"Esomeprazole": tilmaamaha loo isticmaalo, dhigooda dhabta ah

"Esomeprazole" - daroogada ah in iska leh Organotropona daawooyinka caloosha iyo mindhicirka. daroogada waxay leedahay tallaabo antiulcer iyo waa inhibitor bamka proton ah.

Halabuurka The, foomka sii daayo "esomeprazole" daroogada

Daawada waxaa laga heli karaa qaab kiniin la qiyaasta ah ee 20 iyo 40 mg ah esomeprazole firfircoon, iyo sidoo kale foomka budada ah loogu talagalay xal la isku duro (40 weelka mg) ee. kiniinada, kala diridda oo meel xiidmaha.

tallaabo pharmacological "esomeprazole" daroogada

Waa maxay daawada "esomeprazole"? Tilmaamaha loogu isticmaalo muujinaysaa in wakiilka antiulcer this, kaas oo, isagoo saldhig daciif ah, uu helo foomka firfircoon ka dib markii uu qofku cuno. "Esomeprazole" hakiyo eulayska H ⁺ -K ⁺ -ATPase dhaqdhaqaaqa, iyo dheecaan of aashito (kiciyaa, asalka). tallaabada lagama maarmaanka dhacdaa saacad gudahood ka dib marka uu qofku cuno ee daroogada. Marka la helo "esomeprazole" dhigay maalin kasta, muddo shan maalmood ah, qiyaas la ogolyahay maalin kasta - 20 mg ka dib markii kicinta by pentagastrin heerka ugu sareeya ee Aashito waa la dhimay si xooga (qiyaastii 90%).

Pharmacokinetics

"Esomeprazole" tilmaamaha loogu isticmaalo waa sida daroogada taas, cabaar jirka gudihiisa, si degdeg ah oo si fiican u nuugo, xidhana borotiinka dhowaad 100% (97%). bioavailability wuxuu ku kordhiyay la noqnoqoshada isticmaalka nacasta ka 64 si ay u 89%. medicament wuxuu qaadanayaa qaab metabolites oo raaca horrayn kaadida, qayb yar oo dhanba la joogo in saxaradu ku.

Tilmaamayaasha "esomeprazole" diyaarinta

analogues "Esomeprazole" loo isticmaalo ee bukaanka qaba cudurka reflux gastroesophageal daaweynta iyo ka hortaga labakaclaynta. aalad loo isticmaalo in lagu daaweeyo boogaha caloosha ama malawadka, ka hortagga cudurka timi sabab u NSAIDs.

Daawada loo isticmaalo in boog ulcer markii ay saameeyeen malawadka ama caloosha. Waxaa lagu saleyn karaa bukaanka lagu daaweyn esophagitis, inta lagu guda jiro ka hortagga labakaclaynta daba dheeraaday. codsiga wadajirka ah ee la ogolaan la yahay "esomeprazole" daawooyin lid ku ah bakteeriyada. Kiniiniyada iyo duro ee therapy isku dhafan ay dhacdo in this ogolaan baabbi'in Pylori Helicobacter.

Sababo in la helo "esomeprazole" daroogada

Sababo ka mid ah da'da ka yar laba iyo toban sannadood, diidmo in esomeprazole, xilliga naas-nuujinta. Cawaaqib xumada daaweynta daawada aan la aasaasay inta aad uurka leedahay.

Isticmaalka daroogada

Daawada waxaa loo isticmaalaa in dose maalinle ah oo 20-40 mg. Muddada daaweynta waxaa ka go'an muujinaya habdhaqan iyo soo dhaweynta medicament hufnaan "esomeprazole". Kiniiniyada iyo xal la barwaaqaysan adag at la'aan kelyaha la isticmaalayo qiyaasta ugu badnaan 20 mg.

esophagitis reflux Erosive daweeyey afar isbuuc dose maalinle ah oo 40 mg. Inta lagu jiro ka hortagga daba dheeraaday ee ku xoogeystay ku salaysan soo dhaweynta ka dhigan tahay bukaanka ah oo esophagitis la daaweyn, qiyaasta maalinlaha ah ayaa lagu wadaa in kala duwan ee 20 mg.

In daaweynta esophagitis reflux, loogu talagalay wax ka qabashada calaamadaha cudurka ku lammaan, qaadashada 20 mg ah ee daawada "esomeprazole". Diyaargaraw qaab kiniin oo ah budada loo isticmaalaa in lagu dilo H. Pylori, marka uu jiro xiriirka ay la boog dyspepsia, in therapy isku dhafan - "esomeprazole" (20 mg), "Clarithromycin (500 mg)," amoxycillin "(1 g). daawo All qaataa laba jeer maalintii.

boogaha caloosha sababa NSAIDs, waxaa lagu talinayaa in lagu daweeyo 20 mg "esomeprazole" maalin kasta. Qiyaasta la doonayo waxaa mar walba loo xilsaaray in ay dhakhtar la tixgelinayo caafimaadka ee bukaan-socodka, cudurka, darnaanta ay dabcan, iyo arrimo kale oo muhiim ah.

Waxyeellada "esomeprazole" daroogada

Bukaanka qaadato daawooyinkan muddo dheer, waa ka badan u nugul formation of fiix jilacsan ee caloosha ka badan bukaanka kale. The daliilka ugu badan loo kasin ee jirka intii lagu daaweyn waxay ka dhigan tahay "esomeprazole" edbinta ku saabsan codsigaaga u qoondaysay madax xanuun iyo qaar ka mid ah falcelin xun ka mareenka caloosha iyo mindhicirka, sida: caloosha oo, yaaqyaaqsi, shuban, lallabo, matag, jiritaanka xanuun caloosha. By waxyeelo ka yar waxaa ka mid ah qalajiyo xabka ee afka, dawakhaad, urtikaria, cuncun, dermatitis ah. Dareen-celinta kale waa u suurtoobaan, sidaas daaweynta waa in la sameeyaa si adag iyada oo ay kormeerayaan dhakhtar takhasus u leh.

Iska badinta waxaa ku weheliyay tabar guud, sii kordhaya dhacdooyinka of waxyeelo, oo ay ku jiraan oo ku saabsan qayb ka mid ah marinka dheef shiidka. Xaaladaha noocaas ah, daaweynta waxaa lagu sameeyaa by baabi'inta calaamadaha xad dhaafka ah iyo therapy dayactirka. Dialysis ayaa ku dhowaad saamayn doonayo ma, jirto daawo lahayn.

ganaaxyada

Haweenka uurka leh analogs "esomeprazole" maamulay si taxadar leh u daran. Daaweynta inta aad uurka leedahay waa in la kormeero dhakhtar. daroogada la qoray in haweenka uurka leh oo keliya in Xaaladaha ay saameynta wanaagsan ee jirkooda si weyn u badan tahay dhib ka iman kara in ilmaha aan weli dhalan. xogta lagu kalsoonaan karo oo ku saabsan saamaynta daroogada on embriyaha weli weeye, intii suurtogal ah waa in ay ka fogaadaan la qaataa dawo this. Isticmaalka daroogada "esomeprazole" marka naas-nuujinta waa ka mamnuuc.

Marka xadgudubyada beerka iyo aad u dose go'an tahay mid halis ku ah caafimaadka (haddii xadgudubyada kuwanu waa halis ah).

calaamadaha bukaanka Marka waxaa lagu calaamadeeyay signal, sida hematemesis, dysphagia, lalabo, hoos u weyn ee miisaanka jidhka inta lagu jiro muddada daawaynta "esomeprazole" si uu u baabi'iyo ama boog ay sabab u tahay qaadashada daroogada iyadoo ay wada joogaan cudurka looga shakisan yahay, kansar waa in la tirtiro. Si loo garto nooca malignant of burooyinka lagama maarmaan ah in daraasad ah.

Bukaanka qaba la'aan ah sucrase-isomaltase, dhaxlo qof dulqaad fructose Reebay in uu magacaabo micne ah "esomeprazole".

Dhexgalka "esomeprazole" daawooyin kale

Iyadoo la isticmaalayo isku mar daroogada la "Citalopram", "clomipramine", "imipramine" potentiation suurto galka ah ee wakiilada, kuwaas oo, horumar oo ah walaxda firfircoon ee dhiigga. Marka lala isticmaalaa "esomeprazole" hoos hufnaan "ketokonazol" "Itraconazole" dara ay nuugista.

Marka isku ah "esomeprazole" with "ATV" ayaa hoos u dhac weyn oo gaadhista ee daroogada this. "Esomeprazole" edbinta hawlgalka laguma talinayo in ay mar isticmaalaan la "phenytoin", "clomipramine", "imipramine" iyo daawooyin sida "Citalopram", "Diazepam", "Nelfinavir" iyo "Atazanavir". Heerka daawooyinkan waa u awoodin inay kacaan in dhiigga, sidaas darteed waxaa laga yaabaa in la jecel yahay in hoos u qaadasho ay. isticmaalka saameen of «esomeprazole" oo macnaheedu yahay "clarithromycin" keenaysaa in isbedel la taaban karo ku-gaadhista "esomeprazole" dhacdaa kordhinaysaa la xidhiidha Iscelin shiid of daroogada. Waa kuwee waa in si taxadar leh loo arkaa instrukiyu inay daroogada iyo la tasho dhakhtar takhasus u leh.

Qiimaha daroogada, dib u ah oo ku saabsan "esomeprazole" daroogada

Daawada inta badan ka heleen qaab kiniin ah. Farmasiyada "esomeprazole" waxaa laga heli karaa magacyada ganacsiga "Nexium" iyo "Emanera". Marka aad iibsato daroogo "esomeprazole" qiimaha ay ku xidhan tahay qiyaasta oo ah walaxda firfircoon ee ay ka kooban. Qiimaha daroogada ee qiyaasta a of 20 mg ( "Emanera") wuxuu ku saabsan yahay 500 rubles. 28 kiniin oo waxaa lagu go'aamiyaa soo saaraha. Dawooyinka la qiyaas ah 40 mg ah qayb firfircoon ( "Nexium" 28 xabbo oo kiniin) waxaa laga iibsan karaa 3000 rubles.

"Esomeprazole" ayaa dib u eegista ay inta badan wanaagsan. Waxay xusay hantida daroogada si uu xakameeyo dheecaan acid, asalka iyo dhiiri labadaba. daroogada ayaa muujiyey oggolyahay sare ee daaweynta ee xaaladaha u dhigma tilmaamo cad edbinta. Inta lagu jiro daaweynta, taas macnaheedu waa waxaa jira siday suuragal u yar oo waxyeelo. Ma aha qof kasta si fudud u awoodaa inuu ku helo daroogada ah ee farmashiyaha, bukaanada qaar ka mid ah kuwaas oo helay "esomeprazole", qiimaha ay u muuqataa sare.

Kuwa qaaday daawada uu dhakhtarku soo qoro ka dib qeexid sax ah oo ka mid ah cudurka iyo dose lagu taliyay, calaamadee horumar weyn oo caafimaad. Sida dib u eegista ah, "Nexium" ka mid ah bukaanka badan "Emanera" dheeraad ah oo caan ah. Marka "Nexium" gastric bixisaa muuqaalka kore ee natiijada la rabay ka dib markii ku saabsan hal bil ka dib markii bilow ah therapy. Hagaajinta xaaladda dhici karaan 1.5 daawaynta todobaadyo. Dhibaatooyinka ay keento waa dhif iyo naadir. Drug "Nexium" wax ku ool ah, waxay ka caawisaa baabi'inta ee xaaladaha ku xusan tilmaamaha. In natiijada ay ahayd mid wanaagsan, waxaa lagama maarmaan ah si ay u dhamaystiraan koorsada oo idil oo si buuxda u hoggaansamaan talooyinka dhakhtarka.

Analogs "esomeprazole"

The qaab lagu kala sooci karaa laga bilaabo analogues daroogada:

• "Omeprazole" - sidoo kale loo yaqaan "Losek", "Omez", "Ultop";
• "Rabeprazole" - diyaarinta loo yaqaan hoos magacyada "Ontaym", "Zulbeks", "Noflyuks" "Pariet", "Hayrabezol";
• "Pantoprazole" ( "Sanpraz", "Kontrolok", "Nolpaza");
• "Lansoprazole" ( "Lanza", "Lanzoptol").

daroogada Kuwaas oo dhan saamaynta la mid ah, laakiin waxay ku kala duwan ka soo midba midka kale in ay qiimaha.

U dhigma "esomeprazole" iyo "Omeprazole". Kala duwan oo dawooyinkan yihiin cad. "Esomeprazole" waa isomer ah "omeprazole". diyaarinta Tani, laga bilaabo xogta suugaanta caafimaad, uu leeyahay faa'iido badan, laakiin tallaabo la mid ah medicaments. "Omeprazole" waa qiimaha gundhigga daroogada in tiro badan oo ah waxyeelo. Haddii aan ka fiirsan guryaha ah "esomeprazole", daroogada la soo bandhigay sida version la hagaajiyey ee "omeprazole", qiimaha taas oo soo jiidatay dad badan oo buka. Si kastaba ha ahaatee, "esomeprazole" yar tahay in ay keeni dareen diidmo oo aan la rabin, si ay iibka waxaa loo arkaa more faa'iido badan iibsato "Omeprazole".

"Rabeprazole" iyo "esomeprazole" leedahay Halabuurka kiimikada la mid ah, waxay daweeyo cudurka la mid ah. Laakiin khubarada aaminsan yihiin in cudurrada qaar ka mid ah, sida cudurka reflux gastroesophageal, "Rabeprazole" tiraa wax ku ool ah ka badan, waxaa ka saaraysaa calaamado fiican, waxa ay gacan ka geysaneysaa soo kabashada degdeg ah shuqullada hunguriga. la'aanta ah ee saamayn togan ee daaweynta ee "esomeprazole" waxaa laga yaabaa in la xidhiidha astaamaha gaarka ah ee u shaqeeyo.

Haddii loo baahdo, dooran analoogga ah waa in la tasho dhakhtar. Ula dhaqan dheeraad ah u digtoon in ay caafimaad, iyo mari kormeerka in waqti, ka dibna dib u soo kabashada dhakhso noqon doono iyo in aad ka fogaato doonaa dhibaatooyin badan.