Waa maxay daawada anti-TB waxaa sida ugu wanaagsan loo isticmaalo daweynta?

Baarin qaaxada sambabada waa la daaweyn karaa muddo 10 bilood ah jadwal si ay 1.5 sano gudahood. Ilaa goormaad daaweyn waxay ku xiran tahay darnaanta nidaamka cudurada iyo magacaabidda daroogada dawaarle-dhigay ugu haboon.

Tuberculosis in aannu mar - cudur la dawayn

In therapy antibiotic qaaxada casriga ah waxaa xuquuqdeeda leh ee daawaynta isku dhafka ah. Tani waa sababta oo ah marka la helo hal mar oo ah daawooyinka kala duwan waa badan gaabis ah u koraya iska caabin dee- in daroogada. Bukaanku waxa lagu qoray koorso isla markiiba Saacadda 2 ama 3 daroogada. Nasiib wanaag, fursadaha daawada maanta waa ballaaran. Tani waxay noqon kartaa oo kaliya tiro ka mid ah 1 daawooyinka TB ama isku-dar ah daawooyinka la isku daro waxaan iyo II taxane.

Qoondaynta oo ah wakiilada anti-TB dhisay by heerka uu waxtarkooda. By habka, si ay u Machadka Cilmi-our mahad badan oo la alifay ee daawooyin sida "INH". Tani waa mid ka mid ah daroogada ee waaweyn anti-qaaxada, waxa ay leedahay faa'iido ah hawlaha bacteriostatic mid aad u sarreeya. Xaaladdan oo kale, waa farsamo gaar ahaan wax soo saar leh ee bukaan dhowaan laga helay jiradaas.

liiska Next

The-oolnimada labaad ee daawaynta ka dib "Isoniazid" - waa "Rifampicin". hab aad u qurux badan oo wax ku ool ah. diyaarinta xiga Active la qoondeeyey karaa in isku xigxiga ee soo socda: "streptomycin", "Kanamycin", dheeraad ah "Pyrazinamide" "Ethionamide" raacay by "Prothionamide" "Ethambutol", iyo 3 dheeraad ah 'florimitsina "" Pask, "TB "Thioacetazone" daroogada.

Dhammaan daawooyinka vozdeystuyuschie in Mycobacterium iyo xaliyo dhibaatada caafimaad ee bukaanka ayaa laga saaray kooxda daroogada anti-TB:

1. daawooyin lid ku ah bakteeriyada anti-TB waaweyn 1 taxane
2. daroogada reserve II taxane.

The diyaarinta kala duwan 1 iyo 2 saf

In safka kowaad waa daroogo ugu weyn oo sheeganayay inay hufnaanta ugu sarraysa oo ka mid ah wakiilada kiimikada, iyo taagayo ay. Hayso sumoobo yar.

daroogada Antituberculosis 2 saf, oo ay ku jiraan daroogada gurmad, ma waxay leeyihiin sida natiijo fiican ee la dagaalanka Bir Koch, iyadoo ilaa xad sun ah. Waxay waxaa maamula in bukaanada ay dhacdo in haddii jidhku waa boogeed dawooyinka tirada 1 ama dulqaad daawooyinkaan waxaa la arkay.

statistics Sad muujinaysaa in mar kasta oo daroogo la qabatimo jidhka, i.e. tayada waxa aad u yaraynaya. Sidoo kale, daawooyinka anti-TB weyn ee waqti cayiman ka dib, waxay keeni naftooda iyo qabatimo sababtoo dee- noqdaan difaaca iyaga. Tusaale ahaan, haddii karantiimada aqbali daroogada gaar ahaan mid ka mid ah oo kaliya, ka dibna iska caabin ah in ay dee- arkay 2-4 bilood gudahood.

daawooyinka TB: isticmaalka xoog iyo saamaynta

Inta badan weerarada TB daroogada saamayn bacteriostatic on dee-, in uu yahay, waxay yareeyaan qatarta iyo jebin suurtagalnimada in lagu dhufto. Sidoo kale, "INH" iyo "Rifampicin" in qaadasho xoog awood u leeyihiin inay wax ka qabtaan bactericidal. Si aad u hesho saamayn caafimaad oo xasilloon, iyo sidoo kale si uu ugu digo iyo iska indha xoogeystay suurto galka ah ee daroogada anti-TB waa in la sii waqti dheer.

Iyada oo dhammaan ka mid ah xulashada iyo magacaabista isku darka ugu fiican ee daroogada, iyo sidoo kale muddada ay codsiga waa si toos ah ay ku xidhan tahay ka qulqulka bukaan socodka ee foomamka waqtiga qaaxada in, by waxa hab lagu qaaday daaweynta hore (haddii ay jirto), sida loo dulqaatay by bukaanka daawooyinka qaarkood ka sida Mycobacterium tuberculosis u nugul yihiin daroogada la doortay.

waafaqid fiican

Isku daroogada anti-TB qorsheeyay on male ah in uu barnaamijka daaweynta waa in ay ahaadaan mid la joogo ama laba daroogada-line ugu horeysay. Dabcan, haddii aysan haysan wax sababo ama u muujiyaan xasilooni. At dose this dhan diyaarinta isku daro guud ahaan ma la dhimay.

Marka uu u xilsaarayo (ftiziologa qoraal) waa in la tixgeliyaa in sida daroogada ah anti-TB, sida streptomycin iyo taagayo ma lagu dari karaa florimitsina, kanamycin iyo antibiotics kale in ay leeyihiin saamayn nephrotoxic oo iyadana.

Waa maxay nooca diyaarinta "PAS"

"PAS" - daroogada TB saamaynta bacteriostatic. Haa socon maalmo saynisyahano pharmacologists yaa abuuray. Aad u firfircoon ka dhanka ah bacilli TB. Wax ku ool ah in daaweyn jiray noocyo kala duwan oo localizations kala duwan ee cudurka qaaxada. Waxaa siinayaa saamayn xataa si fiican marka la isku daro leh magacaabidda tallaabo kale TB daroogada.

daroogada waxay leedahay magaca Laatiin "PASK-AKRI". Available ama jawaan oo 4 g ama 100 g at bangiga in a bacda dawada "PAS" ku jira 3.2 sodium aminosalicylate, sida hal kiniin ah - 1 g of sodium para-aminosalicylate. Kiniinnada daboolay madfac ilaaliyaa caloosha iyo in la iibiyo waxaa la geliyaa ilaa for 50/100/500/1000 gogo '. baakadda.

Maxaa ka fiican in la isu geeyo

daroogada TB "PAS" marka la eego tuberkulostaticheskoy dhaqdhaqaaqa daawooyinka liita sida isoniazid iyo streptomycin, iyo sababta oo ah waa in lagu lala isticmaalaa a wakiilada firfircoon. therapy isku dhafan caanuhu horumarinta adkeysiga daawada iyo wanaajisaa saamaynta daawooyinka saameen.

Pharmacokinetics "PAS"

daroogada waxay leedahay sare ah (90%) ka mid ah nuugista. Waxaa la metabolized beerka. Awoodaan in ay si fudud u dhex gelin ah caqabadaha-unugyada dhiigga iyo qaybiyey unugyo ah. Heerka ugu sareeya ee fiirsashada daroogada lagu arkay sambabada, kelyaha iyo beerka. More dhexdhexaad ah "PAS" (daroogada antituberculosis) guskiisa galay dheecaan lafdhabarka. Laakiin in ay dhacdo caabuq ee qolofka cerebrospinal fiirsashada acid aminosalicylic waa 10-50% of-fiirsashada ee plasma dhiigga. Inta badan (80%) ka mid ah daroogada raaca inta badan kaadida.

Diyaargaraw II taxane

2 daawooyinka anti-TB at dhowr ah oo iyaga ka mid ah in ay doortaan iyo ballan waqtiga leeyihiin saamayn wanaagsan ku daweyn la eego naanin, oo lagu daray ayaa sidoo kale u dhaca weyn ee isbedel bararka ee unugyada sambabada, iyo xitaa in daaweynta qaaxada ee bronkie.

Sida laga soo xigtay cilmi caafimaad inta lagu guda jiro lagu daweeyo carruurta iyo dadka waaweyn ee foomamka adag, chronic iyo burbur of dhacdo qaaxada la isku kala duwan ee daroogada dhowr II ee, la siiyo bukaanka iska caabin ah rugaha caafimaadka, iyo muruq u adkaysta bakteeriyada daawooyinka aan taxanaha, in boqolkiiba 65 ka mid ah xaaladaha waxaa la helay, taas oo ah mid aad u farxiya , saamayn caafimaad oo dheeraad ah.

daawooyinka TB: waxyeellooyin

Iyo, dabcan, xiiso kuwa daawooyinka qaadashada waxa lagu sharaxay maqaalka, oo ay suurto gal waxyeelo. Gaar ahaan, sababtoo ah soo galay sannadihii ugu danbeeyay ku dhaqanka daawada daawooyinka anti-TB mudan yihiin tixgelin gaar ah. Tan waxa u sabab xaqiiqada ah in cudurkan ugu dhakhsaha badan u tallaabay doono marinka safmarka ah, inkastoo la taaban karo ka dib dagaalkii labaad ee dunida si loo yareeyo heerka cudurrada. Sidoo kale muhiim u tahay xaqiiqada ah in daaweynta qaaxada, sida kor ku xusan, hannaanka waa wax dheer, iyo saamaynta taban ee daroogada kaliya laftiisa muujiyey, ama badinta ama inta lagu jiro sii dheeraaday oo uu soo dhaweynta.

Qaar ka mid ah tirakoobka

Marka diiwaanka sheegi therapy TB shisheeye iyo wakiillada gudaha daawo waxyeelo ah daawooyinka iyo inta jeer ee dhacdo si duwan ah, sida dabiiciga ah ee cudurka. Tusaale ahaan, ka 3148 bukaanada daaweyn in ku lug wakiilada firfircoon ka dhanka ah dee-, dhibaato ayaa lagu arkay% dadka kaliya 12.2, iyada oo inta badan oo ka mid ah waxa uu ahaa muujinta dabiiciga ah xasaasiyad, iyo kaliya in 74 bukaan oo waxaa jiray sumoobo sunta.

Iyada oo ku saleysan xogta la daabacay, waxaannu ku tirinnaa karaa in dhibaatooyinka la fiirsanayo ee daawooyinka anti-TB jawaabaha inta jeer oo kala duwan. isbedbedelka badan oo lagu sharxay sida ay ula macaamilayaan non-uniform of xaaladaha muhiimka daroogada ma aha oo kaliya loo isticmaalo, laakiin sidoo kale nooc ka mid ah cudurka qaaxada, iyo sidoo kale da'da bukaanka, xitaa noocyada xarumaha caafimaadka (isbitaalka, sanatorium, rugta caafimaadka, hay'adda).

cilmi sii

Daaweyntu waxay waxyeello u Bacillus Koch ayaa, waxaa ka mid ah tiro ka mid ah xeryahooda dabiiciga ah iyo semi-synthetic taas oo ay jirto hal shay ee caadiga ah - waa hawl ay ka gees ah, ie Mycobacterium tuberculosis (M.tuberculosis). daawooyinka TB, kala soocidda, kaas oo, sida hore ee qodobkan ku xusan, kala qaybinaya daawooyinka galay 2 taxanaha (hoose iyo gurmad), waxaa ka mid ah xiiso weyn u saynisyahano.

fiiro gaar ah waa horumarinta iska caabin ah bacilli TB. All baaritaan shaybaar ayaa la fuliyaa, oo arrintan natiijada muujisay in inta badan bukaanka heerka adkeysiga daawada inta lagu guda jiro daawaynta kala duwanaan karaan, iyo intii ka sii weynayd oo midhona, gaarey ugu jeer in ay dib u soo celinta gebi ahaanba dareenka.

Dhimista ka mid ah dhibaato

Marka dhacdooyinkan gurracan ee dhaca inta lagu jiro daaweynta, marka ugu horeeysa ee daawada in la dhimay ama in la bedelo qaar ka mid ah diyaarinta kale. In dhinaca kiiska reaction daroogada antituberculous daran ku meel gaar ah mamnuucaan soo dhoweynta la bedelka xiga by kale. Si looga hortago oo loo baabi'iyo calaamadaha bukaanka cudurada wadnaha lagu meeleeyo ku xiran tahay xujada mid ka mid ah tiro ka mid ah antispasmodics daroogada, sida: "Eufillin", "papaverine", "Teofedrin" dhibciyo "Zelenin," iwm ...

Astaamaha iyo adkaanta dhacdooyinkan gurracan ee lagu jiro daaweynta TB waa kuwo kala duwan. daroogada Antituberculosis, kala soocidda, taas oo daliilka gaarka ah ee feature isla kiimikada, wada raaciyaa si loo fududeeyo cilmi.

daaweynta TB

In daaweynta cudurka tuberculous in aannu mar waxa ay sidoo kale waxaa loo arkaa hawl muhiim ah si looga hortago faafidda cudurka. Hanjabaadaan ayaa timid ka bukaannada qaba tiibishada sambabada qaab furan. Ay daaweynta degdegga ah ka caawin doona in la yareeyo tirada cudurada, iyo sidoo kale in ka hortaga xaaladaha cusub ee cudurka this xun.

Tan iyo daaweyn muddada-dheer, bukaanka qaadataa badan oo samir iyo samodistsiplinirovannost. Indeed, qaaxada waa dhaawici ma aha oo kaliya ku dhuftay by jidhka, laakiin sidoo kale jidhka oo dhan oo dhan. waqti aad u muhiim ah si ay u bilaabaan therapy antimicrobial, taas oo dabcan waa madaafiic ugu awoodda badan, daawooyinka TB estosnovnye. Thanks iyaga, weli joojinta suurto galka ah ee bacilli ku jira marxaladaha hore, kaas oo ka qaybqaadan doontaa dib u soo celinta xubnaha ay dhibaatadu saameysey dhaawac ama wax yar si ay u shaqeeyo oo dhan.

daaweynta Comprehensive in loo maamulo iyada oo la tixgelinayo da'diisa iyo foomamka loo aqoonsaday cudurka, waxaa ka mid ah saamaynta on habka bahal ah ee xubin ka buka, yareynta calaamadaha saameen (xanuun, qufac) oo ku neefsasho kala duwan iyo farsamooyinka daaweynta jirka.

Kooxda Admission loogu talagalay daawooyinka waa in ay daruuri noqon caadiga ah sida hab Kai keeni kartaa horumarinta iska caabin ah iyaga ka. Daaweynta waa in lagu sameeyaa isbitaalka iyada oo ay kormeerayaan dhakhtar. Ka dib markii phthisiatrician dheecaan si taxadar leh loola socdo.

Habka iyo hirgelinta daawada iyo ujeedooyin caafimaad oo halis ah waa furaha si loo dhamaystiro dib u soo kabashada. Maalmahan TB ma aha xukunka.