Hyperandrogenism dumarka: sababa, calaamadaha, daaweynta. hyperandrogenism The halista ah ee haweenka

In daawada, dhibaato loo yaqaan hyperandrogenism dumarka. Sababaha, calaamadaha, daawaynta cudurka noocan oo kale ah u baahan tahay qiimeynta iyo ka qaybgalka dhakhaatiir aqoon u leh. Inkastoo cudurkan waa mid aad u adag tahay in si buuxda looga guulaysanayo, ugu noqon inuu dhakhaatiir wanaagsan oo aan dib u dhac.

Nuxurka cudurka

Marka ay timaado in cudurkan sida hyperandrogenism haweenka, sababa calaamadaha, daaweynta iyo tallaabooyin ka hortag ah waxaa mar walba la xiriira dhibaato noocan oo kale ah, sida saamaynta on adrogenov jidhka. Marxaladani waxay keenaysaa in muuqaalka kore ee muuqaalka dhaddig oo sifooyin rag ah, iyo isbedel kale oo aan si wacan. In faahfaahin dheeraad ah, waxaan ka hadleynaa daliilka sida muuqaalka kore ee timaha wajiga iyo timaha jirka, cod qoto dheer sida, oo badala qaar ka mid ah tiradaasi xubno.

Waxaa xusid mudan in xaqiiqda ah in nidaamka hormoonada jidhka ee cudurada haween ah waa wax caadi ah, iyo ma aha oo kaliya waxay keeni kartaa in isbedel xun dibadda, laakiin sidoo kale ka dhigi dhalmo la'aan. Sidaa darteed, marka calaamadaha ugu horeeya ee hyperandrogenism, waa in si degdeg ah ballansatid booqasho la dhakhtarka.

Maxaad horumarinta cudurada a

Mawduucan ah "cid hyperandrogenism dumarka: sababa calaamadaha, daaweynta» Waa arrin aad u muhiim ah in la jinsi ah caddaallad ah, sababtoo ah dhibaatada lagu muujiyay in qiyaastii 20% bukaannada. Sidaas waxa macno in ay bixiyaan si ay arrimaha iyo dariiqooyinka u hogaaminya horumarinta cudurka this dareenka.

Sababta ugu weyn ee la go'aamin karaa wadareedka - adrenogenital syndrome. line hoose waa in qanjidhada adrenal awood u soo saara hormoonada kale oo badan, marka lagu daro adrogenov, sida glucocorticoids. Arintaan muuqan sarkhaansan enzyme gaar ah. The saldhig ay dhacdo ururtay androgens. Mararka qaar dumarku hore u joogay ee cillado lagu dhasho ee eulayska, taasoo keentay in a hormoonnada lab aan diinta oo laga soo ururiyey si joogto ah, noqday sabab oo ka mid ah isbedel xun ee jirka dhaddig.

Waxaa jira habka kale, taas oo uu yeesho sabab u hyperandrogenism asal adrenal. Waxaan ka hadleynaa burooyin ka mid ah qanjidhada adrenal. Waxa kale oo la aasaasay oo ku saabsan asalka ah ee sii kordhaya uruureen of androgens.

Khatarta cudurka kor ku xusan ay u muuqataa in ay dhacdo marka uu jiro wax soo saarka ka mid ah hormoonada lab ahaa ee ugxan dumarka. Waxaa intaa dheer, unugyada in ay soo saaraan Adrogué keeni kartaa formation buro ee ugxan.

hyperandrogenism syndrome mararka qaarkood waa natiijada gaadhista heley hormoonada jidhka ee xubnaha kale, sida qanjirka pituitary ee.

Calaamadaha xad antiandrogen

Haddii aan ka hadlo astaamaha caafimaad ee ay isugu soo urureen kacsantahay ee hormone lab, waxay lagu tilmaami karaa sida soo socota:

• finan;
• in timaha foodda iyo dhibco bidaarta (adrogennaya alopecia);

• qanjidhada Qanjirrada bilaabaan inay soo saaraan xaddi dhaafka ah ee dheecaan, taasoo keentay maqaarka korodhka saliid leh,
• barifoniya in macnaheedu qoto codka;
• on caloosha iyo xabadka timaha muuqdaan.

Waxaa xusid mudan in xaqiiqda ah in hirsutism - koritaanka xad-dhaafka ah ee timaha terminal on jidhka dumar ah, waxaa lagu gartaa in 80% dadka qaba dhibaato this sida hyperandrogenism syndrome.

Iyada oo cudur noocaas ah in qaar ka mid ah galmada carqalad ku caddaallad suurto galka ah ee caadada, maqnaanshaha dhamaystiran oo caadada, iyo sidoo kale myocardial hypertrophy, cayilka, dhalmo la'aan, iyo dhiig-karka.

fiirsashada ee hormoonnada lab keeni kartaa Faahfaahin of nuglaato jidhka dumarka cudurada of noocyo kala duwan. Sidoo kale waa suurto gal daal iyo janjeera in ay niyad-jabka.

Finanka iyo Qanjirrada qanjidhada

Si aad si cad u fahmaan waxa ay sameeyaan dhibaato noocan oo kale ah sida hyperandrogenism haweenka, sababa, calaamadaha, daaweynta, iyo cudurka waa in ay tixgelisaa si fiican. Sida sababaha keenaya horumarinta cudurka, ayaa lagu kor ku xusan ka wada hadleen, waxa macno u bartaan dabeecadaha calaamadaha.

Marka aad taaban dhibaatadan sida finanka, waxaa xusid mudan in ay yihiin natiijada keratinization derbiga follicle iyo wax soo saarka sebum kordhay, kaas oo u dareen uruureen antiandrogen, oo ay ku jiraan plasma. Marka calaamadaha sida caadiga ah waa COCs qoray ama antiandrogens, kaas oo u ogolaanaya si weyn loo hagaajiyo xaaladda bukaanka.

Sidoo kale sarkhaansan hormoon oo lab goobaha androgenozavisimyh muuqan midabka, qaro weyn, timo dhab ahayn halkii vellus. Tani waxay badanaa ka dhacdaa qaangaadhnimada. Xaaladdan oo kale, saamaynta antiandrogen on sunnayaasha, baarkooda, qaybo temporal iyo occipital waa ay yar tahay.

hyperandrogenism adrenal

Waxaa xusuus mudan in qanjirka adrenal - waa laba qanjidhada hormoonada jidhka in yaalaan oo kaliya kor isu kelyaha.

Waxay yihiin halka uu 95% soo saaray antiandrogen (DHEA-sulfate). kakanaanta ee hyperandrogenism la xidhiidha qanjidhada, kuwaas oo, hoos, booguhu xaqiiqada ah in cudurada waa lagu dhasho ee dabiiciga ah iyo dhigaysa laftiisa dareemay ku saabsan asalka androgenitalnogo syndrome. Waxay keenaysaa in hoos u dhac in heerka muhiimka ah ee falgalka jirka dumar lagama maarmaan ah in ay soo saaraan hormoonada sida glucocorticoids.

Hyperandrogenism of oubslovlena asal adrenal waa this deficiency, taas oo keenta in la kordhiyo ku uruureen ka mid ah hormoonada kale - pregnenolone, progesterone, iwm isbedel noocan oo kale ah ay dhammaystirmaan soo saarka sii kordhaya ee antiandrogen ee jirka dumar ah..

Mararka qaarkood cudurka cudurada, taas oo sabab u ahaa burooyinka ku dhaca qanjidhada adrenal in ay soo saaraan hormone lab. Sida laga soo xigtay tirakoob, foomkan cudurka sida hyperandrogenism ee adrenal fadhiya in 30-50% haweenka dhibaatada antiandrogen.

Saameynta ugxan

-fiirsashada sare ee hormoonnada lab saamayn ku yeelan karaan hawlaha ugxan. Xaaladaha intooda badan, dhibaatada taas oo ka dhigaysa laftiisa dareemay iyada oo laba nooc: gipertekoz iyo polycystic. Waxaa muhiim ah inaad bixiso si ay xaqiiqada ah in halista cudurkan haweenka waxay kordhisaa la jimicsi joogto ah ciyaaraha awooda dareenka.

hyperandrogenism ugxansiduhu waa natiijo ah oo hoos gaabis koritaanka kiishashka sarkhaansan androgens. Sababta oo ah ugxan, kuwaas oo ka kooban, natiijada la marayo sida uu noqdo ee la soo dhaafay imperforate. Magaca caafimaadka ee dhibaatada this - atresia dalool.

Laakiin ma ahan oo dhan dhibaato ah in raaci Bilowgii hyperandrogenism ugxansiduhu. line hoose waa in hormone lab dhaqmo sida arrin ka dhanka ah oo uu yeesho formation of unugyo aan caadi ahayn buunshada ku, taas oo horseedaysa polycystic. Xaaladdan oo kale, waxaa war fiican ah xaqiiqada ah in dhibaato la mid ah soo food saaray% dumarka oo kaliya 5.

Sidoo kale xusid mudan tahay, in foomkan of hyperandrogenism, jinsi ah caddaallad ah waa sababta oo ah failure of regulation dhexe ee heerka antiandrogen. Marxaladani waxay dhacdaa heer ka mid ah hypothalamus oo pituitary. Sida ka dhalata isbeddellada hormoon si weyn.

Calaamadaha waa in aad fiiro gaar ah

Waxaa jira tiro ka mid ah calaamadaha muujinaysa dhacdo ee dhibaatada kor lagu sharaxay. Xaqiiqada ah in aan u leeyihiin in ay noqon sida cudurada ka soo jeedo hyperandrogenism ugxansiduhu, waxaa laga heli karaa daliilka soo socda:

• osteoporosis;
• seborrhea;
• wajiga, marka lagu daro finan, waxaa jira hoolmay iyo barar, taas oo ay adag tahay in takhalusi lahaayeen habab caadaysi Qurxin;
• atrophy muruqa;
• cayilka;
• beddelo Joogaba, ee jidhka dumarka - masculinization;
• qoto codka (barifoniya);
• koritaanka timaha jirka oo dhan, xitaa wejiga;
• formation of sharooto bidaarta on madaxa.

Intaa waxaa dheer, waxaa jira calaamado badan oo sare, sida kor u kacay heerka dhiigga glucose, hypertension halbowlaha, difaac hoos u, iyo kuwa kale.

miisaanka xad-dhaaf ah

Cayilka dumarka keeni kartaa hyperandrogenism ugxansiduhu kor lagu sharaxay. In foomkan cudurka waxaa badanaa go'an kor estradiol.

Daraasad caafimaad oo la sameeyay, sida laga soo xigtay kuwaas oo xaqiijin macluumaadka soo socda: sida sare heerarka hormone lab, iyo sarkhaansan ay of estrogens leeyihiin saameyn toos ah ku ah horumarinta cayilka, nooca lab dhiganta.

Nidaamkan waa mid yihiin sababta keentay cod insulin-tiirsane ah iyo ka-fiirsashada xiga ee hormone koritaanka ee jirka ka mid ah haweenka lab ka cabanaya xanuunada kor lagu sharaxay. Xaaladaha qaarkood, androgens saameeyaan haweenka aan hooseeyo iyada oo loo marayo habka dhexe ee neerfayaasha.

foomka isku qasan

Dhakhaatiirta si joogto ah u leeyihiin in ay la noocyo dhowr ah oo ka muuqan of hyperandrogenism ka qabtaan. Xaaladda waxa lagu sharaxay by xaqiiqada ah in waqti isku mid ah waxaa jira xadgudub ah oo ka mid ah hawlaha adrenal iyo ugxansiduhu.

suuragalnimada in dhibaatooyin kale waa muhiim in la tixgeliyo in daraasadda waxa hyperandrogenism halista ah ee haweenka. Dhab ahaantii, tani dhacdo, androgens adrenal, feejignaanta ee qanjidhada adrenal, sidaas kor loogu qaado heerka hoormoonka lab ahaa ee ugxan. Marxaladani waxay dhacdaa dhiigga, taas oo keenta in wax soo saarka kor u farabadan. Arintaan, markeeda, dhirfinaya muuqaalka kore ee hyperandrogenism syndrome.

Dhacdo foomamka lagu daray of cudurada loo saarin karaa in dhaawacyada daran, maskaxda ah wanataas ama buro pituitary.

Baadhista xanuunada

Marka hore, dhakhtarka waa in la kala soocay cudurada kale hyperandrogenic kuwaasoo ay ku horumarineyso (Acromegaly, Cushing ee syndrome, cudurrada beerka iyo kuwa kale.). Tallaabada xigta waa in la go'aamiyo heerka hoormoonka. Habkani waa in la fuliyaa calool madhan subaxdii. Falanqaynta noocan oo kale ah waa in ay qabtaan saddex jeer sida hormoonnada la fiirsashada antiandrogen sare waxaa si joogto ah la beddelo.

Ogaanno waxaa lagu sawiray heerka dehydroepiandrosterone, waxyaabaha sare ee kaas oo noqon doona caddaynta hyperandrogenism adrenal. Waxaa kaloo muhiim ah iyo heerka ketosteroids kaadida. Haddii content uu yahay mid ka baxsan iska caadi ah, waxa macno u ka shakisan tahay horumarka cudurada.

daaweynta

Hyperandrogenism - tani waa mid aad u halis ah arin in ay iska indha gargaar ka dhakhaatiirta u qalma. Oo haddii aan u falanqeeyaan koorsada oo dhan daaweynta, waxaa lagu soo gabagabeeyey karaa in ay waxaa loogu talagalay gaaro afar Ujeedooyinka ugu muhiimsan:

• daliilka maqaarka ka kaxaynta;
• caadi ah wareegga caadada,
• daaweynta dhalmo la'aan, taas oo sabab u ahaa anovulation;
• tirtiridda iyo ka hortagga cudurada dheefshiidka la xiriira cudurka hoose.

Cuntada loogu talagalay hyperandrogenism dumarka waxaa loo doortay in ay dhacdo miisaan weyn u kordhay. Xaaladdan oo kale, waxaa muhiim ah in si sax ah raacaan dhammaan talooyinka dhakhtarka, kaliya ka yar xaalad this, waxaad ka heli kartaa natiijada saxda ah.

Kuwa bukaanka u socdaan in ay dhalaan ilmo, in kiisaska intooda badan, qori therapy hormone siin kara ugxan buuxda.

Haweenka aan loo uur yeelato, mari daawada, oo ay ku jiraan piller, iyo xaaladaha qaarkood, resection waslad ugxansiduhu.

U diyaar garowga daaweynta hyperandrogenism dumarka waxaa sidoo kale si firfircoon loo isticmaalo, haddii jidhku waa awoodi waayeen in ay uga takhalusi lahaayeen heerarka sare ee antiandrogen oo keliya. Waxaan ka hadleynaa qalabka sida "metipred" "Dexamethasone", iyo qaar kale. Qalliin lagu soo rogay waxaa laga yaabaa in ay dhacdo in kiciyay cudurada burada.

natiijooyinka

-fiirsashada sare ee hormoonnada lab ee jirka dumar ah - waa ka badan tahay dhibaato khatar ah in inta badan uu yeesho ku saabsan asalka ah ma cudurro halis ah ka yar. Sidaa darteed, marka astaamaha cudurka hore iyo daaweynta waa in la fuliyaa laga baajin.