Daroogada Anti-estrogen: description, codsiga

Estrogen-blockers waa kiimiko ah in loo joojiyo tallaabada of estrogen. daroogada Antiestrogen loo isticmaalo in lagu daaweeyo cudurro kala duwan. Waxaa si weyn loo loo isticmaalo daweynta kansarka naasaha geedi socodka in ay la xakameeyo koritaanka buro ama ka hortagga labakaclaynta. Sida kiiska daawooyin kale oo la macaamilaan hormoonnada ah ee jirka ku, daawooyinkan waa in la isticmaalaa iyada oo ay kormeerayaan caafimaad.

Faa'iidooyinka iyo waxyeellooyinka ee estrogen

Estrogen, ama hormone ah steroid dhexsameeysmo horrayn by ugxan. Wuxuu saameeyaa tiro ka mid ah geedi socodka ka mid ah jidhka. Haweenka ku jira da'da dhalmada ay leeyihiin heerka ugu sareeya ee hormone dabiiciga ah. qadar xad-dhaaf ah, si kastaba ha ahaatee, waxay keeni kartaa syndrome loo yaqaan hyperestrogenia. Cudurka Tani waxay keeni kartaa in nidaamka kansarka naasaha iyo gooba cadeymaha kansarka. daroogada Anti-estrogen iyo blockers estrogen iyo inhibitors aromatase hagaaji kartaa wax walba. daawooyinkan, si kastaba ha ahaatee, waxay leeyihiin saamayn togan iyo kuwa taban ee ragga iyo dumarka.

Noocyada estrogen-blockers iyo isticmaalkooda

Waxaa jira tiro ka mid ah noocyada kala duwan ee estrogen-blockers. inhibitors aromatase dhab xannibi soo saarka ee estrogen. modulators Selective estrogen receptor, sida "tamoxin" "Clomiphene", loogu talagalay in lagu xiri receptors estrogen, iyo dhaqmaan waayo, noocyo kala duwan oo dhar kala duwan. Antiestrogens sidoo kale xannibi receptors estrogen.

Antiestrogens hortago beddelidda ee testosterone si estradiol oo hormoonnada estrogen joojiyaan in ay ku shaqeeyaan ama hor istaagay.

In daaweynta kansarka, daawooyinka, kuwaas oo waxaa loo isticmaalaa in hoos u dhigi horumarinta burooyinka. Xaaladdan oo kale, modulators receptor estrogen la xushay la bartilmaameedsan karaan si ay receptors estrogen gaar ah. Blockers, oo ay ku jiraan "Clomiphene" waxaa sidoo kale mararka qaar loo isticmaalaa in lagu daaweeyo dhalmo la'aan, waxay kaa caawin kartaa qaar ka mid ah haweenka ay ku adag tahay uur. Daawooyinkan waxaa sidoo kale loo isticmaalaa by rugaha qaar ka mid ah in lagu daweeyo carruurta la baaluqo raagay ilaa ay jirka ku filan.

Ka mid ah bodybuilders ka dhigeen isticmaalka estrogen-blockers sababta oo ah saamaynta estrogenic of heer sare ah testosterone ee jirka. Testosterone waa maamaan ah estrogen ah, inhibitors aromatase waxaa loo isticmaali karaa si ay u joojiyaan formation of muruqa xad-dhaaf ah mass ee estrogen, dayactirka heerka hoose ee jirka. Falkaan ayaa soo jiitay dad badan, gaar ahaan marka daawooyinka anti-estrogen waxaa ugu horayn loo isticmaalo ujeeddooyin isku qurxiyo. Xaaladdan oo kale, qof ayaa isticmaalaya kiniin iyo supplements nafaqo la'aan kormeer caafimaad.

waxyeellooyin

Waxaa jira waxyeellooyin ah daawooyinka anti-estrogen. Waxay keeni kartaa wareer, madax xanuun, dhidid, dareenka gubashada ah iyo wareer. Kaliya endocrinologist loo ogaado waxaa laga yaabaa in qiyaasta haboon bukaanka ah ku xiran tahay xaaladda, oo marinka la aqbali karo waxyeelo. endocrinologist ayaa sidoo kale qori karaa baaritaan dhiig oo joogto ah heerarka hormone marka qiimaynta caafimaadka guud ee bukaanka si loo xaqiijiyo in isticmaalka anti-estrogens waa ammaan iyo functional bukaanka.

nin daaweynta

Iyadoo da'da, lab heerarka testosterone daadiyaa. Si kastaba ha ahaatee, haddii testosterone waxaa si deg deg ah ama si weyn u dhimay, waxa ay keeni kartaa in horumarka hypogonadism. gobolka Tani waxa lagu gartaa awood jirka ee ay soo saaraan hormone muhiimka ah, waxay keeni kartaa kala duwan oo ka mid ah calaamadahan, oo ay ku jiraan:

• luma libido;
• hoos ka mid ah wax soo saarka iyo tayada manida,
• kacsi,
• daal.

Haddii aan ka hadlo estrogen, wax ugu horeysay ay dadka u malaynayaa in ay tahay hormone dumar ah, laakiin ay joogaan ay hubisaa in jidhka lab waxaa sii fiican u shaqeeyo. Waxaa jira saddex nooc oo ah estrogens: estriol, estrone oo estradiol. Estradiol - waa nooc ugu weyn ee estrogen firfircoon oo nin. Waxay kaalin muhiim ah in dayactirka shaqo ee xubnaha lab iyo unugyada maskaxda. daroogada Antiestrogen sidoo kale kuu ogolaanayaa shahwada si fiican u yeeshaan.

dheelitir la'aanta hormoon - korinta heerka estrogen iyo testosterone hoos - abuuraa dhibaatooyin. estrogen fara badan oo jidhka ka mid lab waxay keeni kartaa in:

• gynecomastia (horumarinta-dhaafka ah ee unugyada naaska);
• dhibaatooyinka wadnaha,
• halis dheeraad ah stroke ah;
• korodh miisaan,
• Dhibaatooyinka prostate ka.

Waxaad qaadan kartaa dhowr tallaabo si loo soo celiyo dheelitirka ee heerka estrogen. Tusaale ahaan, haddii aad estrogen xad-dhaaf ah waxa uu la xidhiidhaa heerarka hooseeya ee testosterone, in ay noqon kartaa mid waxtar leh sida therapy testosterone of xanibaha estrogen ah.

Pharmaceutical estrogen-blockers

dawooyinka qaar ka mid ah soo saari kartaa saamayn estrogen-ka xanibeen in ragga. Sida caadiga ah, inta badan waxay waxaa loogu talagalay isticmaalka by haweenka, laakiin waxaa lagu helo in dadka ragga, gaar ahaan kuwa doonaya in ay carruurta ka mid ah. Testosterone supplements waxay keeni kartaa dhalmo la'aan. Laakiin blockers estrogen sida "Clomid" celin kartaa dheelitirka hormoon aan wax u dhimin bacriminta.

daroogada Dhowr loo yaqaan modulators receptor estrogen xushay, caadi ahaan suuq sida daroogada lagu daaweyn jiray kansarka naasaha. Laakiin waxay sidoo kale waxaa loo isticmaali karaa si loo joojiyo estrogen ragga. Daawooyinkan waxaa loo isticmaalaa noocyo kala duwan oo xaaladaha la xiriira testosterone hooseeyo, oo ay ku jiraan:

• dhalmo la'aan;
• count shahwada hooseeyo;
• gynecomastia;
• osteoporosis.

daroogada waa in la isticmaalaa eegista, ku xiran tahay qofka bukaanka ah. Isticmaalka daroogada anti-estrogen sida. Farmashiyaha waxaad ka iibsan kartaa:

• "Tamoxin".
• 'Arimidex'.
• "Letrozole."
• "Raloxifene".

Saamaynta ay lafta

Sida laga soo xigtay rugaha caafimaadka, gaadhista dheer daroogada estrogen keeni karaa kansarka baadi gooba in haweenka. "Raloxifene" - modulator a receptor estrogen la xushay - hortagi kara horumarinta kansarka, eegista blocks nuugista ee estrogen. daroogada Tani, si kastaba ha ahaatee, sidoo kale waa awood u anada saamaynta wanaagsan ee estrogen on cufnaanta lafaha. The daroogada cusub - "lasofoxifene" - hagaajin kara dhibaato this. Waxay ka hortagtaa in khasaaraha ka mid ah cufnaanta lafaha dumarka postmenopausal iyo yaraynaysaa brittleness unugyada lafuhu ka. Isticmaalka daroogada tani waa guud ahaan nabad ah, laakiin waxaa laga yaabaa in la kordhiyo xinjiro dhiig.

isdhexgalka daroogada

xanibaha Estrogen "tamoxin" ayaa kaa caawin kara si looga hortago kansarka. dadka qaba kansarka badanaa la kulmaan niyad-jabka, iyo kooxdan oo ah daroogo si xun ula falgalaan laga yaabaa in la daawooyinka, murugada. Waa in lagu dabaqaa "Paroxetine", ay sabab u tahay xaqiiqada ah in haweenka qaadashada "tamoxin" iyo "Paroxetine", halis yar dhimashada badan dumarka qaata "tamoxin" iyo niyad jabka kasta oo kale. Tani waa sababta oo ah "Paroxetine" eegista dhaqmo.

wakiilada Antiestrogen iyo daroogada

The bixinta dhammaan lacagtaas ayaa tilmaamaya in daroogo kasta waxaa si gaar ah loo isticmaalo ee kiis gaar ah.

"Clomid" ama "sitraydh clomiphene" waxa uu ahaa mid ka mid ah daroogada asalka ah loo isticmaalo in lagu daaweeyo gynecomastia, sababta oo ah waxay kicisaa heerka jirka ee testosterone dabiiciga ah. Waxaa jira qaar ka mid ah waxyeelo ka soo isticmaalka muddada-dheer, sida dhibaatooyinka aragga. Waxaa jira walxaha wax ku ool ah oo ku saabsan suuqa, taas oo u dhaqmaan si la mid ah, laakiin "Clomid" Weli waa wax ku ool ah oo jaban isku darka waayo Orodyahanka kasta.

Tani ma aha steroid ah dhiska, daroogada caadi qoray sida gargaarka ah ee dumarka dhalmo la'aan, sababta oo ah waxa uu leeyahay awood la cadeeyay in ay kicin ugxan, oo waxaa lagu gaarayaa by xanibeen / yareeyo saamaynta estrogen ee jirka. Si aad u noqoto si gaar ah, "Clomid" - kiimikaad ee dardaro agonist estrogen / antagonist. In unugyada bartilmaameed gaar ah u xannibi karaa awoodda estrogen si loo xidho receptor u dhigma. Its isticmaalka caafimaad oo waa in ay ka hortagaan -celin xun ee estrogen nidaamka hypothalamus-pituitary-ugxansiduhu ah, taas oo kor u sii daayo LH iyo FSH. Waxaas oo dhan waxay keenaysaa in ugxantu.

Ujeedooyinka ciyaaraha haweenka "sitraydh clomiphene" waxay leeyihiin saameyn ah kuma laha. In ragga, si kastaba ha ahaatee, waxaa kordhay wax soo saarka ee FSH iyo (ugu horayn) farabadan in dareen testosterone dabiiciga ah. saamayn Tani waa gaar ahaan faa'iido u Orodyahanka dhamaadka wareeg steroid marka heerarka testosterone qoomiyadda depress yahiin. Aan testosterone (ama androgens kale), ahaaday "Cortisol" oo saameyn ku Avv borotiinka ee muruqa. Laakiin waxa uu si deg deg ah "cuna" inta badan muruqa cusub helay ka dib markii la joojiyo. Clomid door muhiim ah ka ciyaari kara ka hortagga failure this si loo gaaro natiijada ciyaaraha. Waayo, haweenka, faa'iidooyinka ficilka Clomid - Kartida in la xaddido heerka estrogen qoomiyadda. Tani waxay kordhin doontaa khasaaraha ka mid ah baruurta iyo murqaha, gaar ahaan meelaha sida bowdyaha iyo barida. "Clomiphene sitraydh", si kastaba ha ahaatee, inta badan soo saartaa dhibaatooyin soo raaca haweenka, laakiin, si kastaba ha ahaatee, baahida ka mid ah kooxdan oo ah ciyaartoyda.

"Tamoxin" xanibeen receptors estrogen ee unugyada kansarka naaska. Tani istaago estrogen ka soo lalana iyaga iyo ka hortagtaa koritaanka iyo qeybinta unugyada. Iyadoo "tamoxin" dhaqmo sida antiestrogen ah in unugyada qanjirka caanaha, ay u dhaqmo sida estrogen ah ee xubnaha kale, lafta iyo ilma galeenka.

Dumarka naaska ku tiirsan "tamoxin" kansarka invasive loo isticmaali karaa 5-10 sannadood ka dib qaliinka, si loo yareeyo suurtagalnimada of faafinta metastasis. Waxa kale oo ay yaraynaysaa halista ah ee kansarka naaska kale. Waayo, marxaladda hore ee diyaarinta this ugu horayn waxa loo isticmaalaa bukaannada oo aan dayska sameeyo. inhibitors Aromatase yihiin daaweyn loogu doorbido dumarka wakhtiga ma dhaleysnimada.

"Tamoxin" ayaa sidoo kale laga yaabaa in ay joojiyaan koritaanka ama xataa ihin burooyinka in bukaanka qaba bukaanka kansarka xadka-. Waxaa kaloo loo isticmaali karaa si loo yareeyo khatarta ah ee horumarinta hababka onkologicheskihz naaska.

daroogada Tani waxa laga soo qaatay afka, sida caadiga ah oo ah qaab kiniin.

dhibaatooyinka daroogada anti-estrogen ka mid ah daal, dareenka gubashada ah, qallayl siilka ama mudda iyo isbeddelo ah niyadda.

Qaar ka mid ah haweenka la metastases in unugyada lafuhu ka dhici kara xanuunka iyo bararka murqaha iyo lafaha. Tani waxay sida caadiga ah ma uusan muddo dheer socon, laakiin marmar dhif ah qaarkood, dumarka ayaa sidoo kale laga yaabaa in ay heer sare ah calcium ee dhiigga, taas oo aan la prokontroliruesh. Haddii ay taasi dhacdo, markaas daaweynta waa la joojin karaa in muddo ah.

Waxyeellooyinka naadirka ah, laakiin sidoo kale ka sii daran waa u suurtoobaan. Daawooyinkan waxaa kordhi kara khatarta ah ee kansarka of myometrium ee haweenka la dayska. Kordhinta xinjirowga dhiigga waa saameyn khatar kale oo suurto gal ah. thrombosis xididka Deep dhacdaa, laakiin mararka qaar xoogaa yar oo xinjir dhiig iska jebin kartaa oo ugu danbeyn xannibi halbowlaha ah ee sambabada (lungemboli).

Marar dhif ah "tamoxin" sabab u ahayd stroke iyo wadne dumarka postmenopausal.

Iyadoo ku xiran xaaladda dhaleysnimada ka mid ah haweenka "tamoxin" yeelan karaan saamaynta kala duwan oo ku saabsan lafaha. In haweenka premenopausal, "tamoxin" keeni kartaa khafiifinta lafaha, laakiin in haweenka-dhaleysnimada post kordhiyaa heerka calcium, lagama maarmaanka u ah xoogga lafaha.

The benefits of daroogada this ka miisaan wayn halista ee dhammaan dumarka qaba kansarka naasaha invasive hormone ku tiirsan.

Sidoo kale, daroogada waa "Toremifene", kaas oo la ansixiyey si loogu daweeyo kansarka naasaha xadka-. Si kastaba ha ahaatee, dawadan ma shaqeeyaan haddii ay isticmaalaan "tamoxin", laakiin aan lahayn saamayn.

"Fulvestrant" waa daawo blocks receptor ugu horeysay estrogen, ka dibna waxay sidoo kale ka saaraysaa awood receptor qabanaya ah. Waxay u dhaqmo sida an anti-estrogen jidhka oo dhan.

"Fulvestrant" waxaa loo isticmaalaa in lagu daweeyo kansarka naasaha socda xadka-, oo inta badan la isticmaalo ka dib markii daroogo kale hormoon ( "tamoxin" iyo inhibitors aromatase) ka shaqeeya oo joojiyay.

Waxyeelooyinka ugu badan waxa ka mid noqon kara dareenka gubashada ah, dhidid habeenkii ah, lallabo khafiif ah iyo daal. Fikrad ahaan, waxay wiiqi kartaa lafaha (osteoporosis), haddii aad qaadato waqti dheer.

daroogada Tani ayaa ku guuleystay aqoonsi loo isticmaalo haweenka postmenopausal kuwaas oo aadan ka jawaabin "tamoxin" ama "Toremifene." Waxaa mararka qaarkood loo isticmaalo ay ujeedada looga danleeyahay in haweenka premenopausal, inta badan isku dhafan oo agonist hormone-daayo farabadan oo ah in ay dami ugxan.

"Raloxifene" loo isticmaalo by haweenka ee ka hortagga iyo daweynta lumista lafta ama osteoporosis ka dib dhalmo-dayska. Waxay ka caawisaa si ay u ilaaliyaan lafo xoog leh, yareeyo halista jab.

"Raloxifene" ayaa sidoo kale looga hortagi karaa dhacdo ee kansarka naasaha invasive ka dib dhalmo-dayska. Isagu ma aha hormone estrogen ka, laakiin u dhaqmo sida estrogen qaybo ka mid ah jidhka, sida lafaha. In qaybaha kale ee jirka (naasaha iyo ilmo-galeenka), "Raloxifene" dhaqmo sida xanibaha estrogen ah. Isagu ma caawin noocyo kala duwan oo dhaleysnimada syndrome. Raloxifene la xidhiidho fasalka ka mid ah daawooyinka loo yaqaan estrogen xushay modulators-SERMs (estrogenic iyo daroogada antiestrogenic) receptor.

daroogada Anti-estrogen iyo Sports

Daawooyinka qaarkood ayaa hubkaas ayaa loo isticmaalaa in bodybuilders in la dhiso murqaha.

"Cyclofenil" - waa steroid neanabolichesky / androgenic. Waxaa ka shaqeeya sida anti-estrogen iyo testosterone sida qaadka ah. "Cyclofenil" waa estrogen aad u daciif ah oo khafiif ah, laakiin waxa ay xidhana receptors estrogen iyo ka hortagtaa qabanaya of receptors estrogen dabiiciga ah. Dhab ahaantii, u shaqeeyo si fiican in ciyaartoyda qaarkood ay qaataan daawada inta lagu guda jiro daawaynta a steroid si ay u ilaaliyaan heerarka hooseeya ee estrogen. Natiijadan ayaa waxa ay - yaraynta tirada dareerka ee jirka, kaas oo lagu abuuray steroids iyo hoos u gynecomastia. Orodyahanka waxay leedahay bannaanka adag, isticmaalka daroogada sida, taas oo laga yaabo in la qaado ayaa laga yaabaa inta lagu guda jiro u diyaar tartan. Bodybuilders, si kastaba ha ahaatee, waxaa inta badan ka yar isticmaalaan sababtoo ah waxay door bidaan 'Nolvadex' oo dheeraad ah oo la awoodi karo iyo 'Proviron. "

Like "Clomid", "Cyclofenil" waa ugasii haweenka, sida ay leedahay saamayn togan oo kaliya wax soo saarka ee hormoonnada ragga. Kor u qaadidda heerka testosterone sababa daroogada this kuma filna in laga hadlo horumar xagjirka ah, laakiin waxa ay ku siin doontaa faa'iido xoog, xitaa koror yar ee miisaanka jidhka, koror weyn oo tamar iyo koror wakhtiga cusboonaysiinta, suurto gal. Natiijooyinkaasi waxay yihiin la arki karo gaar ahaan ciyaartoyda sare kuwaas oo waayo-aragnimo yar ama aan la steroids. Isticmaal natiijooyinka noqdaan la arki karo oo kaliya ka dib markii toddobaadkii.

Xaaladaha qaarkood, ciyaartoyda ay daawanayaan Mandheera sida finanka, kor u drive galmada iyo dareen kulayl ah. calaamadaha Kuwani waa gaar ahaan waxay muujinaysaa caddayn in xarunta waa dhab ahaantii wax ku ool ah. Ka dib markii joojiyo of qaar ka mid ah la sheegay dabeecadeed niyadjab iyo hoos u dhac yar oo xoog jidheed. Kuwa ka Yeeshay daroogada sida anti-estrogen inta lagu guda jiro daawaynta steroid, u arki karaan saamayn ka soo horjeeda marka saamaynta wakiilka la joojiyay.

"Proviron" waa mid ka mid ah steroids androgenic dhiska ugu da'da weyn ee suuqa. Si rasmi ah loo yaqaan "Mesterolone", waxa ay weli tahay mid ka mid ah kuwa ugu dhex dhiska users steroid sheegan.

On ku salaysan a functional Proviron leedahay afar hawlood oo waaweyn, kuwaas oo inta badan lagu go'aamiyo ay koorsada of tallaabo. First of dhan, isagu waa mid ka mid ah steroids dhiska ugu awooda badan, maxaa yeelay waxa ay u kordhiyaa qadarka wareegaya testosterone free, taas oo ka badan oo muhiim u ah geedi socodka bodybuilders dhiska. Hab fudud si ay u eegaan waxa at: haddii aad qaadato steroids dhiska, mass muruqa sii kordhaya.

"Proviron®" Waxa kale oo uu awood u leeyahay si ay ula falgalaan aromatase eulayska, kaas oo masuul ka ah beddelidda ee testosterone si estrogen. By ku qabanaya in aromatase, "Proviron®" dhab ahaantii hor joogsada karo waxqabad, sidaas ka waxyeello ka soo gaartey ee estrogen ka ilaalinaya.

On "Mesterolone" sidoo kale waxa uu xidhiidh adag receptor antiandrogen ku. steroid Tani dhiska oo aan lagu cabudhinayo gonadotropins la mid tahay steroids kale dhiska. Tani waxay suuro gelineysaa in la kordhiyo wax soo saarka ee shahwada iyo sidoo kale androgens lagama maarmaan u ah kicinta ee spermatogenesis. Tani ma aha oo kaliya kordhisaa tirada shahwada, laakiin waxay kaloo kordhisaa tayada.

Side Effects "Proviron" ha ku darin gynecomastia ama dheecaan xad-dhaaf ah. Tani waxay sidoo kale si weyn hoos u dhigaysaa khatarta ah cadaadis dhiig oo sareeya ee la xidhiidha qaadashada steroids dhiska. Dhab ahaantii, "Proviron" waxay leedahay saameyn anti-estrogenic by joojinta beddelidda ee testosterone si estrogen, ama ugu yaraan hoos nidaamka this.

The daroogada kor ku xusan ma hoos u heer estrogen, laakiin saamayn shiid guud ahaan.

Kooxdu waxay of daroogada antiestrogenic ayaa sidoo kale waxaa ka mid ah agonister sii daayo qodobo hormoonnada gonadotropic ( "Buserelin" iyo analogs ay), copolymer megestrol ( "Megeys") "Parlodel" iyo "Dostinex" waxaa loo isticmaalaa sida daawooyinka, xannibo dheecaan prolactin. Ay u isticmaalaan in lagu daaweeyo non-buuxa.

Daaweynta kansarka

Waxa intaa dheer in "tamoxin" The soo socda blockers receptor estrogen.

Saddex daawooyinka in ay joojiyaan wax soo saarka estrogen dumarka postmenopausal, ayaa lagu ansixiyay in lagu daweeyo kansarka naasaha labada hore iyo sare: "Letrozole" ( "Femara"), "Anastrozole" ( 'Arimidex') iyo "Exemestane" ( "AROMASIN") .

hab ay of tallaabo daroogada anti-estrogen in kooxdan - ku furid ee eulayska (aromatase) ee unugyada adipose, kaas oo masuul ka ah tiro yar oo estrogen dumarka post-dhaleysnimada. Iyagu ma ay saamayn ugxan, si wax ku ool ah oo kaliya loogu tala galay dumarka kuwa ugxan uma shaqeeyaan, sababta oo ah dayska ama sababta oo ah saamaynta analog farabadan. Daawooyinkan waxaa la qaataa maalin walba qaab ah kiniin. si siman si fiican ay u shaqeeyaan ee daaweynta ee geedi socodka oncological ee naasaha iyo prostate.

Mararka qaarkood daaweynta kansarka naasaha waxay u baahan tahay ugxansiduhu caafimaad. Taas waxaa la samayn karaa daawooyin analogues of farabadan oo hormone hormone-daayo (LHRH), tusaale ahaan, "Goserelin" ( "Zoladex") ama "leuprolide" ( "Lyupron"). Daawooyinkan waxaa xannibi signalka oo soo diro jidhka ugxan in ay soo saaraan iyaga estrogen. Waxay la keligiis ama "tamoxin", inhibitors aromatase isticmaali karaa, "Fulvestrant" for therapy hormoon dumarka premenopausal.