Daawada "Baraklyud": tilmaamaha loo isticmaalo, sharaxaad, halabuurka iyo dib u eegis

"Baraklyud" waxa loola jeedaa daawooyinka anti-retroviral, qayb ka mid ah kooxda analogues nucleoside. Qoray, waayo, daaweynta ee HBV-cudurka chronic. Walaxda firfircoon ee daroogada entecavir si deg deg ah lagu cabudhibayo taranka viral hepatitis.

waa in ay daruuri tahay in la bartay annotation hor qaadashada daroogada. Sida ka muuqata tilmaamaha loo isticmaalo? "Baraklyud" (Baraclud) - daroogada taas waxaa loogu talagalay si ay u bilaabaan soo noqoshada ah ee geedi socodka fibrotic in bukaanka qaba beerka cirrhosis.

daroogada

daroogada waxaa laga heli karaa laba hab qiyaasta - 0.5 iyo 1 mg qayb firfircoon entecavir muuqaal kala duwan ee midab dheeh (caddaan ama casaan, siday u kala horreeyaan).

diyaarinta ayaa sidoo kale waxaa ka mid ah:

• polysorbate;
• milmahayn magnesium,
• laktosmonohydrat lactose,
• Valium;
• povidone;
• colorant Opadry.

saamaynta pharmacological

Walaxda firfircoon waa entecavir taas oo analoogga ah guanosine ku nucleoside, ayaa kaga hadlay hawlaha la xushay si ay u hepatitis B.

Entecavir waxaa phosphorylated in triphosphate firfircoon la bar-nolosha ee ku saabsan 15 saacadood, ka kooban intracellular ah kaas oo la xiriira fiirsashada of entecavir unugyada ka baxsan. Marka ay tani aan arkay raasamaal appreciable oo ah walaxda firfircoon ee jirka. Daawo "Baraklyud" tilmaamaha loo isticmaalo taasoo muujinaysa in ay ku oolnimada sare, cabudhibayo waxqabad ee polymerase viral, saamayn isku mar on saddex arrimood:

• Avv qaybta wanaagsan ee DNA HBV,
• beddeli qoraal ah dunta negative mRNA pregenomic;
• HBV priming enzyme.

Triphosphate ma aha a retarders xoog leh ensaymes DNA gacanta, xitaa marka la content a ool ah oo saameyn ah kuma laha Avv DNA mitochondrial.

saamaynta daroogada

The walax daroogada firfircoon yahay oo awood u leh waqti gaaban la nuugo nidaamka dheef shiidka iyo gaadho ugu badnaan ee ku jira in 30-90 daqiiqo ka dib qaadashada kiniinka.

korodhka dhigma in Cmax iyo indices midowga afrika dhacdaa in isticmaalka xiga ee 0.1-1 mg ah medicament "Baraklyud". Tilmaamaha loogu isticmaalo hadalka ku saabsan gaaro dheelitirka ah maalinta 6-10-aad ee dhoos keli ah daawada maalin kasta. Isticmaalka cuntooyinka dufanka leh si weyn u adkaynaysaa habka nuugista entecavir, kalagoynta codes Cmax iyo midowga afrika by 45% iyo 20% siday u kala horreeyaan.

Daawada waxaa si degdeg ah nuugo in unugyada iyo 13% xidhxidhan u borotiinada plasma. The qayb daroogada firfircoon ma quseeyo muhashada, inhibitors enzyme ama inducers nidaamka P450. Waa inay awoodaan inay ku ururto jidhka iyo wax soo saarka iyada oo loo marayo nidaamka kelyaha by sifeynta glomerular iyo dheecaan embriyaha.

Tilmaamayaasha

Medicament "Baraklyud" talinayaa in ay qaataan daaweynta adag oo loo hepatitis B:

• Oo leh calaamado hadda taranka viral iyo kordhinta ahaa darajadii dhaqdhaqaaqa of transaminases ee serum ka, iyadoo ay wada joogaan ee daliilka histological barar socda beerka.
• lesions beerka Unrecovered.

gargaar la taaban karo calaamadaha cudurka beerka dhacaan ka dib markii maamulka daroogada "Baraklyud". diiwaanka Kiniiniga ku talinaysaa in bukaanka qaba cagaarshowga B ee joogtada, cudurka beerka adag by soo socda:

• ku yaal decompensated;
• xaalad beerka bahal ah in tallaabo magdhow ah marka lagu rakibay daliilka taranka viral cudurka of fibrosis beerka la AST kordhay iyo ALT.

sababo

Daawada "Baraklyud" uu leeyahay sababo soo socda:

• kor u nuglaato in entecavir iyo waxyaabaha kale ee ka mid ah Halabuurka daroogada;
• lactose la iska dhaxlo, glucose-galactose nuugeynin, deficiency ama maqan ee jirka ka mid ah lactase eulayska ;
• da'da ka yar 18 sano.

Dadka qaba kelyaha u baahan in ay qaataan daawada soo qoray iyo kormeerid caafimaad joogto ah.

Reception "Baraklyuda" inta ay uurka leedahay laguma talinayo inta lagu jiro daaweynta u baahan tahay si ay u joojiyaan naasnuujinta.

waxyeellooyin

Waxaa laga yaabaa in noocyo kala duwan oo ah cudurada of nidaamka dheefshiidka lagu jiro daaweynta daawada "Baraklyud". Tilmaamaha loogu isticmaalo waxaa si cad loogu tilmaamay waxyeelo:

• cudurada dheefshiidka,
• shuban;
• lallabo iyo matag,
• dyspepsia.

Waxaad sidoo kale la kulmi karaan madax xanuun, hurdo la'aan, ama hurdo, rabitaanka cuntada oo luma, iyo dareen diidmo oo xasaasiyadeed.

Dalbashada daawada sida wakiilka ah ku daweyn kaliya ama isku dhafan oo daroogo kale antiretroviral keeni kartaa hepatomegaly daran la tobnad, taas oo keeni karta in geerida bukaanka.

In bukaanka qaba lesions view decompensated laktatsiadoz dhici kara beerka, taas oo ah waxa lagu gartaa:

• tabar-dari muruq guud;
• neefsashada oo degdeg ah iyo muuqaalka kore ee neefta oo ku qabata;
• lalabo,
• hoos u weyn ee miisaanka jidhka;
• xanuun peritoneum ah, gaastari.

Sidoo kale, daroogada waxay keeni kartaa falcelin kala duwan oo jirka ka mid:

• heerka sii kordhaya ee transaminases cagaarshowga;
• finan maqaarka ah,
• reaction anaphylactoid.

The bukaanka ayaa sidoo kale qaba cudurka beerka decompensated, marka lagu daro, dareen diidmo oo kale waa u shaqeeyo muujiyey:

• renal failure (marmar dhif ah);
• kor u kacay content bilirubin in dhiig;
• . Cayimay dhiig xinjirowga ku tirinay 50 kun / mm ³ ama ka yar;
• yareynta bicarbonate dhiigga;
• siyaadiyaa ALT;
• in ka badan kordhinta saddex-laab waxqabad ee lipase;
• heerarka hoos albumin.

Medicament "Baraklyud": Qiyaasta iyo maamulka

Daawada waa in la qaato calool madhan, waqtiga ka cuntada ee la soo dhaafay ka hor kacmaha waa in ay ahaataa in ka badan laba saacadood.

Marka magdhow dhaawaca beerka dhaweynta talinayaa "Baraklyuda" 0.5 mg maalin kasta. In la aqoonsado caabiga qiyaasta lamivudine waa loo laablaabi.

Bukaanka qaba lesions beerka Derytii qoray qaato maalin of 1 mg. Waayo, dadka waayeelka ah iyo dadka qaba la'aan kelyaha, qiyaasta waa in la hagaajiyo ku xiran tahay heerka CK (fiirsashada kariyaatiniin) ee dhiiga.

badinta

Warbixin ku saabsan xaaladood oo badinta daroogada kuma filna.

Volunteers, kaas oo uu Caafimaad ahaan baaro, heleen qiyaasta maalin kasta of 20 mg muddo laba toddobaad ah la siiyo hal dose sare - 40 daroogada mg "Baraklyud". Tilmaamaha Isticmaalka dhigayaa in saamaynta xun ayaa la ogaan.

daaweynta posindromnoe talinayo iyada oo ay kormeerayaan daliilka kiliinikada.

Dhexgalka daroogooyinka kale

Sababo la xaqiiqada ah in entecavir ka qayb firfircoon saxarrada ugu horayn loo sii marayo Nidaamka kelyaha, therapy adag isku dhafan oo daroogo kale in ay bixiyaan saamayn toos ah ama aan toos ahayn oo ku saabsan shaqada kelyaha iyo saamayn dheecaan embriyaha, waxay keeni kartaa in la kordhiyo jirka ah ee entecavir iyo walxaha firfircoon ee daroogada.

Dhexgalka "Baraklyuda" la adenovirom, tenofovir, lamivudine aan la duubay.

tallaabooyin taxaddar

Aqbalaada bukaanka daroogada adkaysi u lamivudine keenaysaa in halista iska caabin ah.

Sidoo kale, waxaa jira caddayn ah dhacdo ee exacerbations ee hepatitis B ka dib markii joojiyo daroogada "Baraklyud". Tilmaamaha loogu isticmaalo sharaxayaa gargaarka ee exacerbations aan therapy dheeraad ah.

ganaaxyada

Reception "Baraklyuda" in qaabka guud ee monotherapy iyo daaweynta ay weheliso wakiilada kale ee antiretroviral, waxay keeni kartaa aysiidh jėrto, hepatomegaly la tobnad. Xaaladdan oo kale, waxaa jira halis ah oo dhimasho.

Halis bukaanka ka mid ah qaybaha soo socda:

• ka cabanaya hepatomegaly;
• in laguula dhaqmo iyadoo la isticmaalayo analogues nucleoside;
• isagoo u buuran,
• bukaan dumar ah.

Tilmaamaha loogu isticmaalo daroogada "Baraklyud" Hagidda suurtagalnimada of formation of nooc viral u adkaysta. Active daroogada entecavir qayb laguma talinayo oo lagu daweeyo fayraska dila difaaca jidhka, sababta oo ah ku-oolnimada jihada this aan weli bartay buuxa.

In daaweynta bukaannada qaba cudurada of nidaamka kelyaha, waxaa lagama maarmaan ah in la saxo qiyaasta.

The ammaanka iyo waxtarka la isticmaalayo "Baraklyuda" oo lagu daweeyo bukaanada ka dib markii xubin badalida beerka aan la garan doonin oo aan u baahan tallaabooyin waafaqsan daryeel gaar ah.

xaaladaha Kaydinta iyo kharashka

Kaydinta iyo gaadiidka ee kaabsal Waa in la fuliyo ee kala duwan heerkulka 15-25 ° C. Diyaarinta ayaa taam ah loo isticmaalo muddo laba sano ah laga bilaabo taariikhda la sameeyay.

Daawada waxaa ka mid ahaa in koox gaar ah ee daawooyinka lagama maarmaanka ah, iyo sababta oo ah qaybaha qaar ka mid ah muwaadiniinta dhigay bixinta free of daroogada "Baraklyud". Tilmaamaha loogu isticmaalo qabsatay xaqiiqda.

hab Price farmasiyada Moscow bilaabo 12 kun. rubles.

Views bukaanka

Waxay muujinaysaa waxtarka badan ee "Baraklyud" Buuggan daroogada edbinta. Price, dib u eegista ah taas oo muujisay in ay ahayd dimuqraadi ah marka la barbardhigo analogues of daroogada, kala duwan oo u dhexeeya 12-17 kun oo halkii xirmo, taas oo 30 kaabsal. Taas ayaa ka dhigaysa daroogada a aad loo jecel yahay iyo in baahida ka mid ah bukaannada daweynta hepatitis B.

In ra'yi-celin xun oo inta badan loo gudbiyaa proitvopokazaniya iyo kooxda saamaynta daroogada, sida hurdo la'aan, iyo lallabo.