"Endoxane": tilmaamaha loo isticmaalo, dhigooda dhabta ah, soo saaraha

Drug "endoxane" waxa loola jeedaa koox ka mid ah wakiilada anti-buro. Iyadoo ku xiran qaab daayo waxa loo qaadan karaa afka ama parenterally. Waa maxay nooca daroogada magacaabi iyo waxa qiyaasta, furfuraya dhakhtar oo kaliya ku salaysan xaaladaha dhabta ah ee xaaladda bukaanka.

The Halabuurka iyo sifooyinka daroogada

The qayb weyn ee firfircoon ee daroogada tilmaamaha "endoxane" loo isticmaalo waxaa loola jeedaa cyclophosphamide. Mid ka mid ah kiniin ka kooban 50 mg waxaa ka mid ah. Daawada waxaa loola jeedaa koox ka mid ah daroogada antitumor iyo waa kiniin ah biconcave la socoto baqshad cad oo muhimka ah ee cado isla. qaybaha Sida dheeraad ah wax soo saarka dawooyinka firfircoon oo ka kooban carbonate calcium iyo phosphate hydrogen, sodium karamellozu, glycerol, gelatin, lactose, galleyda, macrogol, milmahayn magnesium, polysorbate, sucrose, Rusheyn kartaa, silica iyo titanium.

Waa maxay Farmashiiste ee daroogada?

The walax daroogada firfircoon ugu weyn, kuwaas oo cyclophosphamide, alkylating oo uu leeyahay saamayn cytostatic. By ay dabiicadda, waxaa ku dhow yahay inuu gaaska iniin khardal, nitrogen isagoo ay analoogga.

hab ay of tallaabo of cyclophosphamide ku salaysan formation of crosslinks dhexeeya taagoo DNA iyo RNA iyo hay'adaha Avv borotiinka xakamaynayaan.

The pharmacokinetics daroogada

The qayb firfircoon "endoxane" muhiimsan ee daroogada waxa uu shahaadada gebi ahaanba absorbability ka mareenka caloosha iyo mindhicirka. Its fiirsashada in dhiig ka dib markii maamulka afka iyo xididka waa isku mid. Dheef-Cyclophosphamide dhacdaa ugu horrayn beerka, halkaas oo sarkhaansan yihiin hab oxidase microsomal waa formation of metabolites alkylating firfircoon. Qaar ka mid ah iyaga ka mid ah waxaa lagu beddelay foomamka aan firfircoonayn, koox kale oo ka dhaqaaqaa unugyada, halkaas oo tallaabo ka enzymatic of phosphatases beddelaa walxaha la guryaha cytotoxic.

Degree ee ku qabanaya foomka asalka ah ee daroogada la borotiinka dhiigga waa mid laga samri oo waa 12-14%. Si kastaba ha ahaatee, isla tilmaame of metabolites horay u dhigmaa 60%.

cyclophosphamide soo saaray Digo kelyaha inta badan ee foomka of metabolites. Qiyaastii 5-25% ka mid ah daroogada waxaa raaca in Qaabkiisu in ay kaadida iyo bile.

Halbeegga T1 / 2 ee daroogada uyeelaysaan 7 saacadood ee dadka waaweyn iyo 4 saacadood ee carruurta.

In waxa dose in ay qaataan daawada?

Drug "endoxane" kiniin afka laga qaato cunto ama nus saac ka hor cuntada cunto ka dib, 2 saacadood ka dib.

Sababo la xaqiiqada ah in wax soo saarka dawooyinka ku jira tiro badan oo ah daawada kiimikada, hab doorashada ee maamulka iyo qiyaasta dhakhtarka loo arkaa gaar ah.

"Endoxan" - kiniin - hage ku talinaysaa qiyaasta 1-3 mg / kg miisaanka ku jirka ah maalin kasta, taas oo laga yaabaa in ka 50 ilaa 200 mg cyclophosphamide 24 saacadood. Muddada aad daawada waa 2-3 toddobaad.

Haddii daroogada la isku qaato daawooyin kale in ay leeyihiin guryaha anti-buro, qiyaasta oo dhan xubno ka therapy Oo Qaliin saxo.

waxaa jiri kara badinta?

Joogitaanka daawo gaar ah ee diyaarinta "endoxane tilmaamaha 'si loogu isticmaalo ma aha xaqiijiyay. In case of aad iyo aad u dose la doonayo lagu talinayaa in therapy dayactirka sida daaweynta ku haboon cudurrada faafa, astaamaha u-barashada cardiotoxicity iyo tirtiridda myelosuppression.

Sida daawo la isku daro daawooyin kale?

Haddii bukaanka qaadataa hab ka xanaajin qayilo microsomal beerka, ka dibna daaweynta weheliso daroogada "endoxan" edbinta muujinaysaa Avv sii kordhaya ee metabolites hawlaha alkylating, hoos u bar-nolosha ee cyclophosphamide iyo kordhiso hufnaan.

daroogada Tani hakiyo dhaqdhaqaaqa cholinesterase iyo cocaine dariiqa dheefshiidka, kordhinta ay sumoobo, iyo kordhisaa tayada shaqo ee suxamethonium.

Haddii "endoxane" waxaa lala isticmaalaa "Allopurinol" in ay jiraan waxaa kordhay saamaynta taban ee ay ku dhuuxa lafta.

In the case of daaweyn isku mar la cyclophosphamide, colchicine, probenecid, dhakhtarka sulfinpyrazone badanaa canaanto qiyaasta daawooyinka anti-turqo. Tani waxay la xidhiidhaa halis dheeraad ah nephropathy in a codsiga wadajirka ah "endoxane" daawooyin uricosuric.

Cyclophosphamide yaraynaysaa arrimo Avv beerka, ayaa ka mas'uul ah xinjirowga dhiigga iyo wax soo saarka dhiig xinjirowga sameeya, si kastaba ha ahaatee, inta daaweynta daawada xinjirowga lidka hoos u dhaqdhaqaaqa doonana.

Bukaan-qaadashada "endoxan" Buuggan daroogada edbinta ku talinaysaa cunto marka laga reebo juice bambeelmo ah, tan iyo markii ay ka kooban qaybaha in xad-oolnimada hawlgelinta iyo qayb weyn ee firfircoon ee medicament ah.

Markii wada-maamusho la cyclophosphamide "Doxorubicin" ama "daunorubicin" waxaa maqalka saamaynta cardiotoxic ee daawooyinkan.

Isku dhafan oo immunosuppressants kale, sida "azathioprine" "takrolimus", "Chlorambucil", "SSC", "Merkapturin" keenaysaa in la kordhiyo dhacdo ee cudurada sare iyo nooca burada.

In the case of si wadajir ah loo isticmaalo "endoxane" iyo "Lovastina" bukaanka qaba wadne laga yaabaa in halista ah ee rhabdomyolysis iyo kelyaha qaab daran.

Haddii daaweynta la cyclophosphamide weheliso mielosupressantami ama daaweynta shucaaca, waxaa suurtagal ah in ay helaan ugneeniya function dhuuxa lafaha.

soo dhaweynta wadajira "endoxan" la-dose sare cytarabine inta lagu guda jiro manipulations diyaarinta si dhuuxa lafta kordhiyaa dhacdooyinka cardiomyopathy dilaa.

Sidee daroogada this on function taranka?

Drug "endoxane" Kurtumm bukaanka xaqiijisid, cadhaysiinina kartaa ma dhalaysnimo in bukaanka ee labada jinsiba, kaas oo noqon kara karin.

Xaaladaha intooda badan, haweenka amenorrhea dhacdaa, laakiin joogto caadada caadi ahaan ka soo kaban ah dhawr bilood gudahood daaweynta la cyclophosphamide ka dib. Haddii therapy waxaa fuliyay in gabdhaha prepubertal, leexashooyinkaasi ee horumarinta daliilka galmada sare ayaa lagu arkay. Caadada ahaa mid caadi ah, bacriminta lumay.

In daaweynta daroogada lab "endoxane" edbinta muujinaysaa in xaaladaha qaarkood ayaa la soo sheegay azoospermia ama oligospermia. Tan waxa u sabab wax soo saarka kor u gonadotropins heer ah loo sii daayo testosterone. heerka libido iyo awoodba in rag aan la dhimay. Haddii daaweynta la cyclophosphamide soo saaray wiilasha prepubertal, daliilka galmada sare obazovanie ayaa si caadi ah u dhacay. Si kastaba ha ahaatee, kiisas of azoospermia, oligospermia iyo horumarinta gonadotropins ayaa lagu xusay. Waxa kale oo dhici kara atrophy Testicular. Waxaa xusid mudan in azoospermia waa karo, inkasta oo ay soo kabashada ee hawlaha ku dhici karaa dhawr sano ka dib dhamaadka daaweyn gudahood.

Waa maxay saamaynta dhinaca of daroogada?

Qaadashada daawada "tilmaamaha endoxane 'loo isticmaalo waxaa la xaqiijiyay, waxaa laga yaabaa inay sababaan xanuunada qaar ka mid ah nidaamka hemopoietic:

• Leukopenia, neutropenia - marar badan.
• In ka yar caadiga ah waa dhiig iyo Torombositobiiniya.

1-2 toddobaad tan iyo bilowgii Daawaynta ka dib, bukaan-socodka tilmaamay hoos ugu badan ee leukocytes iyo platelets ee dhiigga. xuduudaheedu waa la soo celiyay si caadi ah 7-10 maalmood ee ugu dambaysta ah ee therapy gudahood.

In daaweynta la cyclophosphamide keeni karaan dhinac ee mareenka caloosha iyo mindhicirka,

• Lalabo iyo matag.
• Anorekisya.
• Stomatitis.
• Xanuun gobolka caloosha.
• khaladaad saxarada.
• Cagaarshow.
• colitis dhiigbaxa.

Marar dhif ah ayaa dhici cillad beerka ee la xidhiidha waxqabadka siyaaday of falgalka iyo heerarka bilirubin kici. Waxay jeelyihiin in kooxo badan oo bukaanka qaba dhiig yari aplastic iyo hesho Qiyaas sare "endoxane" ama lagu daro busulfan, ayaa sheegay in endoflebit xididdada cagaarshowga. Tani waxay ifafaale dhici karaa 1-3 toddobaad ka dib markii dhuuxa lafta waxaana la muujiyey in kor u kac wayn ee mass jirka, ascites, hepatomegaly iyo hyperbilirubinemia, encephalopathy cagaarshowga.

Ka hor inta daroogada waxay keeni kartaa falcelin aan loo baahnayn la maqaarka:

• alopecia karo.
• Finan.
• midabka jirka ah ee maqaarka iyo ciddiyaha.

Waxa kale oo la keeni kara xadgudub ku ah nidaamka kaadida ee daaweynta ee daroogada "endoxane". Tilmaamaha, dib u eegista ah dhakhaatiirta iyo bukaanka si ay u muujiyaan gobolo kala duwan:

• Cystitis weheliyaan kaadi fibrosis (ama waxa aan).
• urethritis dhiigbaxa.
• ifafaale Necrotic tubule ilaa uu ka dhinto.

In kaadida, bukaanka waxaa lagu ogaan karaa iyada oo epithelium kaadi haysta kaadida. Haddii foomka of dhiigbaxa cystitis culus, joojin qaadashada daawada. ka hortagga ugu wanaagsan ee xaaladan waa daawada "Mesna". Haddii qiyaasta "endoxan" kordhay, horumarin karaan cillad kelyaha sida nephropathy iyo giperurekemii.

Haddii bukaanka uu shahaadada daran ee Baabi'id, ka dibna lagu daaweyn jiray cyclophosphamide la kulmi karaan cudurada daran.

Sidoo kale qaadi karaan dhibaatooyinka soo socda:

• Cardiotoxicity (dose sare), heerka ba'an ee wadnaha oo shaqadiisa gaba.
• cystic sambabada, dabeecadda interstitial.
• Oo khash-spermatogenesis iyo oogenesis, karo iyo dhalaysnimo karin.
• Horumarinta ee neoplasms malignant sare sida kansarka kaadi haysta, mieloproliferatsiya iyo lymphoproliferation.
• Xasaasiyadda sida finan, cuncun, urtikaria, mararka qaarkood qaab dareen anaphylactic.
• bogsashada dhaawaca saboolka ah.
• barrar wajiga, dhidid, madax xanuun.

Jiritaanka saameyn khatar ah ka qaadato daawada waxaa had iyo jeer kicisaa su'aasha ku saabsan faa'iidooyinka ay suurto gal ka dhan ah halista suuragal ah in bukaanka shaqsi.

Waa kuwee cudurada qori daroogada this?

Kiniiniga "endoxan" Waxaa laga yaabaa in lagu meeleeyo bukaanka haddii waxa uu leeyahay cudurada soo socda:

• cudurka Hodgkin.
• myeloma.
• Kansarka naasaha.
• lymphoma Lymphoblastic qaab daran ama joogtada.
• Non-Hodgkin ee nooca lymphoma.
• Retinoblastoma.
• Neuroblastoma.
• Mycosis qof gribkovidnogo.

Waxay muujinaysaa dhoweynayo codsiga ee therapy ah anticancer adag ku lifaaqan daroogada "endoxane" edbinta. saaraha waxay ku talinaysaa in ka mid ah in lagu daaweeyo kansarka afka ilmo-galeenka iyo kansarka kaadiheysta, kansarka sanbabada iyo kansarka qanjidhka, sarcomas iyo reticulosarcoma, cudurada Ewing iyo Wilms.

cyclophosphamide ku saleysan daroogada waxaa loo isticmaali karaa sida cudurada immunosuppressant horusocod ah, shalalka sida, psoriatic iyo rheumatoid arthritis, anemia haemolytic, cudurada collagen, nephrotic syndrome, iyo sidoo kale in ay ka fogaadaan diidmada jab.

Marka daroogada waa u?

medicament The "endoxan" waxay leedahay sababo miisaan, oo ay ku jiraan:

• Uurka iyo nuujinta.
• Cystitis.
• Infections foomka firfircoon.
• Ku xadgudubka shaqaynaya dhuuxa lafta foomka loogu dhawaaqaa.
• Joogitaanka diidmo in walxaha daroogada aasaasiga ah iyo dheeraad ah.
• haynta kaadida.

dhakhaatiirta daryeel gaar ah kuu qori daroogada ee cudurrada wadnaha, kelyaha iyo beerka, daran, turqo, adrenalectomy, joogitaanka hababka dhexgalka dhuuxa lafta, nefrourolitiaze.

hanuun gaarka ah ee daaweynta ee

Inta lagu guda jiro qofku ku xiran "endoxan" si ay dhiig u qasabka gacanta (neutrophils iyo dhiig xinjirowga) iyo kaadida (joogitaanka unugyada dhiigga cas) ee bukaanka ah.

waxaa lagu talinayaa in la joojiyo daawada "endoxane" waxaa loola jeedaa xaaladaha qaarkood. Tilmaamo ku saabsan isticmaalka kiniinka lagu talinayaa in sidaas la sameeyo oo hoos shuruudaha soo socda:

• Tilmaamayaasha Astaanta cystitis.
• Qaadista fiirsashada of leukocytes iyo platelets in qiimaha muhiimka ah.
• Dhacdo cudurka (dose saxo waxaa suurtagal ah).

Haddii "endoxane" waxaa loo isticmaalaa in dose sare, bukaanka waxaa soo qoray daawo, "Meena" ka hortaga nooc cystitis dhiigbaxa.

In daaweynta la daroogada this waa in ay iska ilaaliyaan la cabbo khamriga iyo la isticmaalayo habab lagu kalsoonaan karo ee ka hortagga uurka.

Haddii bukaanka waxa lagu qoray "endoxan" muddo 10 maalmood ah qalitaanka la suuxinta guud ka dib, suuxdinta lagu wargaliyo oo arrintan ku saabsan.

Ka dib markii adrenalectomy sameeyaa a dose sixitaanka "endoxane" iyo corticosteroids daroogooyinka kale.

analogues daroogada

Haddii ay jiraan sababo dhab ah iyo khataraha, ka dibna u bixiyey in la siiyo qaadashada daawada "endoxane" edbinta. Analogs loo qori karaa dhakhtar sida kale oo ku habboon. Ka mid ah iyaga,

• "Ledoksin".
• "Cyclophosphamide".
• "Cytoxan."
• "Cyclophosphamide - Teva".
• "Cyclophosphamide -Lens".
• "Endoxane - Astana".

Macluumaadkan waxaa version la fududeeyey of tilmaamaha si "endoxane" daroogada. Ujeedada daroogada taas waxaa loo sameeyey keliya uu dhakhtarka xaadirka ah.