"Merten": analogues, tilmaamaha loo isticmaalo, dhabta ah

Medicament "Merten" - oo tayo leh Tusaale "CRESTOR" generic kooban rosuvastatin qayb sida firfircoon. Waxaa iska leh fasalka statin ee Generation IV iyo dawadu bukaan eegida 2003. Its codsiga waa macquul in ay dhacdo hypercholesterolemia iyo iyada oo loo adeegsanayo dheeraad ah ka hortagga thrombosis vascular ba'an. In xilkaan, daroogada "Merten", analogues ah oo aan tiro badan yihiin, laakiin si fiican u yaqaan, si buuxda kor ku nool in ay ujeeddada.

Form sii daayo

foomka qiyaasta Tableted "Merten" analogs daroogada ka dhiman magacyada ganacsiga diiwaan dhex-dahaarle. Inside waxa ku jira calcium rosuvastatin la excipients: laktosmonohydrat lactose, cellulose mikrokristallin, milmahayn hydroxide iyo magnesium, nooca crospovidone "A". daahan filim sheer ka kooban khamriga polyvinyl, macrogol 3350, Rusheyn kartaa iyo titanium dioxide. Waa dheeraad ah oo fudud oo aan ahayn "diyaarinta Crestor ', inkasta oo uu ogol yahay in la sii daayo tartiib ah rosuvastatin.

Waxaa qiyaasta dejinta 4: loox oo 5, 10, 20 iyo 40 mg. Waxa uu soo saaray kiniin buuxiyey oo ku yaal finan in kartoonada Mire Waqaf. Mid ka mid ah kaarka fin ka kooban 30 kiniin, kaas oo ku filan muddo bil ah ee daaweynta. Xaaladaha caafimaad oo gaar ah miyir ku isticmaasho mid ka mid ah qaadasho sheegay, taasi oo markii dambe la bedeli karaa. daawada iyo waa in lagu hayaa, qalalan, meel diiran mugdiga ah, out of carruurtu gaari karin.

Qodobada tilmaamaha loo isticmaalo

Lifaaqsan daroogada "Merten 10 mg" edbinta ku jira macluumaad ku saabsan muujinaya clinical, sababo, gumaysiga keeneysa iyo waxyeelo. Wuxuuna qeexayaa isdhexgalka daroogada suurto gal daawada, talooyinka caafimaad oo buuxda muhiim ah. qoro Drug, iyo waxa aan la heli karin oo aan qoro bukaanka ah. Sidaa darteed, billaabayso in aad qaadato analogs "Merten" ama generic "CRESTOR" iyo dhammaan daawooyinka statin, go'aamiyo jajab la egyahay dhiig iyo dhakhtar ama wadnaha la tasho.

Tilmaamayaasha

Ka hor inta isticmaalka sheyga waxaa muhiim ah in la qeexo tilmaamo iyo si aad u ogaato nooc gaar ah oo hypercholesterolemia. profile la egyahay dhiig ku siinayaa macluumaad faahfaahsan oo ku saabsan xad-shiid la egyahay iyo xad. muujinaya Target loogu isticmaalo waa sida soo socota:

• hypercholesterolemia qoys heterozygous (dhaxlo);
• hoose (genetic) polygenic nooca hypercholesterolemia IIa, lagu tilmaamay inay by Fredrickson;
• IIb dyslipidemia isku daro lagu tilmaamay inay by Fredrickson;
• hypercholesterolemia qoys Homozygous (dhaxlo);
• Atherosclerosis iyo xaaladaha sii xumayn halista wadnaha (uruureen kordhay oo kolestarool ah wadarta iyo (ama) ay jajab cufnaanta low);
• atherosclerosis, cerebrovascular iyo cudurrada wadnaha oo qayb ka ah daaweyn isku dheeli tiran (eeg sharraxaad.);
• daaweynta hypertriglyceridemi (nooca IV sida ay dyslipidemia Fredrickson) isku dhafan oo cuntada iyo jimicsiga stress.

Sharax tilmaamo ah

Salka Cadeynta ee la xiriirta xaqiiqada ah in kororka Lipoproteins low-cufnaanta jajab (LDL) in ay ku badan tahay kolestaroolka, waa ku filan. Waxaa la og yahay in darnaanta iyo heerka cudurrada wadnaha iyo cerebrovascular ku xiran tahay midda plasma hore oo kolestarool ah iyo LDL. Tani waxay abuurtaa shuruudaha loogu talagalay horumarinta atherosclerosis, formation of huurada halbowleyaasha nooca laastikada gudahood. Koritaanka tartiib ah huurada cidhiidhi Lumen ay, yaraynaysaa weelashii bandwidth sababa ischemia jirka quudin chronic.

Sida laga soo xigtay hab this waa horumarinta cudurka cerebrovascular, ischemia addinka chronic iyo cudurada wadnaha ischaemic. halbowlayaasha laastikada waxaa lagu soo bandhigay in meelaha kale ee jirka, taas oo abuuri shuruudaha loogu talagalay horumarinta obliterans atherosclerosis Addinka. Wadnaxanuun myocardial infarction iyo maskaxda yeesho sabab u ah dhaawac ee endothelium halbowlaha of huurada markabka iyo formation thrombus xiga ee. Last sii cidhiidhi Lumen ee xididdada quudinta jidhka, taas oo ay sabab u tahay qayb ka mid ah maskaxda ama myocardium dhinto.

Saamayntii isticmaalka ka hortag ah statins saddexdii jiil ee hore, iyo sidoo kale wax soo saarka si fiican, "Merten" diiwaanka, dib u eegista, iyo talooyin daaweeyayaasha si buuxda cudur daar. Adult aan calaamadaha CHD ee jira, laakiin halista ah ee ay horumarka, waxaa lagu talinayaa "Merten". Waa caqligal ah da'da 50 sano ragga iyo 60 sano loogu tala galay dumarka.

sababo

Lifaaqsan daroogada "Merten" edbinta, dhakhaatiirta dhab ah, iyo natiijooyinka baaritaano badan oo bukaan ah ayaa xaqiijiyay joogitaanka sababo buuxda oo qaraabo la taaban karo waqti. Xaaladdan oo daroogada buuxda looma isticmaali karo, halka contra ku meel gaar ah u ogolaan codsiga. sababo Absolute waa:

• Wejiga firfircoon ee cudurka beerka, cytolysis syndrome ama kordhay in ka badan saddex-laab transaminases;
• kaafi chronic ee beerka leh 9 dhibcood ku saabsan baaxadda Child-Pugh ah;
• hawlaha tilmaame renal failure raaga la ansixin kariyaatiniin ka yar 30 mL / min;
• myopathy Caafimaad ahaan la xaqiijiyey (muruqa syndrome xanuun ama rhabdomyolysis, dalalkaasi iyo bukaanka dhibaatooyin miotoksicheskim kasta);
• baahida loo qabo "Cyclosporin" diyaarinta daaweynta cudurada profile;
• Awood la'aanta in ay isticmaalaan uurka, uurka, nuujinta, carruurnimada iyo qaangaarka (18 sano);
• dareenka kor u qaybaha shaqsi, iyo (ama) dareen xaasaasi ah inay foomka qiyaasta rosuvastatin walax.

Waxa intaa dheer in kuwan, qaar ka mid ah sababo gaar ah oo si gaar ah loogu keeneysa in 40 mg "Merten" diyaarinta. Tilmaamaha loogu isticmaalo iyo analogues of tilmaamo caafimaad oo caalami ah sharxi soo socda sababo buuxda:

• oo dhan hore u soo sheegnay sababo, marka laga reebo renal failure raaga (40 mg / maalintiiba loo qaadan karaa oo kaliya la ansixin kariyaatiniin ka weyn tahay 60 mL / min);
• hypothyroidism,
• cudurada la iska dhaxlo ee unugyada muruqa;
• isticmaalka weheliso fibrates;
• tartanka Mongoloid (Reebay u yeelaan ka badan 20 mg maalintii);
• Syndrome ee ku tiirsanaanta khamriga;
• qaabilaadda hore ee rosuvastatin.

daroogada asalka ah "Crestor iyo wixii rosuvastatin (kiiskan" Merten ") analogues (micne ah) iyo generic laga yaabaa in aan loo qaadan at dose oo ah 40 mg ka hor ilaa therapy hypolipidemic aan la fuliyaa at dose hoose. Kaliya marka 20 mg dose maalin walba aan ku filnayd in ay caadi profile la egyahay ah, kaas oo la xaqiijiyay fulinta lipidogram 4 toddobaad ka dib markii laga bilaabo wakhtiga daaweynta ayaa loo baahan yahay ujeedada 40 mg maalintii. Waxaa intaa dheer, tani waa la ogolaan karo in maqnaanshaha sababo gaar ah ilaa 40 mg.

sixitaanka qiyaasta

Marka xulashada Guide mudada kacmaha ku lifaaqan daroogada "Merten" edbinta ku saabsan codsiga, ugu algorithms dhigooda caalamiga ah, horumarsan ku salaysan tilmaamo caafimaad Ahaa ESC ah, iyo sifooyinka gaarka ah ee bukaan-socodka. 5 mg ah ee daroogada waxa lagu tilmaamayaa lagu daaweyn jiray hypercholesterolemia IIa iyo IIb, nooca IV sida ay dyslipidemia Fredrickson. In ka hortaga cudurada ischaemic la xidhiidha horumarinta atherosclerosis, dose lagu taliyay sidoo kale waa 5 mg.

Qiyaasta maalin kasta of 10 mg "Merten" looga baahan yahay in daawaynta cudurada ischaemic in endothelium ee xasilinta huurada atherosclerotic iyo in la xakameeyo ballaarinta. Tani waa run for reading qiyaasta a of 20 mg, inkastoo qadarka this daroogada si habboon u isticmaalidda at qiimaha sare ee PL jajab cufnaanta hoose iyo kolestaroolka, iyo at uruuray hooseeyo jajabyada lipoprotein cufnaanta sare. qiyaasta of 40 mg loo maamulay karaa oolnimada hooseeyo 20 profile la egyahay ka dib markii mg qiimaynta. Sida laga soo xigtay talooyinka hadda Ahaa ESC, qiyaasta maalin kasta "Merten" waa la kordhin karaa ilaa 80 mg.

Features soo dhaweynta

Ugu weyn ee ilaha macluumaadka ku saabsan soo dhoweynta "Merten" daroogada - tilmaamaha loo isticmaalo. Analogs iyo generic "CRESTOR" waxaa loo isticmaalaa sida ay talooyin. Sida laga soo xigtay muuqaalada ku pharmacokinetics kaniiniyada rosuvastatin (kiiskan, "Merten") waa la aqbalay wakhti kasta oo ah maalintii. Waxay waa in loo dhan liqo, oo wax cab biyo fara badan 50-150 mg. Laakiin, sida ay ku taliyeen ee ESC iyo Ahaa ka 2014, in ay qaataan statins kasta waa in ka hor wakhtiga jiifka, iska dhego-tilmaamaha ku lifaaqan si ay u isticmaalaan.

waxyeellooyin

waxyeelo soo noqnoqda "Merten", inta jeer ee taas waa 1-10%, waa wareer, myalgia, lalabo, calool, ku shubtay calool xanuun, daal, madax xanuun. waxyeelo si kaladuwan ee soo noqnoqoshada 0.01-1%, hurdo la'aan, finan, maqaar cuncun leh, isbeddelada niyadda jihada niyadjab. saamaynta Rare (0.0001-0.01%): myositis, myopathy, rhabdomyolysis, transaminases cagaarshowga xubin-kordhinta, panreatit, anjioedema.

saamaynta aad u dhif ah, cagaarshow sabab u hepatitis sun ah, xanuun wadajir ah, hematuria, xusuus lumid, erythema exudative malignant. Waxay dhacaan wax ka yar 1 per kiiska 10 000 bukaan. Waxa kale oo suuragal ah iyo qayb ka mid ah saamaynta - sonkorta dhiigga kordhay iyo horumarinta nooca labaad ee sonkorowga. Dhibaatooyinka ay keento waa qiyaas ku tiirsan, iyo inta jeer kor u kaca ay la sii kordhaya qiyaasta. Iyada oo qiyaasood oo sii kordhaya laba jeer maalintii la kordhiyo hufnaanta by kaliya 6-10%.

Features of xidhiidhka ka adag "Merten"

Daawooyinka qaarkood waxaa lagu gartaa korodhka ama hoos u dhac ku oolnimada sumoobo halka isticmaalka diyaarinta "Merten". Analogs, xirfadlayaasha dhabta ah kuwaas oo xaqiijin habkani sidoo kale lagu gartaa isdhexgalka muhiim ah daroogada. Mamnuucay isticmaalka saameen "Merten" iyo "Cyclosporin" korodhka sababtoo ah in ka badan 7-laab-fiirsashada plasma of statin ah.

Dhammaan daawooyinka rosuvastatin kor loogu qaado saamaynta daawada xinjirowga lidka ku coumarin kasta oo u baahan la socosho INR iyo dib-u-saxo. In daaweynta HIV laguma talinayo in ay mar isticmaalaan "Merten" iyo inhibitors protease ( "LPV" iyo kuwo kale). Haddii loo baahdo, daaweynta laabjeexa nonabsorbable waa in la qaato 2 saacadood ka xaadirka ah ee codsiga of statin ka dib. Haddii daaweynta weheliso daawooyin saameeya dose saxo cytochrome ah "Merten" looma baahna.

Analogs "Merten"

In diyaarinta "Merten" analogues waa yar yihiin. farmashiyaha Total suuqa gudaha ma waxaa jira in ka badan 10 ka kooban gaarka ah. tayo The ugu horeysay oo inta badan waa "Crestor". Tani waa rosuvastatin asalka ah, kaas oo la sii daayay by AstraZeneca. "Crestor" Waxa kale oo jira tiro ka mid ah daroogada kale generic shisheeye. Tani "Rozulip", "Roxer", "Tevaskor", "Rozart", "Rozukard". Daroogooyinka sida "AKORT" iyo "Rosuvastatin Canon", ku dhowaad isku mid ah in diyaarinta Halabuurka "Merten" - dhigooda Ruush. Waxay soo saaraan shirkadaha dawooyinka ee qoyska.

Review of diyaarinta "Merten"

Bukaan-qaadashada daawooyinka la egyahay-hoos, ma caddayn karo ama diidaan waxtarka daroogada gaar ah. Si kastaba ha ahaatee, ku salaysan natiijooyinka profile la egyahay, khabiir ku qiyaasay, waxaad xukumi kara tayada daawada. "Merten" 3 bilood at dose a-daweynta normalizes profile ku egyahay ee serum dhiigga. saamayn A caafimaad oo loo arki karaa 4-6 toddobaad gudahooda. Sidaas darteed, ay sabab u tahay tsitohromovogo-shiid cagaarshowga ka itaalka daran, waxa ay leedahay qadar yar oo ah isdhexgalka daawada.

Bukaan-socodka ah "Mertenile" jawaabtaadu mid fiican, sababtoo ah dhacdooyinka hooseeyo of dhibaato. Isticmaalka qolof fudud oo kiniin yaraynaysaa halista ah ee saamayn gastrotoksicheskogo maxaliga ah. Ku saabsan sida in ay ka jawaabaan, bukaanka, lallabo iyo dyspepsia dhacaan wax badan ka yar inta badan ka badan in ay dhacdo statin hore ( "dawo" iyo "pravastatin"). Waxaa intaa dheer, sida ay talooyinka wadnaha, on waxtarka "Merten" Insignificance liita "Crestor". analogues kale ee ka kooban leeyihiin qiimo la mid ah daweynta.