Alpha-blockers: description iyo dirka

Thanks to cilmi berrinkii daawooyinka si joogto ah bartay tallaabada of daroogada, la sii daayo ka badan daawooyinka casriga ah-waxqabadka sare. Laakiin waxaa jira daawooyin badan oo kala duwan ee ay falsayeen in ay yihiin lagama maarmaan, waayo labaatan sano. Kuwaas waxaa ka mid Alfa-blockers.

Inta badan waxay ku waxaa loo isticmaalaa in lagu daaweeyo daroogada of hypertension, waayo yareynta dhiig-karka iyo sidoo kale tiro ka mid ah xanuunada urological, tus, prostatitis raaga iyo burooyinka Prostatic benign.

History of daahfurka

helitaanka Alfa-blockers in industry ee dawooyinka Ruush sameeyey 1976. Tan iyo markii ay loo arkaa daawooyinka wax ku ool ah oo loo yareeyo cadaadiska dhiigga. Laakiin si ay u isticmaalaan mar kasta ma ku habboon sababtoo ah waxyeelo aad u badan. Mid ka mid ah daroogada ee ugu horeysay ee group oo intaasu waxay ahayd "Prazosin". Next, waxaa la bilaabay wax soo saarka kale Alfa-blockers sida "Doksasozin" iyo "Terarozin". Dhamaan iyaga ka mid ah, iyo sidoo kale "Prazosin", loo isticmaalo in lagu daaweeyo hypertension, laakiin ka duwan waxa ay talaabo dheeraad ah oo ku daba dheeraaday.

Laakiin sidoo kale ku kala duwan yihiin heerka uu deegaamaynta ah ee meesha iyo ujeedada functional of Alfa-blockers. Diyaargaraw lagu hoos lagu soo bandhigay doonaa.

noocyada

receptors Adrenergic kala qaybsan yihiin laba dacawo:

• Alpha-1 receptors, kuwaas oo kooban dushiisa of xuub ee neuron ku postsynaptic, mas'uul ka ah calaamadaha adigoo isticmaalaya cinwaanka ah neurons kale catecholamine ama unugyada effector, oo ay ku jiraan unugyada vascular gaar ah ku qaadeen. natiijo hawshani ee receptors waa vasoconstriction.
• Alpha-2 receptors, kuwaas oo ku yaala xuub dusha of neuron kormeerka qarniga presynaptic of norepinephrine dillaacii synaptic ka via-celin xun, isla markaana hoos wax soo saarka ee noradrenaliin, wxbarashada dillaacii synaptic.

Hirgelinta Go'doominta receptor ee Alfa-1 vascular muruqa siman meesha vasoconstriction xanaajiyeen catecholamines. Taa baddalkeeda Alfa-2 receptors yaal xuub presynaptic of neuron ah, ma arkayey, ka dibna waxaa jira daacad ah hab-celin ah, oo iska xanaajin la sii daayo noradrenaliin.

Doorashada 1 (blockers) waa ku Doodeen ee receptors postsynaptic. medicaments noocan oo kale ah la baabi'iyo hawl receptor ay sabab u tahay saamaynta catecholamines sii daayay in wareegga ah, iyo neurons.

hawlaha

In saamayn intaas dheer oo ku saabsan hoos u cadaadiska dhiigga, blockers Alfa (daawooyinka hoos ku taxan) shaqooyin kale. Etokardialnye, dheefshiidka, saamaynta extracardiac daweynta. Sayniska oolnimada sare ee kooxdan oo ah daroogada ee daaweynta ee isbeddel ah ee myocardium ah, nidaamka wadnaha, ee saameeya borotiinada qanjidhka.

extracardiac

• Carbinta of kelyaha.
• Isdaahirinta oo ka mid ah dhuumaha dalka Portuqal.
• Hagaajinta ah hababka dheefshiidka ee nidaamka Fistula ee prostate buro-caanood.

Alpha-blockers leeyihiin saamayn togan ku yareynta koritaanka buro iyo heerka darnaanta ee impotence.

wadnaha

• Dhimista ee hypertrophy myocardial.
• Sharciyeyn garaaca wadnaha.

Si taxadir leh sababta oo ah saamaynta taban loo isticmaalo in wadnaha iyo angina.

dheefshiidka

• Loo yareeyo khatarta dabar kolestaroolka.
• Dhimaan heerka sonkorta dhiigga (insulin) ee dhiiga.

Sida kor ku xusan, inta badan Alfa-blockers isticmaalo in lagu daaweeyo cudurrada ee qanjirka 'prostate' in raggii.

Tirada dadka lab da'doodu ka weyn tahay 50 sano, inta badan xanuunsado tan iyo noocan ah ee cudurka, kuwii hore ka mid ah kuwaas oo prostatitis iyo prostate adenoma ah.

Cuduradan waxay ku leeyihiin saamayn taban ku leh hab-nololeedka qofka oo dhan. dhibaatooyin joogto ah marka la kaadinayo, raaxo, impotence horumar qaar ka mid ah dhibaatooyinka waayo, nimankii aad da 'kasta. Waxaa intaa dheer, cudurada kor ku xusan waxaa loo arkaa in la dhacyaan. Inta badan ma aan samayn karo qaliin la'aan. Si aad u joojiso cudurka daawooyinka wajiga isticmaalo ba'an.

Waayo-gelinta caafimaadka waxaa loo isticmaalaa a-blockers, inhibitors of 5-Alfa-reductase.

Scheme inhibitors tallaabo-ku-daweyn

koritaanka unugyada muruqa ee qanjirka 'prostate' la kiciyay horrayn hormoon. Steroid reductase 5-Alfa kor u saabka ee qanjirka 'prostate' Isbadal testosterone hormone galay dihydrotestosterone. Arintaan, markeeda, xidhana in receptor antiandrogen nuclear ee qanjirka 'prostate' iyo wuxuu kobciyaa dheecaan ah ee arrimood koritaanka paracrine, waxay sidoo kale u soo guuraya 'prostate'. Alpha-blockers, inhibitors of 5-Alfa-reductase ay awoodaan in ay ku caawiyaan in xaaladda this.

wax soo saarka xad dhaafka ah ee dihydrotestosterone keena tiro ka mid ah cudurada daran sida hypertrophy benign Prostatic, burooyinka kansarka, cudurrada kale ee prostate urological. Halkaa marka ay marayso in ay inhibitors isticmaalo 5-Alfa inhibitors reductase sida koorsada daaweyn caafimaad. Waxay saamayn ku daweynta waa reductase go'doominta, taas oo iyana hoos u heerarka DHT, kaas oo keena isbedel prostate waajihi.

The daroogo ugu caansan ee kooxdan yihiin "Finasteride" iyo "Dutasteride". Waxay leeyihiin saameyn la mid ah daweynta, waqtigooda feydnaanta kala duwan iyo mudada.

Blockers, inhibitors of 5-Alfa-reductase laga iibsan karaa farmashiyaha on qoro.

Laakiin in kasta oo ay ku oolnimada sare, daawooyinka loo isticmaalo si taxadir leh oo aan kiisaska oo dhan ay sabab u tahay tirada badan oo daliilka negative iyo sababo.

waxyeelo Major inta aad qaadanaysid

• Ka dib isticmaalka daroogada si ay cadaadis dhiig oo hoose u badan tahay inuu hypotension.
• Lallabo, madax xanuun iyo wareer.
• wadno, neefta oo ku qabata.
• Murqo xanuun, tabar.
• Suuxinta.
• dareeraha, barar.
• Xanuun caloosha iyo mindhicirrada.
• Sanka, neefta oo ku qabata, harraad.
• More inta badan qeybtii dhaddig oo dadka ayaa lagu arkay kicinta of tabar kaadi, kaadida oo soo noqnoqda.

Sidaa darteed, blockers Alfa-beta waa in la isticmaalaa si taxadir leh.

Mid ka mid ah cawaaqib ugu daran waa hypotension postural, taas oo qaadan kartaa meel hore u at dose hal. calaamadaha Her u horeeyay ka dib markii nus saac ah ama saacad kadib markii ay heleen medicament. Tani inta badan waxay khusaysaa "prazosin". Si looga hortago oo dhinacaasna waxaa saamayn, daroogada waa in la maamulo by sii kordhaya mudada iyo doorbidayaa habeen.

In xidhiidh la leh ee kor ku xusan waxyeelo ku xusan ee blockers Alfa qoray isku dhafan oo diuretics si looga hortago in dareeraha iyo xanuun joojiyaha in laga nafiso calaamadaha xanuunka.

Medicaments ee kooxdan lagu qoro sida daaweynta madax banaan ama isku mar lala qaato dawooyinka kale lagu daweeyo cudurada kala duwan.

cudurka

cuduro dhowr ah, oo lagu daweeyo oo Alfa-blockers waxaa loo isticmaalaa:

• In gacanta cudurada hypertensive in therapy isku dhafan iyada oo loo adeegsanayo si loo gaaro saamaynta ku daweynta degdeg ah.
• koritaan caanood ee qanjirka 'prostate'.
• Diabetes mellitus.
• Pheochromocytoma.
• neoplasm malignant qanjirka prostate ka.

sababo

In waxa kiisaska ma qori alpha- iyo beta-blockers?

The sababo weyn ee qaata diyaarinta waa:

• cadaadiska dhiigga oo hooseeya;
• fuuqbaxa;
• therapy la diuretics;
• curyaanimo wadnaha kala duwan;
• wadnaha chronic,
• neefta,
• rabshooyin garaaca wadnaha.

Ha qoro daawooyinka noocan ah ee uur ah iyo inta lagu jiro nuujinta, sida waxbarashada shaybaarka sax ah oo ku saabsan mowduucan ayaa la sameeyay.

Alpha-blockers adenoma

daawooyinka aasaasiga ah ee kooxdan waxaa loo isticmaalaa daaweynta adenomas:

• "Uroksataral".
• "Cardura".
• "Gitrin".
• "Rapaflo."
• "Flomaks".

In xogta ah daawo Alfa-xanibaha. Liiska tagaa on.

hab of action

hab ay of tallaabo daroogada, kuwaas oo dagaalka ka dhanka ah adenoma waa mid fudud, waxay qaadan midab ah ee muruqyada ee prostate iyo kaadi haysta, taas oo caawinaysa in la yareeyo kaadida.

Qori Dabcan daaweyn daawo oo kale oo leh qiyaasta shaqsiga, qaadashada hal ama laba jeer maalintii.

Qori qaybaha daawo bukaanka qaba cudurka sare ay ku adag tahay marka la kaadinayo, iyo daroogada taagta daran ma saamayn la doonayo.

The saameynta ugu weyn ku daweyn bilaabaa inuu ka muuqan toddobaadkii daawada ka dib. In 14-21 maalmood jiro gargaarka muhiim ah in bukaanka.

ganaaxyada

Waayo saamaynta ku daweynta sare helay in labo ka mid ah Alfa-blockers iyo inhibitors of 5-Alfa-reductase. oolnimada sare ee isticmaalka diyaarinta aaday helay iyadoo ay sabab u cilmiga caafimaad oo caafimaad.

Waxaa laguma talinayo in la isugu daro daawo kor ku xusan ee hada daawooyinka ama impotence BADami. kor loogu qaado karaan blockers saameyn ku daweyn, taas oo aan loo baahnayn. cidhibtii noqon karaa hoos u dhac af ee cadaadiska dhiigga.

natiijo kale oo xun ee maamulka blockers Alfa Urologicals biyo bax laga yaabaa in saabka kaadi haysta. Waxay keentaa ma cawaaqib xun ee caafimaadka guud.

Marka la isticmaalayo kooxdan oo ah medicaments waayo, la dagaalanka adenoma talinayaa si loo yareeyo daroogooyinka kale cadaadiska dhiigga. Aqbalo sida element ah therapy adag, waxaa laga yaabaa in ka yar wax ku ool ah ee daaweynta ee hypertension.

Bukaanka cudurka hypertensive qaba marka la isbeddelka ka dhacay qanjirka 'prostate' Alfa-xanibaha qabashada waxaa lagu talinayaa in si joogto ah loola socdo heerka cadaadiska dhiigga.

Taxadarka markii qaadashada daawooyinka

• Daawooyinka la blockers Alfa isticmaalaan oo kaliya uu dhakhtarku soo qoro. dhakhtarka waa in loo ogaado qiyaasta, mudada soo dhaweynta.
• Daaweynta daawooyin ahaan iyada oo ay kormeerayaan dhakhtar ama xarun caafimaad ee derbiyada.
• Marka muujinta waxyeellooyin in aad joojiso qaadashada daawada iyo la tasho dhakhtar.
• ma Xaaladdan oo kale ma beddelo qiyaasta kor madax banaan.
• daawooyinka kale isku mar la Alfa-blockers in ay raacsan tahay dhakhtarka.
• Ha isticmaalin Alfa-blockers sida daaweynta degdegga ah ee xanuunada hypertensive ah oo aan wax ogolaansho ah dhakhtar.
• Ha aqbalin daawooyinka dhacay ama xirxirida daciif ah, waxyeello ku kiniinka qolof adag.
• daroogada Iibso gaar shati farmasiyada.
• Marka la helo kooxda kor ku xusan ee daawooyinka si joogto ah oo dhan maalinta iyo wakhtiga hurdada si loo cabbiro cadaadiska dhiigga.
• Qaadashada daawada cadaadis dhiig oo sareeya inta ay uurka leedahay, hubso in aad raacsan tahay dhakhtarka.

Waxaa muhiim ah in la fahmo in badinta daroogada, kuwaas oo keeni kara in ay cawaaqib aan loo baahnayn.