"Probenecid": tilmaamaha loo isticmaalo, analogs, dib u eegista

Waa maxay daroogadu "Probenecid"? Tilmaamaha loogu isticmaalo, micne ah, u dhigma iyo tilmaamo loogu talagalay isticmaalka daroogada hoos ku tixi doona.

Form, halabuurka

Waa maxay probenecid? Tilmaamaha on codsiga ah ee sheegashada, taas oo ah walaxda firfircoon oo la helo waa in wax soo saarka badan. Iibso daawooyinka sida uu noqon karaa farmashiyaha wax qiimo ah la awoodi karo. Waxay la soo saaray karaa qaab kiniin, kaabsoosha, iyo xataa budo la joojiyo.

tallaabada pharmacological daroogada

daroogada "Probenecid" Sidee u shaqeeyaan? Tilmaamaha loogu isticmaalo, dib u eegista waxaa arthrifuge taas oo awood u leh in la xakameeyo nuugay ee uric acid ee tubules kelyaha, iyo si weyn kor loogu qaado ay Digo sheegan.

Ayaa lagu soo waramayaa xirfadlayaasha kordhay Digo ee uric acid sarkhaansan oo ah walaxda in su'aasha kordhin karta geedi socodka ka tophi ay sii daayo dhiiga, kaas oo ugu dambeyntii keeni horumarinta weerar ba'an ee turqo.

Sidoo kale, daroogada "Probenecid", tilmaamaha loo isticmaalo kaas oo hoos ku qeexan, inta badan keenta in Digo dhac by kelyaha ee daawooyinka kale iyadoo la kordhinayo ay fiirsashada ee plasma ah. Tani waxay u ogolaaneysaa isticmaalka lacagaha sida daawo dheeraad ah inta lagu guda jiro therapy ah antibiotic.

sifooyinka ogeed

daawo "Probenecid" la nuugo? Marka gudaha ay si buuxda u nuugo ka soo mareenka caloosha iyo mindhicirka. fiirsashada ugu sarreysa ee dhiigga probenecid waxaa lagu gaarayaa saddex saacadood ka dib, iyo brotiin ay ku qabanaya ku saabsan tahay 85-96%.

Halkee cholesterol daroogada hoos tixgelin? Sida laga soo xigtay tilmaamaha, waxaa metabolized beerka. Tani foomamka atsilglyukuronidny aasaasiga ah iyo metabolites kale.

Probenecid waa wax soo saarka by dheecaan firfircoon by kelyaha tubules proximal iyo sifeynta glomerular. In kaadida bukaanka la ogaado oo ku saabsan 75-86% of metabolites ah, oo ka dhiman saxarrada isbeddelin (ku xiran tahay heerka socodka kaadida, iyo aysidhka).

maragga

Taas oo daawaynaya cudurada of daroogada "Probenecid"? Tilmaamaha loogu isticmaalo doodaysaa in wakiilka tani waa wax ku ool ah hyperuricemia muuqato therapy for turqo chronic iyo hyperuricemia isticmaalaya diuretics.

Waxaan ma dhihi karo in iyada oo loo adeegsanayo dheeraad ah daawada waxaa loo qoray si loogu daweeyo of benisiliinta antibiotic iyo cephalosporins.

sababo

Xaaladaha qaarkood, waxaa mamnuuc ah in ay isticmaalaan "Probenecid"? Tilmaamaha loogu isticmaalo waxaa loola jeedaa sababo sida daroogada, sida:

• porfyri;
• weerar ba'an ee turqo,
• inta aad uurka leedahay,
• urolithiasis (oo ay ku jiraan joogitaanka dhagaxyo urate);
• Carruurta ka yar labo sano jir;
• leexashooyinkaasi ee falanqaynta dhiig durugsan;
• diidmo in probenecid;
• hyperuricemia sare oo ka dhalata isticmaalka wakiilada kiimikada, ama geeddi-buro.

Medicament "Probenecid": tilmaamaha loo isticmaalo

Analogues qalab this hoos ku tixi doona.

In daroogada turqo chronic waa in la qaato ayaa laga fekerayaa in qiyaas 250 mg laba jeer maalintii muddo hal bil ah. Toddobaad ka dib markii bilowga daweynta waxaa suurtagal ah in la kordhiyo tirada saxda ah laba jeer.

In case of saameyn ku daweyn ku filnayn ee qiyaasta waa la kordhin karaa bil walba on 500 mg. Waa in la xusuusnaado in qiyaasta ugu badan ee medicament waa 2 g maalintii.

Haddii lix bilood gudahood bukaanka uusan haysan wax weeraro ba'an ee turqo, iyo heerarka dhiig urate aan ka badnayn la ogolyahay, markaas lacagta tilmaamay daroogada lagu si tartiib tartiib ah hoos loogu dhigi karaa si ay wax ku ool ah ugu yaraan (tus, at 500 mg lixdii biloodba mar).

qiyaasta dadka probenecid helo diuretics ama Pyrazinamide kordhin kara.

Marka fulinta daaweynta ka mid ah diyaarinta penicillin antibiotic iyo cephalosporin bukaanada qaangaarka ah warbixinta daawada 500 mg afar jeer maalintii.

In carruurta da'doodu tahay laba sano, qiyaasta hore ee medicament waa in ay ahaataa 25 mg halkii kg miisaanka jidhka, raaceen by sii kordhaya ilaa 40 mg halkii kg. bareeg waqtiga u dhexeeya qiyaasood oo ah daroogada waa 6 saacadood.

In daaweynta jabtada macnaheedu yahay "Probenecid" waxaa loo isticmaali doonaa in qiyaasta ah 1 g halkii nus saac maamulka parenteral ah antibiotic ah.

waxyeellooyin

Maxay yihiin reactions of dabeecad xun waxay keeni kartaa daawada "Probenecid"? Shuruucda LABAGEEDI OO in ay daroogada, si ay u muujiyaan dhibaatooyinka soo socda:

• cuncun, anorexia, nephrotic syndrome, cirridka xanuun;
• madax xanuun, qandho, dawakhaad,
• urtikaria, lalabo, kaadida oo soo noqnoqda, matag,
• leukopenia, Stevens - Johnson, galleeyda cagaarshowga, alopecia;
• anaphylaxis, dermatitis, dhiig, iyo baddu;
• anemia hemolytic, sii xumaanaysa ee turqo, anemia aplastic.

isdhexgalka daroogada

Sida laga soo xigtay edbinta, sida walax firfircoon, sida probenecid, carqaladeeyo kartaa Digo iyo inay kordhiyaan fiirsashada dhiigga daawo sida "Captopril", conjugates "Acyclovir" sulfonamides, "Paracetamol" sulfonylureas "naproxen", aminosalicylates, "Daawada methotrexate" "lorazepam", "meclofenamate", "Rifampicin" "indomethacin", "AZT" iyo "Ketoprofen".

Sidoo kale ogsoonow in daroogada loo arkaa yaraynaysaa-fiirsashada ee nitrofurantoin kaadida iyo penicillamine yareeya ay saameyn ku daweyn at cystinuria iyo cudurada kaadi-mareenka, siday u kala horreeyaan ee.

The medicament "Probenecid" sababa la kordhiyo Digo aminogippurovoy fenilsulfontaleina acid, 5-hydroxy-indoleacetic acid, iyo sulfobromftaleina iyo Digo hoos metabolites hormoonnada steroid ee kaadida.

macluumaad gaar ah

Waxyaabaha aad ogaanaysid hor inta aadan isticmaalin daawada la probenecid? Sida laga soo xigtay tilmaamaha, diyaarinta sida aan la talinayo in la isticmaalo in hyperuricemia sare oo ka dhalata habka tumoral ama isticmaalka wakiilada kiimikada, sida uu sheegay in walax ma yareeyo ereygu wuxuu ahaa ee uric acid iyo kordhisaa kaliya nidaamka Digo kelyaha. Horumarinta ee hyperuricosuria isla waqti kordhin kartaa halista ah ee nephropathy.

Iyada oo taxaddar daroogada warbixinta waa in loo isticmaalo dadka qaba cudurka boog ulcer iyo renal failure raaga. Xaalada danbe, probenecid laga yaabaa in natiijo la'aan.

Marka la isticmaalayo medicament this lagu daaweyn jiray turqo ba'an waxaa kordhi kara ay weerar ba'an, iyo koritaanka kor u calculi kelyaha.

Dadka qaba deficiency G6PD waxay keeni kartaa dhiig yari haemolytic.

probenecid Overdosing keenaya kicinta habdhiska, kor u qalal, oo keeni kara inay sabab u tahay neefta.

Waxaa lagama maarmaan ah si looga fogaado in soo dhaweynta isku mar la probenecid "ketorolac" iyo salicylates.

Dadka qaadashada daroogada this, waxay u baahan tahay qiyaasta hooseeyo "thiopental" maamulka ee suuxdinta.

In codsiga isku midka ah ee methotrexate iyo qiyaasta koowaad probenecid waa in la dhimay si loo yareeyo dhibaatada ay.

Iyadoo qaadashada daroogada this suurto gal natiijada been on baaritaanka kaadida glucose ah.

Analogues, micne ah

Daawada waxaa lagu beddeli karaa by "Probenecid"? Analogues qalab this laga iibsan karaa farmashiyaha kasta. Kuwaas waxaa ka mid ah kuwan soo socda: "Phytolysinum", "Tsitrokas", "Uronefron", "Uroholum", "Baytach", "Cystone", "quo", "phytol", "Urohol" iyo kuwa kale.

Sida micne ah, daroogada noocan oo kale ah waxaa loola jeedaa iyaga u tahay sida "Santoor".

Reviews of arthrifuge

Nasiib darro, dib u eegista macaamiisha, "Probenecid" diyaarinta, ma jiro oo aad u badan. Si kastaba ha ahaatee, markii fariin ah "Santoor" uga haysaan. Bukaan-socodka waxay ku andacoodaan in daawada si fiican loo muujiyey in daaweyn jiray hyperuricemia in bukaanka qaba turqo chronic iyo hyperuricemia marka la isticmaalayo diuretics. Sidoo kale waa wakiilka wanaagsan daweynta cystitis ba'an bakteeriyada, urethritis nonspecific, infekshanka kaadi-mareenka postoperative iyo dhibaatooyin kale urological.

Waa wax aan macquul in aan ku xuso xaqiiqada ah in warbixintan daawada waxaa kale oo jira dhinac xun. iyaga waxaa ka mid ah macaamiisha saamaynta iyo sababo dhinaca aad u tiro badan.