Bisphosphonates - waa maxay? Bisphosphonates for osteoporosis

Nidaamka muruqyada qabata mid ka mid ah hawlaha ugu muhiimsan ee jirka aadanaha. waxaa Taasi waa taageero ah jirkooda oo dhan. caafimaadka Bone door muhiim ah. Marka ay jiraan dhibaatooyin kala goysyada, dhabarta, jab joogto ah ku dhacaan, tayada qofka nolosha waxaa si weyn u dhimay. Mid ka mid ah cudurka sida oo inta badan la socda calaamado sida waa osteoporosis.

Haddii wakhtiga si aad u aragto takhtar, waxaa suurtagal ah in si weyn loo hagaajiyo xaaladda bukaanka. Currently, bisphosphonates isticmaalo in lagu daaweeyo osteoporosis. Daawooyinkan waxaa ku siin karaan rajada daawo. Aan aragno waxa nooca daroogada.

Waa maxay bisphosphonates

Its magaca, kooxdan oo ah daroogada ayaa helay sababta oo ah content ee dhismaha laba phosphonates. hab ay of tallaabo wax ku ool ah uu ahaa sababta oo ah isaga egyihiin weyn la pirofosfonatami in ay leeyihiin saamayn weyn ku sharciyeynta content calcium lafaha ah.

Iyada oo qaab-dhismeedka la mid ah, bisphosphonates joogsada ensaymes in lagu amro kari pirofosfonaty. Waxay u muuqdaan in ay ku xidhaan udhigo calcium iyo iyaga dib ugu lafta ka dhaansado.

dhinaca wanaagsan ee isku soo dhoweynta ee daroogada waa in daawooyinka ay ku jiraan bisphosphonates, waxay leeyihiin oo kaliya saamayn la xushay oo ku saabsan nidaamka lafaha, halkaas oo raasamaal ah calcium.

Sababta oo ah tallaabo this ee daaweynta ee osteoporosis waxaa suurtagal ah si looga hortago khasaaraha ka mid ah calcium iyo fosfooraska, taas oo uu leeyahay saamayn togan ku saabsan daawaynta.

kala duwan ee bisphosphonates

Qaar badan oo weli ma oga saabsan bisphosphonates. Waa maxay? Waxa ay haatan u horumarsan iyo farcanka saddexaad ee kooxdan oo ah daroogada. Dhakhaatiirta sii wadaan in ay u isticmaalaan daroogada, iyo labada jiil ugu horeysay. Haddaba dawooyin badan oo ku jira muuqo bisphosphonates, oo kulligood wada ahaa waxa loo qaybin karaa laba qaybood oo waaweyn:

1. Simple ma ka kooban nitrogen.
2. Kooxdu waxay of bisphosphonates, oo ay ka mid nitrogen - aminobisphosphonates.
   

Farqiga u dhexeeya labada kooxood been in xaqiiqda ah in ay haystaan waxyeelo kala duwan on osteoclasts.

bisphosphonates nitrogen-ka kooban

Waa maxay? lacagtaas in ay ka kooban waxaa ku jira waxyaabaha soo socda:

1. Ibandronatovaya acid iska leh iyo farcanka saddexaad, dhexsameeysmo dhawaan loo isticmaalay aad si guul leh loogu talagalay ka hortaga osteoporosis in dumarka, gaar ahaan dhaleysnimada.
2. Zolendronovaya acid eegista u dhaqmo on nudaha lafaha, waxay leedahay saamayn anti-buro fahmayaan. On ku salaysan walax soo saaray daroogada this sida "Zometa", "Zolendronat".
3. correctors sodium Alendronate la xiriiraa-shiid aan ahayn hormoon ee unugyada lafta, kor u formation saxda ah ee qaab-dhismeedka lafta.
4. sodium Ibandronate on taas oo ay soo saaraan "Bonviva", "Boniva", "Bondronat" hakiyo dhaqdhaqaaqa osteoclast, laakiin waxba uma dhimeyso tiradooda. bisphosphonates Kuwani si loogu daweeyo of osteoporosis waa wax ku ool ah, gaar ahaan sida wakiilka ka hortag ah ee dumarka wakhtiga ma dhaleysnimada.
   

La soco in aad waa in aan is-Dawada, daawada waa in la dhakhtar soo qoray.

bisphosphonates fudud

Aan ku jiraan daawooyinka bisphosphonate nitrogen for osteoporosis ayaa sidoo kale si firfircoon loo isticmaalaa. Kuwaas waxaa ka mid ah:

1. "Etidronate" oo ah qaab kiniin iyo irbado. waxaa inta badan qoray osteoporosis ma aha oo kaliya, laakiin sidoo kale cudurada Paget ee, hypercalcemia, taas oo dhacda ku saabsan asalka ah ee kansarka.
2. "Clodronate" waxaa soo saaray qaab kaabsoosha, kiniin iyo xal. osteoporosis wax ku ool ah iyo osteolysis.
3. "Tiludronate" sida caadiga ah soo qoray ee dadka waaweyn ay dhibaatadu ka cudur Paget kaliya. Carruurta, waxa waa u.
   

Waxaa la rumeysan yahay in labadan kooxood ee daroogada leeyihiin saamaynta kala duwan ee lab iyo dhaddig jirka, si Mudanayaal qurux badan yihiin daawooyinka nitrogen-ka kooban habboon. Si kastaba ha ahaatee, doorashada waa in ay sameeyaan oo kaliya dhakhtarkaaga.

Oggolyahay in cudurro kala duwan

Waxaa jiro liis ku dhan cudurada taas oo therapy bisphosphonate yeelan karaan saamayn wanaagsan.

1. Osteoporosis.
2. Myeloma.
3. Deforming osteodystrophy.
4. hyperparathyroidism Hoose.
5. Ku xadgudubka nidaamka of formation lafaha.
6. Marka metastases lafaha.

Mid kasta oo ka xaaladahan oo kaliya dhakhtarka kuu qoray daroogada ah, oo ay qiyaasta iyo muddada isticmaalka. Ku hawlan is-daweynta, waxyeelayn kara oo keliya jidhka.

hab of action

Tan iyo bisphosphonates daroogo osteoporosis ah kuwa ugu ballaaran loo isticmaalo, waxaa lagama maarmaan ah in elucidate hab ay of ay tallaabo.

Dhammaan unugyada jidhkeena yihiin xilliyo updated, kaasaa sheegay kartaa oo ku saabsan lafta. Waxaa lagu hayo by dheelitirka ah osteoblasts, kaas oo masuul ka ah ereygu wuxuu ahaa ee unugyada cusub yihiin, oo osteoclasts ayaa mas'uul ka ah in ay u baabba '. Sidaas daraaddeed, BF bartey mucjisooyin caqabad ku shuqulka osteoclasts, iyo mararka qaar xitaa ay kiciyaan hab is-baabba '.

Waxaa la sheegay in xilliga hadda la joogo, culumadu aysan awoodin in ay si buuxda u ogaado sida loo maareeyo bisphosphonates burburinta block lafaha. Waxaa la og yahay oo kaliya in daawooyinkan la xidhay waxaa laga yaabaa in la hydroxyapatite in qaybo lafta, oon ku beddelo lafta laabaya.

Waxaad sidoo kale qori kartaa in haddii la isticmaalo muddo dheer, therapy in kansarka ku salaysan, kuwaas oo bisphosphonates xad dhow isticmaalo in lagu daaweeyo osteoporosis.

metastases Bisphosphonates

Iyadoo horumarinta ee kansarka yimaado marxalad marka unugyada kansarka ka fog burada hoose iyo faafinta jidhka oo dhan ayaa jebin. At meesha cusub ee ay ku xiran yihiin oo ay bilaabaan si ay u koraan, la xirrira metastases.

unugyada lafta waxaa si joogto ah la simay, sidaa daraadeed waxa uu kordhiyaa suurtagalnimada cudurka by hematogenous. Marka unugyada kansarka galaan ee dhuuxa lafta, waxay carqaladeeyo xidhiidhka caadiga ah inta u dhaxaysa osteoclasts iyo osteoblasts, taas oo horseedaysa horumar aan caadi ahayn unugyada lafuhu.

Tan iyo markii loo ogaado jiritaanka metastasis waa ay adag tahay, maxaa yeelay marxaladaha hore, habka this ficil ahaan waxay dhacdaa iyada oo aan calaamadaha, qaba kansarka waa inay ku aflaxaan imtixaanka dhamaystiran si loo ogaado iyo Axdigu sare.

Ka mid ah dhamaan daweynada metastases Bisphosphonates hubkaas ayaa loo isticmaalaa. Daawooyinkan waxaa si sahal ah loo dulqaatay by bukaanka, ay dhif ah oo waxyeelo badan.

Waxay waxaa la dhigan kara radiotherapy iyo chemotherapy. Marka la isticmaalayo daroogada sida lagu tilmaamay hoos u dhacdooyinka metastasis lafta ee kansarka naasaha, iyo multiple myeloma.

Marka uu yeesho hypercalcemia taas oo ku dhawaad caadiga ah ee cudurada oncological, daroogada saamayn ugu weyn oo ah qaab irbadaha iyo infusions. natiijooyin aad u fiican ay muujiyeen hab sida "acid Zolendronovaya", "Pamidronate". Durba dhawr maalmood ka dib markii bilow ah baaritaan daaweyn tusi calcium dhiig caadi, iyo saamaynta jiri karaa ilaa dhowr maalmood.

talooyin gaar ah oo qaata bisphosphonates

Haddii aadan maqlay oo ku saabsan bisphosphonates, waxa ay tahay, u sheeg dhakhtarkaaga. Aqbalaada daawooyinkan Waa in la fuliyo sida ay xeerarka gaar ah:

• Waa in aad qaadato daawooyinka ka dib baraaruga, ugu yaraan hal saac cuntada ka hor.
• Dhaq la biyo fara badan waa in.
• Ha isticmaalin zapivaniya dareere kale, sida juice, shaaha, kafeega. Waxay hortago nuugista ee bisphosphonates.
• Ka dib isticmaalka kiniinka been uma sheegi karo, waxay qaadataa qiyaas ahaan nus saac isagoo kor u jeeda in ay saameyn ku hunguriga ahaa yar.
• Waxaa laguma talinayo in la isu geeyo BF dhaweynta leh calcium dheeri ah, magnesium, birta iyo aluminium.

Haddii aad raacdo dhammaan talooyinka, bisphosphonate ma keeni doonaa waxyeelo aan loo baahnayn.

Bisphosphonates for osteoporosis: faa'iidada iyo khasaaraha

In daaweynta bisphosphonates badanaa loo isticmaalaa osteoporosis. Daawada waxa loo isticmaalaa si siman wanaagsan rag iyo dumarba. Faa'iidooyinka ugu weyn ee daroogada waxaa ka mid noqon kara:

• Waxa aanu hormoonno.
• Ha qayb-qaato horumarinta cudurada wadnaha.
• burooyinka halista ah iyadoo la isticmaalayo BF aan horumar.

Laakiin in kasta oo cadar ku jiro oo had iyo jeer waa suurtogal in lala kulmo Daqsi in marisay. Bisphosphonates, inkastoo ay isla oggolyahay ee daaweynta ee osteoporosis, weli waa ka fog kaamil ah. entrainment xad dhaafka ah ee soo dhoweynta ku siin karaan dhibaatooyinka soo socda:

• Si xun u saamayn beerka iyo kelyaha.
• Haddii intravenously maamulo, waxay u badan tahay in la horumariyo hypocalcaemia.
• Waxaa laga yaabaa in boog ku hunguriga ama caloosha.
• Waxaa jira finan jidhka ka mid ah.
• In qaar ka mid ah waxaa jira guud daciifnimo, qidmeyntiibulshada, iyo lallabo.
• Xanuun murqaha.
• Dhibaatooyinka Vision.
• Shuban ama shuban.
  

Waxaan ma dhihi karo in kuwan oo dhan Waxyeellooyin waa ahaantii isu muujiyay in bukaan kasta, laakiin waxa aad u baahan tahay inaad ogaato oo ku saabsan. Haddii aad tahay bisphosphonates qoray, waxa ay tahay, sharax dhakhtarka, ayuu dooran doonaa qiyaasta daawada la mid ah iyo muddada daawaynta.

daawooyinka noocan oo kale ah waa wax ku ool ah ee daaweynta ee osteoporosis iyo cudurrada kale ee. Ka hor inta aadan u yeelaan daawo, dhakhtarka ayaa loo baahan yahay si ay u fuliyaan baadhitaan si aad u ogaato gobolka shiid lafta iyo calcium homeostasis, sidaa darteed ma aha in aad qiyaasi daawo in kooxdan.

, Waxaad u baahan tahay inuu hogaamiyo hab nololeed caafimaad leh, raac oo dhan talooyinka dhakhaatiirta, midig si looga fogaado inaad door biday in ay daawada cuno. Kaliya kiiskan, aad nidaamka lafaha noqon doono ganaax.