"Octagam": tilmaamaha loo isticmaalo, tilmaamo, waxyeellooyin

Waxaa loola jeedaa in ay daroogada oo kor nidaamka difaaca jirka, "Octagam". Regulations yeeri doonaa in tani ay tahay maandooriye halis ah, oo waxaa la soo bandhigay oo keliya in isbitaalka, si adag on qoro. Waxaa loo adeegsaday bedelka iyo daaweynta immunomodulatory.

Foomka sii daayo daroogada iyo inta ay ka kooban

Waxaa la soo saaray oo kaliya ee foomka of xal diyaarinta galiyey "Octagam". Tilmaamaha ku lifaaqan, waxa uu ku xiran yahay waxbarasho khasab ah ka hor intaadan codsanin. Xalku waa hufan, la-galyadeena hurdi. Daawada waxaa soo saaray fijaan oo dhalooyinka 20, 50, 100, 200 ml, kaas oo lagu xidhi doonaa rabarka ah oo burnishing aluminium buuxiyey oo ku yaal sanduuqa kartoonada ah, halkaas oo lagu daro tilmaamaha loo isticmaalo waa haystaha caag-mesh a.

medicament wuxuu ka kooban yahay in 1 ml oo ah ugu yaraan 95% immunoglobulin G. tilmaame waa u dhiganta xaddiga oo borotiin ku jira plasma dhiigga aadanaha. walxaha dheeraad ah oo ka kooban daroogada waa:

• maltose,
• octoxynol;
• phosphate tributyl;
• biyo irbado.

Daawada waa in aan talaagada ama bandhigan iftiinka qoraxda. Waxaa lagu kaydiyaa heerkulka a of 2-8 ° C, carruurtu gaari karin.

Farmashiiste iyo pharmacokinetics

Drug "Octagam" (manual ka digay ku saabsan sababo iyo ka dhalan kara isticmaalka daroogada) waxyeeleeyo habka difaaca jirka aadanaha iyo waxaa loola jeedaa immunoglobulins.

Daawada waa qayb ka mid ah fasalka immunoglobulin G, kaas oo ay soo saaraan unugyada hababka kala duwan ee faafa ee jirka. daroogada ku jira Banii- ee immunoglobulin ah G, inay isku plasma aadanaha, ku celi dhammaan guryaha iyo dabeecadihiisa. hordhaca ah ee daroogada galay jidhka soo celinayo heerarka hoos IgG, kaxeeyaa in xaalad caadi ah. taagoo IgG sabab u enzymatic iyo gaadhista kiimikada ah isma beddelo. Waxqabadka of antibodies ahaa awoodaan in ay si buuxda u badbaadin.

In diyaarinta "Octagam" ma aha in ka badan 3% polymer, ka dhiman waxaa lagu tiriyaa by monomers iyo dimers wuxuu ku saabsan yahay 90%.

Marka aad la abuuro qalab loo isticmaalo dhiigga 3500 deeq gebi ahaanba caafimaad qaba. Unugyada joogay ee plasma dadka kuwaas oo ku hadhay diyaarinta this bedelin oo weli ku si buuxda oo firfircoon.

Ka dib markii maamulka daroogada galay immunoglobulin xididka G isla markiiba gala wareegga systemic, kaas oo la qaybiyey oo u dhexeeya meesha bannaan ee vascular iyo plasma ah. In codsanaya ah "Oktagama" xaaladda bukaanka ee hagaagtay 3-5 maalmood gudahood. daawo dheefay maalinta 24-36-aad. The bar-nolosha waa ka duwan qof kasta oo ku xiran tahay da'da qofka bukaanka ah, degree of difaaca. Immunoglobulin G ama kaxeynayo kale difaaca jirka ay ku jirto qayb firfircoon, halligay nidaamka reticuloendothelial.

Marka la isticmaalayo "Octagam"?

Codsatay "Octagam" Daaweyn laguugu beddelo, marka waxaa jira syndromes aasaasiga ah difaaca, ugu horreeya oo dhan, hypogammaglobulinemia ah lagu dhasho, agammaglobulinemia iyo Wiskott-Aldrich syndrome. Tani waxaa ka mid ah nooca difaaca unclassifiable variable iyo isku daro immunodeficiencies.

tusmo ee daroogada waxaa loogu tala galay myeloma, foomka chronic lymphocytic. daawada bukaanka qaba cudurada soo noqnoqda, iyo cudurka HIV ee carruurta.

daawo ayaa laga helay ay la isticmaalo ee daaweynta. Taas waxaa weeyaan, waxaa loo isticmaalaa in purpura thrombocytopenic idiopathic (ITP), ku weheliyay halis kordhaysa oo ah dhiig-bax. Sidoo kale, daroogada loo isticmaalo qalliinka ka hor si caadi dhiig xinjirowga. daawada la Guillain-Barré syndrome. Waxay u adeegtaa sida calaamad u ah cudurka Kawasaki in caruurta iyo dadka waaweyn.

Isticmaal "Octagam" (Codsiga User qeexayaa si faahfaahsan habka maamulka iyo qiyaasta of daroogada) ee allogeneic dhuuxa lafaha.

Sababo for infusions

Waxay ka digtay in ay lagama maarmaan tahay in ay qaataan galay account sababo inta aan la isticmaalin "Octagam" tilmaamaha diyaarinta. Ha isticmaalin daawada ay goobjoog ka ahaayeen diidmo in walxaha ay dastuurka ama in immunoglobulins homologous.

Iyadoo daryeelka darafkii ugu magacaabi bukaanka daawada kuwa cayilan. Waxay leeyihiin cabista si ay u horumariyaan thrombosis. Macnaheedu waa u haddii ay jirto a "cudurka dhiigkarka," cudurka macaanka, cudurada nidaamka wadnaha iyo, joogista kordhin aan gaadiidka, la kordhiyo in nafwaayay dhiigga.

Marka nafwaayay sare ee immunoglobulin plasma, galaan dhiigga, oo iska xanaajin halista ah ee Wadnaxanuun myocardial, lungemboli, stroke, thrombosis arooriyaha.

Taxadarka waa inay isticmaalaan daroogada this, bukaanka qaba kelyaha iyo bukaanka la daaweeyo hypovolemia marista wakiilada nephrotoxic. Haddii uu jiro maamul ba'an ee immunoglobulin-yada cudurka kelyaha, "ayuu Oktagamom" therapy la joojiyo.

Bukaanka qaba failure ba'an kelyaha qaab iyo sidoo kale dadka qaba dhibaatooyinka thromboembolic of faleebo ama xidid isku duro, daroogada la maamulo si tartiib ah iyo tiro yar.

Saamaynta ay ku daroogada ee haweenka uurka leh iyo kuwa nuujinaya oo aan ku soo bartay, sidaas muddo ku tilmaamay daawada waa in la isticmaalaa si taxadir leh xad-dhaaf ah. Iyadoo ay taasi jirto, dhaqanka muujinaysaa in isticmaalka immunoglobulins ma dhici karto wax saameyn taban inta lagu guda jiro uurka. daroogada waxay leedahay saameyn ah kuma laha ilmaha caloosha iyo wax saameyn ah kuma ilmaha caanaha hooyada. Immunoglobulins, helitaanka caanaha naaska, ma keenaan dhibaato kasta oo ay u dhashay, iyo unugyada ku jira dhexdeeda, oo kaliya ay gacan formation of difaac xoog leh.

qiyaasta

"Octagam" daroogada la maamulo intravenously kaliya. Ka hor inta aadan bilaabin in lagu diiriyo heerkulka qolka, nidaamka xalka. dareeraha ah waa in uu si buuxda oo hufan oo aan soo dadajin iyo ciida.

Maamulka daroogada kasta waxaa la diiwaangaliyo taariikhda cudurka. Waxaa sidoo kale tirada Dufcaddii daroogada iyo magaca. Taas waxa loo sameeyaa si loo hagaajiyo la socoshada xaaladda bukaanka. Daawada hartay ka dib markii galiyey, ma waxa lagu kaydin karaa oo waa in la tirtiraa.

Heerka hore ee hordhaca sostvlyaet 0.01 in 0.02 ml / kg miisaankiisa jirka ee hal daqiiqo, iyo wixii la mid ah nus-saac. Iyada oo heerka medicament tolerability wanaagsan si tartiib ah waa la kordhin karaa in 0,12 ml / kg miisaanka jidhka halkii daqiiqo.

xaddiga daroogada iyo muddada daawaynta waxaa si gaar ah loogu talagalay bukaan kasta go'aamiyey. Wax walba waxay ku xiran tahay wax ka qabashada caafimaad ee bukaan gaar ah, xaaladiisa iyo ogaanshaha cudurka.

therapy immunomodulating bedelay ee hoos ku lug leedahay xaddi ee immunoglobulin G sii kordhaya in 4.0-6.0 g / l, waxaa lagu qiyaasay ka hor faleebo kasta. Si loo gaaro tiradaasi sida u baahan doonaa 3-6 bilood daaweyn ah. Maamulka dose bilowga ah waa 0.4-0.8 g / kg. Ka dibna daroogada la maamulo bukaanada saddex toddobaad kasta at 0.2 g / kg. Si loo gaaro immunoglobulin diirada 6.0 g / L ah, bukaan-socodka waa in lagu rakibaa on bil kasta 0.2-0.8 g / kg ee daroogada. Marka celinta bukaanka gobolka caadiga ah, daroogada sii soconayo in loo maamulo 2-4 toddobaad kasta, ka dib markii lagu qiyaaso fiirsashada ee immunoglobulin G ee dhiigga. Tani waxay kaa caawin doontaa in aad doorato qiyaasta fiicnayn.

therapy daawo bedelay waxaa sameeyey leukemia lymphocytic chronic, taas oo ag maraaba in hypogammaglobulinemia sare qaab daran, in myeloma, iyo sidoo kale in cudurka of "HIV positive" in caruurta la soo noqnoqonaysa iyo geedi socodka faafa. Qiyaasta sidaas bedbeddeso agagaarka 0.2-0.4 g / kg. Badnaanta ee hordhaca - 3-4 todobaad kasta.

Inta lagu guda jiro daawaynta marxalado xun ee purpura thrombocytopenic idiopathic (ITP) waxaa loo isticmaalaa in qiyaasta a of 0.8-1.0 daroogada g / kg markii ay maamusho maalinteedii kowaad. Haddii loo baahdo, isticmaal ee medicament soo saaray at 2-5 maalin qadarkuu of 0.4 g / kg. Haddii xaaladood oo sii daridda cudurka fadlak, daroogada waxaa mar kale ay maamusho.

daaweynta syndrome Guillain-Barre ku lug leedahay at 0.4 g / kg ee daroogada ah maalin kasta, waayo 3-7 maalmood. Xaaladdan oo kale, isticmaalka daroogada ee carruurta waa mid aad u kooban.

cudurka Kawasaki in carruurta iyo dadka waaweyn lagu daaweeyaa qiyaasta ah 1.6-2.0 g / kg. Daawada waxaa maamula in dose isla badan 2-5 maalmood. Oggol yahay samaynta daroogada hal qadarkuu of 2.0 g / kg. Inta lagu guda jiro daawaynta joogtada ah ee bukaanka ah isku mar la hordhaca ah ee "Oktagama" aspirin loo baahan yahay in la isticmaalo.

Immunoglobulin waxaa loo isticmaalaa ka dib markii daaweyn diyaarinta lafta allogeneic dhuuxa. Maamulka daroogada ah ka hortagtaa dhacdo ee cudurka iyo horumarinta syndrome ee "jab kasoo horjeeddo ciidankii". qiyaasta ee bukaan kasta la doortay si gaar ah. Waxaa lagu talinayaa in la bilaabo ka dose oo ah 0.5 g / kg todobaadkii. nidaamka isku duro waa in ay bilaabaan todobaad ka hor badalida soo socda ee xubnaha. Therapy sii muddo seddex bilood ah qalitaanka ka dib. Haddii ay jirto la'aan joogta ah immunoglobulins, daawada loo isticmaalo in lagu 0.5 g / kg bil kasta inta ay content umana yimaado heerka caadiga dib.

waxyeellooyin

Subject baadhitaan khasab ah ka hor inta codsanaya daawo "Octagam" diiwaanka. Horumarinta ee waxyeellooyin marka la isticmaalayo daroogada waxay ku xiran tahay xadiga iyo heerka maamul.

duro xididka la daroogada waxay keeni kartaa leukopenia, hemolysis iyo dhiig hemolytic karo. In daaweynta falcelinta suurto gal xun ee habka difaaca jirka, kaas oo lagu muujiyay in muujinta diidmo. Marar dhif ah kici anaphylactoid iyo ficil-celintan jirka, barara wejiga, anjioedema.

therapy HIV ee carruurta iyo daaweynta cudurrada kale ee badanaa keentaa madax xanuun. Waa cudur maskaxda dhif u ah ee wareegga dhiigga, farax xad-dhaaf ah, aseptic meningitis. daroogada waxay keeni kartaa madax xanuun, paresthesia iyo vertigo.

Inta lagu jiro daaweynta, waxaa jira ixtimaal ah dhacdo of Wadnaxanuun myocardial. Waxaa laga yaabaa in garaaca wadnaha oo kor iyo tahikradiya. Mararka qaarkood walwalsan dhiigrooraan, hypotension iyo thrombosis. Waa dhif la'aan wareegga dhiigga, thrombosis xididka qoto dheer, hypertension.

daroogada waxay keeni kartaa dhib falcelin ah on qayb ka mid ah habka neefsashada. Tani neefta, barar sambabada, neefta oo ku qabata. The cawaaqib xun loogu muujiyo taam ah qufac, bronchospasm, lungemboli.

Daaweyntu waxay keeni kartaa lallabo, matag reflex, calool xanuun, shuban. Marar dhif ah, waxaa jira cambaarta, cudurrada urtikaria iyo cuncun. In bukaanka qaar ka mid ah, ka dib markii la isticmaalayo daroogada kacay dermatitis, alopecia, iyo pruritus.

Waxaa si dhif ah cadaanyo arkay sida xanuun ka dib goobta, myalgia iyo arthralgia. More in daaweynta waxa dhici karta in kaafi kelyaha, kor u kariyaatiniin serum, rabshin qandho, daal xad-dhaaf ah, dareen-celin raaxo dhacaan goobta la duray. Waxaa ka mid ah dhacdooyinka si kaladuwan loo kasin arkay qarqaryo, xanuunka xabadka, bafinayo, qidmeyntiibulshada, finan iyo pyrexia. Jiraan xaalado dhif ah, bukaan dhiig cadaadis hoose, shoog.

muuqaalka kore ee waxyeellooyinka suurtagalka ah ee bukaanka, maamulka daroogada dulqaadan hore si fiican. "Octagam" sababa la kordhiyo ensaymes beerka iyo uruureen glucose ee waxbarashada dhiig shaybaarka.

Marka si fiican loo soo xulay dose dhici kara overdosing calaamadaha. Waxaa sida caadiga ah waa dareeraha ee jirka, la kordhiyo ku nafwaayay dhiigga, taas oo loo arkay in dadka cudurka kelyaha, iyo in bukaanada waayeelka ah.

In dhammaan xaaladaha kor ku xusan, daaweynta calaamadaha lagu talinayaa.

ganaaxyada

Daawada waa awoodaa in la yareeyo saamaynta tallaalka fayruska fayruska nool muddo lix toddobaad ilaa saddex bilood. Si looga hor, waa in aad sugtaa ka dib markii codsiga ah ee "Octagam" saddex bilood of diyaarinta. Daawada yaraynaysaa waxtarka tallaalka jadeecada ee sanadka, si hor dhaqangalka ah ee tallaalka this waa in la hubiyaa antibodies-baadh oo jadeeco.

Daaweynta la daroogada this waxay keeni kartaa dhowr ah oo dhibaatooyin soo raaca, sidaas darteed waxaa lagama maarmaan ah in ay si adag u hoggaansamaan tilmaamaha qiyaasta iyo heerka maamul. In koorsada of therapy loo baahan yahay mar walba in lala socdo caafimaadka bukaanka.

Bukaanka waxaa maamula immunoglobulin xididka, waa in ay helaan biyo ku filan ka hor habka, si ay u qabtaan socodka saarka kaadida iyo kariyaatiniin dhiigga. lagama maarmaan u tahay in gabi ahaanba meesha laga saaro codsiga ah "loop" diuretics.

Haddii ay jiraan dareen diidmo xun loo baahan yahay si loo yareeyo heerka maamul daroogada ama gebi ahaan la joojiyo isticmaalkiisa. therapy waxay ku xiran tahay gebi on darnaanta iyo nooca dhacdada aan loo kasin. Haddii ay jirto lama filaan ah, waxaa lagama maarmaan ah in ay door biday in ay therapy anti-filaan ah, taas oo waa in la isku daro leh daaweynta.

Inta badan sababa dhibaato heerka deg deg ah ee maamulka, gaar ahaan hypo- iyo agammaglobulinemia oo codsanaya immunoglobulin hoose. Dhibaatooyinka ay keento dhici kara marka wareejinta bukaanka qaba immunoglobulin mid soo saaraha in ay daroogada kale, iyo haddii ay waqti badan ayaa soo maray tan iyo faleebo ee la soo dhaafay.

Control oo ka mid ah bukaanka (oo ka mid ah bukaanka qaba xaaladda HIV-positive) waa in si joogto ah ay fuliyeen mudada of faleebo ugu horreeya ee tallaabo, gaar ahaan inta lagu jiro saacadaha ugu horreeya ka dib markii nidaamka. Bukaanka qaba waxyeelo ma laha, waxa uu noqon waa in ka yar kormeer dhakhtar galiyey "Oktagamom" 20kii daqiiqo ee ugu horeeya ka dib.

Inta lagu jiro daaweynta waa in ay qaadaan tallaabooyinka caadiga ah si looga hortago cudurada, in waa u suurtoobaan marka la isticmaalayo daawada ka dhiigga dadka ama plasma sameeyey. Waxaa ka mid ah doorashada ee deeq-bixiyeyaasha ku haboon, la socodka ah ee la cuno iyo balliyo plasma for calamado gaarka ah ee cudurka shaqsi. hannaanka waa in ka mid ah tallaabooyinka loogu talagalay inactivation / tirtiridda fayrusyada.

Inkastoo taxadar kasta ee daaweynta daawooyinka sida, waxaan meesha kama saarayso suurto gal ah kala iibsiga ee tiro ka mid ah wakiilada ee cudurada, fayrusyada iyo wareer kale. Dhamaan tallaabooyinka kor ku shaqeeyaan go'aan ka soo baxay fayrusyada Ciqaahtii HIV, cagaarshowga nooca B iyo C. yaraan ay go'aan ka sidayaal ee B19 parvovirus iyo gipatita A. aragnimo Clinical wakiilada daaweynta ka kooban immunoglobulin aadanaha jeedisay in B19 parvovirus iyo hepatitis A ee daaweynta ee daroogada xogta isugu ma gudbiyo. Of muhiimadda ugu weyn ee badbaadada fayruska ay joogaan in sheyga daawo u dhiganta antibodies.

Inta lagu guda jiro marinka ee koorsada daweynta antibodies lahaayeen wareejiyo in dhiigga qofka bukaanka ah siin karaa natiijada been ah markay fulinayaan baaritaano serologic. Maltose ku jira diyaarinta awoodaa been yaynaan heerka sonkorta dhiigga.

waxqabadka Hagaajiyey ee fiirsashada gulukooska ee dhiigga lagu arkay inta lagu guda jiro saarista daroogada ka shaqeeyo ama shan iyo toban saacadood ka dib markii la xiro. Xaaladdan oo kale, waxaa suuro gal ah ee dose insulin Ujeedada aan sax ahayn in cadhaysiinina kartaa hypoglycemia. Sidaa darteed, kaliya hababka glyukozospetsificheskie lagu ogaanayo heerka glucose ee dhiiga in loo isticmaalo in lagu daaweeyo "0ktagamom". xirmooyinka Test for sonkorta dhiigga la socodka waa in ay awoodaan in ay go'aan ka dhimaya this ee bukaanka qaadashada daawooyinka la maltose.

Haddii ma ay dhammaan, ka dibna loo ogol yahay in ay ku kaydiso daroogo "Octagam" (50 ml oo 100 ml) heerkulka ilaa + 25 ° C muddo saddex bilood ah aan sare u geliya qaboojiyaha. Aan la isticmaalin muddo cayiman, daroogada waa in la tirtiraa.

Daawada uusan saamayn ku lahayn awood u leh inay la wado iyo in ay sameeyaan tallaabooyinka u baahan galaasyada fiiro gaar ah iyo reactions psychomotor degdeg ah.

Drug "Octagam": dhigooda

daawada waxa uu leeyahay tiro ka mid ah analogues isaga bedeli karaa marka loo baahdo, waa:

• "Biaven VI."
• "Veegum-hantidooda."
• "Venoglobulin".
• "Gabriglobin".
• "Gabriglobin-IgG».
• "Veegum-C."
• "Gamunex."
• "Gamma globulin Hooman".
• "IG Vienna N.I.V. ".
• "Imbioglobulin".
• "Immunoglobulin".
• "Imbiogam".
• "Immunovenin".
• "Intratekt".
• "Sandoglobulin".
• "Endobulin".
• "Flebogamma 5%."
• "Humaglobin".

keydka Ruush yihiin wax badan ka jaban ka badan dhigooda shisheeye. Si kastaba ha ahaatee, daawooyinka oo dhan daran ku filan oo ay qaado yihiin iyo waa in la beddalo kaliya dhakhtar, ku salaysan xaaladda bukaanka.

"Octagam" Daawo: qiimaha

Qiimaha daroogada waa mid qaali ah. Waxaa laga iibsan karaa 9,5-12 kun rubles iyo 50 ml of daroogada "Octagam". 100 ml Price waa agagaarka 20-24 kun oo rubles.

The views bukaanka iyo dhakhtarrada

Drug "Octagam" ayaa dib u eegista ay inta badan wanaagsan. Gaar ahaan mahad dadkeeda tayo leh, kii uu ka caawiyay inuu ka soo kabsado leh difaaca iyo Guillain-Barré syndrome. Waxaa inta badan loo isticmaalaa dadka qaba AIDS ilaaliyaan caafimaadkooda. Waxa uu cadeeyay inuu yahay wax ku ool ah leukemia lymphocytic chronic, daweeyay gravis. Haweenka isticmaalaan daroogada this in aad uur yeelato oo waxaad dhali doontaa ilmo.

Inta badan bukaanka qanacsanayn kharashka daawada, waxay la soco in waa ay adag tahay si ay u iibsadaan farmasiyada. Qaar ka mid ah waxaa loo bixiyey tabar ah, madax xanuun, iyo u qidmeyntiibulshada ee guud.

Dhakhaatiirta ayaa sheegay in in ay tahay diyaarinta saafi ah, waxaa si fiican jidhku u nuugo, oo ka duwan immunoglobulins qoyska yar tahay in ay keeni xasaasiyad.