Benzathine benzylpenicillin: description, guryaha iyo codsiga, analogs

Benzathine benzylpenicillin waa antibiotic ah oo iska leh kooxda penicillin ah. Isticmaalaa in lagu daweeyo dhammaan noocyada cudurada faafa ay keento bakteeriyada u nugul in ay tallaabo. In this article aan qeexi doonaa si faahfaahsan tilmaamaha loo isticmaalo, tilmaamo iyo sababo in daroogada, iyo sidoo kale liiska dhowr facooda.

Benzathine benzylpenicillin: sharaxaad ka mid ah daroogada

daroogada Tani waa mid ka mid ah kooxdii ugu horeysey ee antibiotics penicillin. Inkasta oo codsiga muddo aad u dheer, waxa uu ma laga badiyay ay ku tacaluqa ay sabab u tahay kala duwan ee waxqabadyada iyo awood u leh inay dilaan noocyo kala duwan oo bakteeriyada pathogenic. daroogada, tusaale ahaan, la qabsan karaa anthrax, meningococci, waraabowga iyo hannaanka ah streptococci iyo ✰Malax mid. Waxaa la isku duro sida jirta marinka dheef shiidka aan la nuugo benzylpenicillin benzathine.

Recipe ee Latin waxaa inta badan qoray by dhakhaatiirta, ka dibna qofka bukaanka ah waa adag tahay in la garto bal waxa uu la siiyey. Si looga fogaado jahawareer this, kaliya aad u baahan tahay inaad ogaato magaca daroogada oo ku qoran luqadda this - benzylpenicillinum Benzathine.

Sida caadiga ah, daroogada waxaa maamula intravenously ama intramuscularly. Laakiin waxaa suurto gal ah iyo daroogada bixinta jidhka ka galaan dhabarka kanaalka, subcutant ama iyada oo loo marayo meesha ay dhibaatadu saameysey.

Benzylpenicillin - antibiotic ka walax la mid firfircoon ka kooban. Laakiin waxaa gala daroogada ee foomka of cusbada. Sidaas daraaddeed maalkii lagu kaydin karaa waqti dheer oo aan la dumin doono. Oo markii hordhaca ah ee penicillin G la sii daayo jirka ah ee cusbada iyo bilaabaa ay talaabo lid ku ah bakteeriyada.

Iyada oo ku xidhan amarka taas oo cusbadu waa walax firfircoon, jira dhawr nooc oo daawo ah. Iyadoo ay taasi jirto, oo dhan waxay leeyihiin qiyaas ahaan saameyn la mid ah, iyo hababka kala duwan ee maamulka iyo muddada saamayn.

maragga

Benzathine benzylpenicillin wajibiyay ee cudurada soo socda:

• Caabuqyada xubnaha neefsashada (pleurisy, pneumonia, boronkiitada, empyema , iyo si bixi.).
• Cudurada of nidaamka genitourinary (syphilis, jabtada, urethritis, cystitis, adnexitis, salpingitis).
• Infections of mareenka sare ee neefsashada (qandho iyo casaan, qumanka, hogaga, otitis media, hogaga, jidiinka dhuunta, iwm).
• cudurada carow ah oo ka mid ah muuqaal ah xubnaha, lafaha iyo maqaarka, xub-axaleedka (ophthalmia, dacryocystitis, blepharitis, osteomyelitis, mediastinitis, erysipelas, Cellulitis, caabuq ku dhaawacay, sidaas.).
• malax maskaxda.
• meningitis carow ah.
• Septicaemia, sepsis.
• Arthritis.
• Peritonitis.
• Cudurada ay sababaan spirochetes (yaws, anthrax, iwm).
• Qandho ay keento qaniinyada rat.
• Infections sababa Listeria, Clostridium, Pasteurella.

Intaas waxaa sii dheer, daroogada la maamulo ee dhibaatooyinka prophylactically postoperative iyo dhibaatooyinka la cudurka Streptococcus (endocarditis, qandho rheumatic, glomerulonephritis iyo wixii la mid ah.).

Pharmacokinetics

Benzathine benzylpenicillin (Latin Benzathine benzylpenicillinum) si degdeg ah ka dib markii maamulka uu bilaabo inuu sii muuq, sii daayo walaxda firfircoon. Isla mar ahaantaana daroogada ayaa weli ku jira dhiigga ee soo socota 3 todobaad ka dib marka la mudo. walax dareere guskiisa badan ka wanaagsan yahay in unugyada. Waa in la dhasha maskaxda ku haysaa in penicillin benzyl waa ay awoodaan in ay ka gudbaan celiyaha mandheerta kaasi oo u muuqdaan in caanaha hooyooyin carruurtaada nuujiya. Raaca iyada oo kelyaha qaab beddelin. Intii lagu guda jiray 8 maalmood ee ugu horeeya la sii daayay oo ku saabsan 33% ka mid ah qiyaasta ay maamusho.

Uurka iyo naas-nuujinta

Sida kor ku xusan, daroogada waa ay awoodaan in ay dhex gasho mandheerta iyo galaan caanaha naaska. Sidaa darteed, naas-nuujinta waa in la joojiyo marka maamulka daroogada.

Inta aad uurka leedahay, ballan ka mid ah daroogada ayaa suuragal ah keliya haddii lacagta loogu tala galay dumarka waa ka weyn yahay halista ah ee ilmaha. go'aanka waa in la sameeyaa by dhakhtar, digniin hooyo mustaqbalka ku saabsan oo dhan ka dhalan kara.

sababo

Benzathine benzylpenicillin (recipe qori karaa dhakhtar) uu leeyahay tiro ka mid ah sababo. Waa in aan qoro dadka qaba cudurrada soo socda:

• -Diid si ay u penicillin ama cephalosporin, dareen xaasaasi ah iyaga.
• heerka sare ee potassium in dhiigga (hyperkalaemia) ah.
• Arrhythmia.
• qandho Hay.
• neefta bronki.
• kaafi kelyaha.
• colitis Pseudomembranous.

Taxadarka medicament maamula carruurta ilaa lix bilood iyo Dhicis.

waxyeellooyin

Benzathine benzylpenicillin waxay keeni kartaa qaar ka mid ah Waxyeellooyin, iyaga hoos ku tax.

cadaanyo kala duwan:

• qandho,
• finan;
• finan on xuubka iyo maqaarka,
• xanuun wadajirka ah;
• eosinophilia;
• multiforme erythema;
• Cudurka anjioedema,
• dermatitis exfoliative;
• shoog.

dhibaato nidaamka wadnaha iyo,

• Torombositobiiniya;
• anemia;
• xanuunada xinjirowga;
• leukopenia.

Intaa waxaa dheer:

• stomatitis;
• madax xanuun,
• glossitis;
• xanuun degaanka ee maamulka;
• bax;
• dhexgalay;
• Jade durugsan;
• furma.

Iyada oo la isticmaalo daba dheeraaday ee fangaska waxyeello iyo micro-organisms horumariyo kartaa iska caabin ah, ka dibna daroogada waa lumin doonaa, ah waxtarkeeda.

Benzathine benzylpenicillin: tilmaamaha loo isticmaalo

Bukaan-socodka ka weyn yahay 12 sano, daroogada sida qiyaas ka hortagga iyo daaweynta cudurrada faafa waxaa maamula toddobaadkii hal mar at qiyaasta ah 300 ilaa 600 oo kun. Units ama laba jeer bishii at 1.2 milyan oo unugyada.

Sida tallaabooyin ka-hortag loogu talagalay daawaynta sarid laabotooyinka 6 asbuuc, hal mar isbuucii 600 kun oo unugyo. Isla mar ahaantaana qori aspirin ama NSAIDs kale.

Bukaan-socodka da'doodu ka yar tahay 12 sano, daroogada waxaa maamula toddobaadkii hal mar at heerka of 5-10 kun. Units halkii 1 kg.

Inta u dhaxaysa irbado waa inay qaataan meel ugu yaraan 8 maalmood. qiyaasta celceliska 2.3 milyan oo unugyada.

Ka hor inta isticmaalka, daroogada la kala diri ee biyaha cusbada, biyo hoc ad isku duro ama novocaine (2.5% ama 5%).

Soo bandhigay daroogada waxaa laga yaabaa in siyaabaha soo socda:

• muruqyada dhexdooda;
• xididka;
• Maqaarka,
• Lumbar (via kanaalka laf-dhabarta);
• pleural (iyada oo pleura ee sambabada);
• subconjunctival (via unugyada indhaha ah);
• dareerin iyada oo dhegta;
• dareerin sanka,
• si toos ah unugyada xubnaha saameysey.

Isku dhafan oo daroogo kale

Benzathine benzylpenicillin (edbinta si toos ah sida ka muuqata) waxaa laga yaabaa in la daroogooyinka kale ula falgalaan. Sidan buu laga yaabaa benzylpenicillin leedahay tallaabooyinka soo socda: a hammiga, nidaaam iyo bacteriostatic.

Intaa waxaa dheer, daroogada wuxuu kordhiyaa waxtarka daawooyinkaan, tirsan xinjirowga lidka ku ah si aan toos ahayn. Oo yaraynaysaa oolnimada estradiol etinylesttriadiol iyo piller kala duwan.

wada Isticmaal la NSAIDs, allopurinol, natiijooyinka diuretics in dheecaan embriyaha hoos iyo uruureen kor u firfircoon. Intaa waxaa dheer, allopurinol si weyn u kordhiyaa halista ah ee dareen diidmo oo xasaasiyadeed.

tallaabooyin taxaddar

Ay daruuri tahay ka hor inta muday marka hore loo baahan yahay in aspirate. Haddii daroogada si qalad ah uu helo galay xididdada dhiigga, waxay keeni kartaa ischemia ama gufeysan yar. Intaa waxaa dheer, waxaa laga yaabaa in dareen ah walaaca, murugada, aragga indhaha oo isku darsamay transient.

Xaaladaha halkaas oo aad u baahan tahay in la sameeyo labo duriin ah ee waqti, daroogada la maamulo ee hubka kala duwan ama dabada.

Marka daliilka ugu horeeya ee therapy xasaasiyad waa in si degdeg ah loo kala gooyey. Sida laga soo xigtay xaalado laga yaabaa in dhakhtarku kuu qoro dawooyin xasaasiyadda.

Inta la benzylpenicillin magacaabi "Levorinum" ama "nystatin", maadaama ay jirto halista ah ee caabuq fangas. Sidaas awgeed waa therapy muddo dheer daroogada dhici kara Iscelin of microflora xiidmaha oo abuuraa vitamins B. Marka tan la eego, loo qaadan karaa in maamulka muruqyada dhexdooda ee vitamins kuwan.

ganaaxyada

Benzathine benzylpenicillin xilsaaray si taxadir leh ee bukaanka ayaa lagu arkay noocyo kala duwan oo shaqada kelyaha, waxaa jira cabista in daliilka xasaasiyad, iyadoo dareen sare si ay qayb firfircoon. Go'aanka kama dambaysta mar walba iska leh dhakhtarka, kuwaas oo waa in ay ogaadaan taariikhda uu bukaanka.

Aan lagula talinayaa in daroogada lagu daaweyn jiray neurosyphilis, tan iyo markii cudur aan la gaari karaa fiirsashada la doonayo oo ah walaxda firfircoon ee dhiigga bukaanka.

analogs

Waxaa jira daawooyin kale oo ay leeyihiin saameyn la mid ah sida benzylpenicillin benzathine. Analogs, dabcan, ayaa sidoo kale ka tirsan kooxda penicillin ah. Waxaan ku qor ugu caansan oo wax ku ool ah:

• "Gramoks-D" - la soo saaray qaab oo ah budada ah loogu talagalay afgembi iyo maamulka afka.
• "Amosin" - waxaa la soo saaray ee kaabsoosha, kiniin iyo budada ee maamulka afka.
• "Furuqa" - la sameeyo qaab sharoobada.
• "Hikontsil" - heli karaa foomka oo ah budada iyo kaabsoosha maamulka afka.
• cusbo sodium Azlocillin - walax budada ah oo ka kaas oo ka dhigi xal la isku duro xididka.
• "Ampicillin" - waxaa laga heli karaa kiniin, kaabsoosha, dhagaxyada ah, ugu dambeeyey ka dhigi slurry a, oo waxaa afka laga qaato.
• "Ekobol" - saaray kiniin.
• "Ospamoks" - la sameeyo qaab kiniin, kaabsoosha iyo budada ee maamulka afka.
• "Phenoxymethylpenicillin" - waxaa laga heli karaa kiniin, dragees, dhagaxyada iyo budo.
• "Star-Pen" - la sameeyo qaab dhagaxyada ah, kuwaas oo la badhxay oo afka laga qaato.
• "Oxacillin" - la sameeyo qaab kiniin, kaabsoosha, budada ah, kaas oo, xal la isku duro.
• "Standatsillin" - waxaa laga heli karaa kaabsulka.
• Carbenicillin disodium cusbo - waxaa la soo saaray ee budo ah waayo saaridda ee xal duro.

Sayidka, inkastoo isticmaalka xad muddada-dheer ee daroogada ee daawada, uu weli mid ka mid ah wakiilada ugu waxtarka badan ee kala duwan ee cudurada.