daroogada "Kosopt" in tijaabo on mutadawiciin aadanaha ee 1035. Si 2.4% bukaanka dhibco lagu shubo indhaha lahaa in la joojiyo sababo la xiriira dhibic dhibaato in muuqday on xubnaha aragga. Waa in aysan suurtoobeen in daaweyn 1.2% mutadawiciin ah kuwaas oo arkay dhibaatooyinka maxalliga ah ee la xidhiidha diidmo iyo xasaasiyadda.

The daliilka ugu badan ayaa si toos ah ee la xiriira xubnaha hortiisa. Waxay muujiyeen dareen u ololaysa indhaha, nabaad corneal, aragga indhaha oo isku darsamay, indhaha-biyood.

Lifaaqsan daroogada "Kosopt" (indhaha lagu dhibciyo) codsiga User waxaa ka mid ah sharaxaad ku saabsan suurto gal kasin jawaab celinta ka kooban firfircoon ee xal daroogada, kuwaas oo geli karin galay wareegga guud.

Saamaynta of hydrochloride dorzolamide on xubnaha muujinta ku dhici kara qarnigii barar, cuncun iyo qolof maqaarka indhaha, iridocyclitis, keratitis dhibic, myopia ku transient. Isbeddelladan qaadan meel waqti qaar ka mid ah ka dib markii joojiyo daaweynta la daroogada this.

tallaabo hydrochloride Dorzolamide on habka dareemayaasha jirka by madax xanuun, wareer, xanuun dareen la kabuubyo, xanto-xanto oo ka mid ah maqaarka, daal, iyo asthenic syndrome calaamadeeyay.

Dareen-celinta xasaasiyadeed dhici kartaa foomka anjioedema wajiga, jirka, cudurka urtikaria, cuncun, dabac bronki, pharyngeal xabka cuncun, qallayl ee saabka afka.

Waxyeellooyin mariyo laga yaabaa goror hydrochloride dorzolamide.

Iyadoo hordhaca ah ee daroogada "Kosopt" waxyeello ka soo gaartey ka gaadhista maleate timolol indhaha u dhici karaa barar in xuub-axaleedka iyo wilka isha, caabuq ku laayeen ciliary ee indhaha ka, hoos u dareen ee wilka, xabka qalalan, disorder of toosan muuqaal, gashto oo yaraada Refractive ee isha, qeybsataan sanamkii la arki karo , ptosis ee indhaha sare.

The walax daroogada firfircoon waa maleate timolol, isagoo xanibaha beta ah waxay keeni kartaa falcelin dhinaca asalka ah ee kooxdan oo ah walxaha.

tallaabo ku saabsan nidaamka wadnaha iyo waxa lagu gartaa tinnitus, arrhythmia muruqyada wadnaha iyo wareegga dhiigga, dhiig karka, sii daridda ah angina, dabeecadda vasospastic, suuxid, wadnaha, barar unugyada, claudication, xanuunada dareemayaasha la kabuubyo, jidhidhico iyo jidhidhico ee maqaarka, calaamadaha Raynaud ee, gacmaha iyo cagaha oo qabow.

Maamulka jirka la mariyo ee maleate timolol sababa qufac iyo bronchospasm, gaar ahaan aadanuhu isagoo cudurada bronhoobstruktivnogo.

isbedel maqaarka ay keento tallaabo ee thymol, ee la xidhiidha khasaaraha timaha, finan psoriasiform ama sii daridda ah lesions psoriatic.

Tan iyo dareen diidmo oo xasaasiyadeed la xiriira muuqaalka Naxdinta anaphylactic, anjioedema, urtikaria, finan maxaliga ah ama guud on maqaarka.

maleate Timolol saameeya habdhiska neerfaha dhexe oo leh calaamado of wareer, murugada, hurdo xumo, xusuus lumid, daal muruqa striated.

walax dheefshiidka ayaa sababa shuban, absorbability oo yaraada, qalajiyo of xuub-axaleedka of ah saabka afka.

isticmaalka Features

Howl dhibcood "Kosopt", dhakhtarku waa inay hubiyaan ka hor in ay jirto ma failure of muruqa wadnaha dhigi. Bukaanka qaba cudurada daran myocardial ee la soo dhaafay iyo calaamadaha failure la joogo, inta lagu guda jiro daaweynta daawooyinka sida waa in la xilliyo gaar arkay by wadnaha iyo socdo heerka garaaca wadnahaaga. Daraysa ee wadnaha waxay u baahan tahay ka bixitaanka daroogada degdeg ah.

Waxaa jira xaalado dhimasho ka dabac bronki sababa maleate timolol dhibciyo "Kosopt" in bukaanka qaba neefta iyo wadnaha oo shaqadiisa gaba.

Saamaynta daroogada on dadka qaba cagaarshowga la'aan, laguma samayn daraasad si taxaddar loo baahan yahay ee daaweynta ee wakiilada antiglaucoma.

Arbushaada ah dheelitirka acid-saldhig ay sabab u tahay isticmaalka inhibitors anhydrase carbonic of eulayska, taas oo horseedaysa urolithiasis, taas oo inta badan uu yeesho in bukaanka qaba urolithiasis ee la soo dhaafay.

In daaweynta beta-blockers dadka qaba sonkorowga ama hypoglycemia, waa dhalanrog ka mid ah calaamadaha qaar ka mid ah caan ku hypoglycemia.

Beta-blockers, smoothes calaamadaha hyperfunction qanjirka thyroid ka, iyo la baabiiyo of qalab ka sii dari karaan xaaladda.

Ka hor inta qalliin soo socda iyadoo la isticmaalayo suuxin guud oo soo saarta joojiyo isha lagu dhibciyo muddo laba maalmood ah ka hor habka loo qorsheeyey in la yareeyo saamaynta timolol on dabcineyso muruqa iyo suuxinta guud.

Iyadoo qayb ka ah "Kosopt" dhibciyo waxaa chloride benzalkonium, ku simaha sida preservative, taas oo keeni kara indho cuncun. Marka la isticmaalayo contact lenses wada iyagoo diyaarinta ka hor waxaa lagama maarmaan ah in meesha laga saaro iyo saaray on 15 daqiiqo ka dib markii maamulka ee xalka. tallaabada of chloride benzalkonium keeni kartaa midabka ah malahan jilicsan.

Dhibaatooyinka ay keento isticmaalka daroogada adkayn wadista ama maareynta habab adag.

dhexgalka

blockers Calcium channel, beta-blockers, antiarrhythmics, glycosides digitalis, wakiilada kateholaministoschayuschie, parasympathomimetics, analgesics opioid'ka iyo inhibitors oxidase monoamine isku dhafan oo dhibco lagu shubo indhaha of timolol maleate ku salaysan bandhig saamayn hypotensive oo keeni bradycardia xadka ka weyn.

Go'doominta Beta-adrenoceptor systemic la xidhiidha hoos u dhac in garaaca wadnaha, ayaa lagu arkay dhexgalka ee maleate timolol la quinidine ama xushay inhibitor saameeya reuptake ee serotonin.

Dhexgalka ee maleate timolol la epinephrine keeni kartaa fidinta ardayda bukaan-socodka.

analogs

saaraha ee qoyaanka asalka ah "Kosopt" waa shirkad reer Holland "Merck Sharpe & Dohme BV", taas oo laboratories dhismeedka gaar ah indhaha oo ka mid ah laba walxaha firfircoon ee xalka la aasaasay (hydrochloride dorzolamide iyo maleate timolol) iyo qaybaha kaabayaal ah. Qalabkani waxa uu waxa uu helay codsiga ballaaran ee daaweynta ee gulukooma.

Shirkadda dawooyinka ee Romanian "LA Rompharm Company SRL "waxaa la soo saaray analoogga" Kosopta ", tusayaan kooban oo tayo iyo tiroba oo ka mid ah qaybaha firfircoon ee asalka ah. Labada daawooyinka waxaa soo saaray qaab indhaha lagu dhibciyo, waxyaabaha dhabta ah ee hydrochloride dorzolamide in xal qadarkuu of 22,26 mg oo 6,84 mg ah maleate timolol, laakiin waxaa jira farqi yar ee qaybaha kaabayaal ah. analoogga Available "Kosopta" magaca ganacsiga "Dorzopt Plus" ee. tallaabo ee daroogada asalka iyo daroogada generic faray at yaraynta priglaukome ah cadaadis intraocular, taas oo macnaheedu yahay in ay yihiin laysku beddelid karo oo ay ka maqan yihiin iibinta mid ka mid ah laga iibsan karaa medicament heli karaa farmashiyaha.

analog kale isha dhibco ah "Kosopt" soo saaray Croatian "Laboratory bb Yadran Galenski" loo yaqaan "Dorzotimol". Iyadoo qayb ka ah la joogo generic sidoo kale qadarkuu of dorzolamide hydrochloride 22,26 mg oo 6,84 mg ah maleate timolol, weliba, qaybaha oo dheeraad ah ay ku beeganto. Waayo, daawooyinka diyaarinta la mid tahay, sidaa darteed waxaa laga yaabaa in dropwise kale generic "Kosopt". Tilmaamaha loogu isticmaalo analogs isku jira waxaa hal group dawooyinka - "daroogada antiglaucoma." Tilmaamayaasha, habka codsiga, qiyaasta, dhibaato iyo xad dhaafka ah (calaamadaha) ee dhammaan saddexda daawooyinka waa u dhigma. soo saaraha ka dhigi kartaa Gudigga u gaar ah hanuun on isticmaalka dhibcood isha.

In diyaarinta "Kosopt" (indhaha lagu dhibciyo) analogs la mid dari karaa ama monotherapies, ka kooban labada hydrochloride dorzolamide ama maleate timolol. In kiiska qayb labaad firfircoon waa la isku daro analogues ma aha qayb ka mid ah daroogada asalka ah iyo tan sababa kala duwan ee ay ku oolnimada, waxyeelo iyo isdhexgalka lala qaato dawooyinka kale.

Monotherapy "timolol" ee foomka of indhaha lagu dhibciyo in 0,25% iyo 0.5% - analoogga "Kosopta" ku salaysan wax soo saarka maleate shirkad Indian timolol "Gen BRICK Pvt. Co., Ltd. '. In 1 ml ee wakiilka ka kooban maleate timolol (u dhiganta Timolol) 2.5 mg iyo 5 mg.

analoogga kale waa daroogada "Okumed" dhibicda isha Indian laba qiyaasood - 0,25% iyo 0.5%. saaraha ee tani waxay ka dhigan tahay "Promed Dhoofinta Pvt. Co., Ltd. ", India. In 1 ml xal "Okumed" sidii diyaarinta "Timolol", waxaa ku jira walax firfircoon timolol maleate 2.5 iyo 5 mg (u dhiganta Timolol).

isha analoogga Jarmal dhibciyo "Kosopt" daroogada ah "Arutimol" laba siyaalood - 0,25% iyo 0.5%, kaasoo lagu soo saaro by "Chauvin ankerfarm GmbH". In ka kooban ugu dhaco, sidii micne hore ku jira maleate timolol 2.5 mg iyo 5 mg (u dhiganta Timolol).

Sannadkii 2008, suuqa Ruush ayaa daawo la mid ah "Kosopt" analoogga ah "timolol-Akos" wax soo saarka ee Ruush ah ee warshad dawooyinka "Avv." Waxaa la soo saaray qaab isha Biyuhu hufan dhibciyo 0,25%. Halabuurka The wakiilka tani waxaa ka mid ah 2.5 mg ah ee timolol (foomka of maleate).

In diyaarinta "Kosopt" analogs bicomponent wadaagaan a qayb caadi firfircoon ee maleate timolol qadarkuu of 5 mg. Waxaa ka mid ah dhibic "Azarga" co-soo-saarka ee Belgium iyo ganacsi United Kingdom "Alcon Laboratories (UK) Ltd.". Halabuurka The oo xal this ka mid ah brinzolamide kale qayb firfircoon.

wax soo saarka kale oo la mid ah - "Fotil" wax soo saarka "Santen ao" (Finland) ee ka kooban kooban dhibco of hydrochloride pilocarpine at 20 iyo 40 mg ah maleate timolol iyo 5 mg.

analoogga kale "Kosopta" - ". Merck Sharp & Dohme BV" monotherapy saarka 'Trusopt' ah Walxaha ku jira hydrochloride dhibco dorzolamide qadarkuu of 2%.

Reviews of diyaarinta "Kosopt"

Isticmaalka wakiilada antiglaucoma waa wax aan macquul aheyn oo aan waxbarasho bilow ah dhakhtar. Cabbirka cadaadiska intraocular oo keliya bukaanka ma aha oo awood u leh, waxaan u baahan tahay qalab gaar ah, kaasi oo loo adeegsaday by dhakhtarka indhaha. Tilmaamayaasha cadaadiska sicir ahaa qolladdiisii oo sabab u yahay caga "Kosopt" dejinta (indhaha lagu dhibciyo). Reviews ku saabsan faa'iidooyinka daroogada, bukaanka ka tago ugu kala duwan. Waxa ugu weyn ee - si aad u ogaato ka dhakhtarka, sida loo isticmaalo daawada uu ka faa'iideysteen ama aragti soo gaartay. Daawada looga hortago laga yaabaa in horumarinta gulukooma ama ka caawin karaan calaamadaha ay.

On diyaarinta "Kosopt" dib u eegista bukaanka waa negative. Waxyeellooyin sida cuncun, gubashadeeda, indhaha oo casaada, waa sababta ugu for joojiyo daaweynta la dhibco lagu shubo indhaha. In ay taasi dhacdo, indhaha ku meelaynayaa isku diyaarinta, ka kooban kuwaas oo si gaar ah waxaa ka mid ah dorzolamide hydrochloride ama timolol maleate. cadaanyo suurto gal dhacaan oo keliya in mid ka mid ah qaybaha dhibic "Kosopt", Kurtumm bukaan on saamaynta daaweynta daroogada kasta kaa caawin doontaa in la saxo.