Unugyada DNA double-ku xayiran - gaar ahaan xeerarka iyo decryption

Anti-dsDNA (antiDNK) ama antibodies double-ku xayiran DNA waa koox Nuurre Aw of unugyada DNA double-helical, iyo sidoo kale in calamado shaybaarka ee uub (lupus erythematosus oo nidaamsan).

Autoantibodies ka dhanka ah DNA, kaasoo ku yaala gudahood xuduntii waxaa loo yaqaan antibodies si DNA double-ku xayiran. Sababta saxda ah ayaa laga helay dhiigga.

Waa maxay antibody ah?

siistemka difaaca aadanaha in ay soo saaraan unugyada, sidaas darteed loo yaqaan borotiinada gaar ah ula dagaalamaan dulin kala duwan, fayrasyada, fangaska, bakteeriyada, ie waxyaabaha shisheeye on heerka hidaha. Hawsha waxaa ka mid ah unugyada wax in la burburiyo wax qalaad oo uusan taaban unugyada hooyo, loo yaqaan hab is-dulqaad.

Waxaa jira xaalado marka jawaabta difaaca jirka waxaa lagu jiheeyo unugyo gaar ah iyo unugyada, ma shisheeye. Markaas waxaa jira horumarinta cudur, shalalka, iyo antibodies soo saaray dhanka ah unugyada u gaar ah iyo qaybaha ay, khubarada loo yaqaan, shalalka.

Haddii ay dhacdo of a "failure" halis ah oo difaac, kordheen heerarka autoantibodies, taas oo waa wax ku filan ku kallifto cudurka bukaanka.

Unugyada DNA double-ku xayiran - antibody ma aha mid, laakiin kala duwan oo dhan oo iyaga ka mid, taas oo ah bu'da unugga diirada DNA ah.

baaritaanka unugyada waa xasaasi ah, waayo cudurka of uub, ie, natiijo fiican ka hadli karaa xaqiijinta ee cudurka. In 70-80% ee kiisaska, bukaanka waxaa loo aqoonsaday si hufan falanqaynta this. Si kastaba ha ahaatee, ay sabab u tahay dareenka aan ku filnayn cilmi baahan yahay daryeel weyn markii reading natiijooyinka baaritaanka, sida haddii natiijadu waa negative, ma aha xaqiiqada ah in bukaanka uusan haysan uub.

assays waxay badanaa magacaabay lafaxanuunka. Laakiin jihada iyo therapist a, iyo Kelyaha, oo maqaarka waxaa loo qori karaa. Wax walba waxay ku xirnaan doontaa waxa khabiir ka hadlay bukaanka hore. shaybaarka difaaca - waa tan meesha, halkaas oo uu cilmi baaris ku saabsan antibody ah. diyaarinta gaarka ah ee falanqaynta muhiim ma aha.

Uub - nidaamsani lupus erythematosus

Uub waa cudur halis ah, shalalka oo saamayn ku qaababka xubnaha kala duwan (system of maskaxda, maqaarka, kelyaha, kala-goysyada, xididdada dhiigga iyo wadnaha). Joogitaanka isku mar ah calaamadaha in jirkooda oo dhan looma baahna. Eebbe lupus waa kuwo kala duwan, hal nin ka adkaan doonaa calaamadaha maqaarka, kan kale, tusaale ahaan - kelyaha.

Unugyada DNA hooyo double-ku xayiran caawin doona aqoonsado cudurka.

sababaha halista lupus erythematosus oo nidaamsan

• isbedel hormoon (dhalmada, uurka, caadada), kaas oo kiciyey prolactin iyo estrogen, oo uu sharaxayaa heerka sare 90% cudurada dumarka dhexdiisa.
• cabista A heer hidaha, taas oo Xaqiijiyay joogitaanka dad qaraabo ah bukaannada ka cabanaya uub heer hoose oo cudur ka mid ah nidaamka HLA iyo autoantibodies.
• Drugs - "methyldopa", "Procainamide," "Hydralazine".
• cudurka Viral ku kicin kara geeddi socodka, shalalka.
• shucaaca qoraxda (Ultraviolet rays keeni unugyada maqaarka si apoptosis DNA u dhashay, oo wuxuu noqdaa arki karo in habka difaaca jirka).

Falanqaynta antibodies in DNA double-ku xayiran waa mid aad wargelin ah.

symptomatology of uub

Tilmaamo Common ee daliilka waxaa loo yeedhi karaa qanjidhada oo barara qanjidhada, daciifnimo iyo daal, qandho, miisaan lumis, xanuun wadajir ah, iyo muruqa.

• kelyo xanuun lupus ama kelyaha (function kelyaha iyo hoos jiro triad ka mid ah calaamadaha shaybaarka).
• Arthritis iyo arthralgia, taasoo keenta caabuq iyo xanuun kala goysyada ah cumaacumaha, gacmaha, taas oo muujinaysa hoos u X-ray ah cufnaanta lafaha ku hareereysan laabatooyinku (osteoporosis periarticular) ah, si kastaba ha ahaatee, ma erosions.
• Serositis, waa caabuq xuub nabarrada oo ka mid ah wadnaha iyo sambabada (pleurisy, pericarditis).
• Photosensitivity, taasoo kallifta sii xumaanaysa ee calaamadaha. Kaddib marka uu qorraxda
• Finan, oo ay ku jiraan wajiga, finan balanbaalis ah. Unugyada DNA double-ku xayiran waxaa laga helaa loo baahdo.

• syndrome kilida - 45-65%.
• hematuria cqaadir - joogitaanka of 80% unugyada dhiigga cas ee faar kaadida.
• Proteinuria waxaa la xidhiidha khasaaraha borotiinka kaadida ee mugga ka badan 0.5 g / s weyn, i.e. 100%.
• Aad naadir in kaadida qadar weyn oo leukocytes (pyuria), gaar ahaan ay ka maqan yihiin cudurada kaadi-mareenka.

• meelo suuf-sida qaybta dambe ee isha sidoo kale sameeyay Biyana papilla ku optic.
• Joogitaanka pneumonitis ba'an lupus, dhaawac sambabada, qufaca iyo ururka qandho la dhexgalka alveolar gaashiya leh.
• Eebbe xaaladaha neuropsychiatric laga bilaabo murugada iyo dhamaanayey paroxysms epileptiform, psychosis oo arag.

Marka lagu aqoonsanayo bukaan-socodka la antibodies uub in DNA double-ku xayiran loo baahan yahay iyada oo ay gacanta ku soo noqnoqda 1-3-6-12 bilood. Waxay ku xiran tahay darnaanta cudurka. In bukaanadaan ayaa kordhisa halista waxyeellada kelyaha, maxaa yeelay, kaxeynayo antiDNK la kaxeynayo difaaca keeni kelida oo dhaawac gaaro.

falanqaynta antiDNK

Falanqaynta Tani waa lagama maarmaan,

• In la saadaaliyo guul daaweynta.
• Marka la tuhunsan yahay waxaa cudur systemic, shalalka.
• Marka natiijada antibody ENA baaritaan antibodies antinuclear wanaagsan.
• Marka calaamadaha uub joogaan.
• Marka ay joogaan looga shakisan yahay cudurka a systemic, gaar ahaan uub.
• Waayo, cudurka kala duwan ee articular syndrome ah.
• Marka natiijada baaritaanka ay noqoto antibody antinuclear wanaagsan.
• In la saadaaliyo horumarinta kelida oo dhaawac gaaro.
• Si loo xakameeyo socodka lacagta adag.

Maxaa ku dhacaya nin markii uu kiciyey unugyada DNA double-ku xayiran?

Symptomatology ee go'aaminta antiDNK

• heerkulka jirka oo kordha, qanjirada, hoos miisaanka, daal muuqataa.
• Arthritis, hurgunta kalagoysyada, muujiyey barar, xanuun, qandho ee gobolka this, casaada cudurka maqaarka iyo dhaqdhaqaaqa.
• Marka cudurka dhimirka iyo dareemayaasha atypical.
• Marka pleurisy ama pericarditis ka soo jeedo aan la garanayn.
• Marka Raynaud ee syndrome, ie, isbedel wareegsan ee midabka ah ee faraha iyo suulasha (casaan, caddaan, iyo buluug), xadgudub ku ah ay dareenka iyo xanuunka.
• cudurada kelyaha isagoo natiijada falanqaynta difaaca ama Bilowgii isbedel kaadida ah (hematuria, proteinuria).
• Marka calaamadaha maqaarka - dhagid ee maqaarka, finan, gaar ahaan ka dib markii qorrexeynayaan.
• anemia hemolytic, burburka unugyada dhiigga cas ee heerarka sare ee bilirubin in dhiiga iyo kaadida.
• Marka neutropenia, hoos u nuutrofilkaagu formula leukocyte.
• Marka Torombositobiiniya, hoos u tirada platelets ee dhiigga.

Unugyada DNA double-ku xayiran: caadiga ah

Sida caadiga ah, natiijada falanqaynta waa in ay ahaataa diidmo ah, iyo ka-fiirsashada ee 0-25 IU / ml.

Haddii jawaabtu tahay mid togan, waxaan dhihi karaa: cirrhosis biliary aasaasiga ah, uub, mononucleosis faafa; waxtarka daawaynta (uub in dembidhaafka); cagaarshowga B ee joogtada ah iyo C, Sjögren syndrome, cudurka unugyo isku qasan.

DNA Double-ku xayiran iyo antibodies (immunoglobulins IgG iyo IgM) sameeyaan adag difaaca. Isagu wuxuu ka dhigaa calaamadaha qaar ka mid ah caan ku uub.

Haddii natiijada uu yahay diidmo, la hadal oo ku saabsan daroogada lupus ama maqnaanshaha of SCR ah.

Taas oo saameyn ku natiijada baadhitaankii?

• heerka sare antiDNK la xidhiidha kelyo lupus, sii daridda cudurka ama la'aanta gacanta cudurka.
• heerka Low antiDNK la xiriira waxtarka daawaynta iyo guusha ee marxaladda of dembidhaafka cudurka.
• AntiDNK uub waa tilmaame gaar ah, laakiin waxaa laga yaabaa in ay dhacaan sidoo kale cudurada kale ee (shalalka, hepatitis C chronic iyo B).
• Haddii antiDNK lahayn, taasi meesha kama saarayso cudurka of uub.
• bukaanka Ogaanshaha antiDNK aan wax calaamado iyo shuruudaha kale ee cudurka waxa aan la daaweyn ay guushu ku dejinta cudurka of uub.

Ogeysiisyada muhiim ah

baaritaanka dhiigga unugyada DNA double-ku xayiran qabtay in lala daraasaadka soo socda:

• beta-2-microglobulin;
• Falanqaynta dhiig guud;
• antibodies antitsentromernymi;
• Falanqaynta kaadida guud;
• antibodies antigistonovymi;
  

• imtixaanada beerka (phosphatase xumadoodu, bilirubin, GGT, AST, ALT);
• Revmoproby (Aso, protein C-Waxyeelo, factor rheumatoid, heerka Kimikada erythrocyte);
• tsitrullinovomu peptide antibody (anti-CCP);
• antibodies Antinuclear (Ana). Waa autoantibodies sida ugu fiican ee bartay oo ay la socdaan factor rheumatoid. Waxaa la ogaaday in 1957, iyo waqti isku mid ah, cilmi ayaa xaqiijiyay xiriirka la uub. Sayidka unugyada DNA double-ku xayiran dallacsiiyey,

• antibodies anti-SSB iyo anti-SSA,

• anti-SCL-70 antibodies;

• antibodies anti-nRNP;

• antibodies anti-SM;
• antibodies anti-sp100.

Laba xaqiiqooyin ku saabsan antiDNK

Intaa waxaa dheer, antiDNK u muuqataa in dhiigga sabab u tahay sababahan soo socda:

• myeloma;
• Uub Faraj ogaanshaha of taas oo ah in la helo natiijo wanaagsan ee cilmi-baarista,
• cudurka pravovirusnoy;
• daroogada inutsirovannoy uub,
• HIV,
• Sjögren syndrome,
  
• cudurka cytomegalovirus,
• syndrome Sharp (cudur unugyo isku dhafan);
• mononucleosis faafa;
• arthritis rheumatoid;
• cirrhosis biliary aasaasiga ah,
• sclerosis systemic;
• fayraska cagaarshow C,
• viral hepatitis B.

Sidaa darteed, dhiigga unugyada DNA double-ku xayiran qaadan marar badan.