Daawada "Ofloxacin": Kurtumm bukaanka. Tilmaamaha loogu isticmaalo ee ah antibiotic "Ofloxacin"

Diyaarinta "Ofloxacin" bukaanka ratings oo inta badan fiican, wakiil ka wakiilka antimicrobial ka tirsan ee fluoroquinolones spectrum ballaaran oo waxqabad. daroogada ayaa saamayn ku gyrase ee DNA - jab bakteeriyada, bixinta supercoiling oo sidaas daraaddeed xasiloonida ee bakteeriyada DNA (iyada oo sababtu tahay xasillooni ee DNA dhinta strand ah).

pharmacodynamics

Oo macnaheedu yahay "Ofloxacin" - antibiotic wax ku ool ah oo la tixgelinayo sheyga in ay soo saaraan beta-lactamase, iyo sidoo kale dee- atypical dhakhso u kordhaya. Si aad daawo u nugul yihiin, ugu bakteeriyada Gram-negative, oo ay ku jiraan sheyga in ay yihiin adkaysi u Methicillin iyo antibiotics kale. Streptococci, enterococci, iyo Mycobacterium tuberculosis waxaa lagu gartaa nuglaato deganayn si daroogada "Ofloxacin". Reviews dhakhtarro ayaa tilmaamaya in lagu daaweeyo cudurada anaerobic sababa peptostreptokokki, peptokokki iyo anaerobes kale, daroogada waa inta badan xumaada.

Pharmacokinetics

Marka la helo medicament galay nuugista waa dhameystiran (95 boqolkiiba) oo degdeg ah. Bioavailability - in ka badan 96 boqolkiiba. Xiriirka borotiinada plasma - 25 boqolkiiba. Ka dib markii mid ka mid ah laba saacadood ka dib markii maamulka afka fiirsashada ugu sareeya gaadhin. Waa qiyaasta ku tiirsan: isticmaalka hal ka mid ah laba boqol, afar ama lix boqol oo milligram fiirsashada daroogada ayaa waxaa ay u kala horreeyaan 2.5, 5 ama 6.9 ug / ml.

isticmaalka cuntada saamayn ku yeelan kara nuugista ee dhanka ahayd ariinta ah, laakiin ma saameyn weyn ku bioavailability. Diyaarinta "Ofloxacin" - antibiotic ah isagoo mugga weyn ee qaybinta (boqol gallon), sidaa darteed in diyaarinta maamulo waa ku dhawaad qadar buuxa guskiisa si xor galay unugyada. Tirada ugu badan tahay in unugyada, dheecaannada jidhka iyo xubnaha: unugyada (macrophages alveolar, leukocytes), unugyada jilicsan, maqaarka, lafaha, neefsashada, saabka miskaha iyo caloosha, candhuufta, dheecaanka Prostatic, kaadida, bile. ceelka medicament guskiisa mandheerta kaasi oo caqabad dhiig-maskaxda, waxaa ku qarisay ka caanaha naaska, iyo cerebrospinal galo at xuubka maskaxda non-barar iyo barara (14 ilaa 60 boqolkiiba).

About 5 boqolkiiba daroogada la metabolized in beerka si ay u sameeyaan dimetilofloksatsina iyo N-xabagta of ofloxacin. Ayadoon ku dose bar-nolosha waa u dhaxeysa afar ilaa iyo badh ilaa toddoba saacadood. Output daroogada beddelin qadarkuu of 75-90 boqolkiiba kelyaha, qadarkuu of 4 boqolkiiba - in bile ah. In ka yar 20 boqolkiiba ansixin extrarenal. Ka dib markii dhoos keli ah laba boqol miligaraam oo ah wakiilka waa dareemi kaadida for 20-24 saacadood. In the case of Digo cagaarshowga ama kelyaha la yareeyey laga yaabaa. Marka dialysis waa laga saaray 10 ilaa 30 boqolkiiba daawada.

Tilmaamayaasha waayo,

In cudurrada faafa iyo bararka sababa sheyga kala duwan, muujisay codsatay medicament "Ofloxacin". Reviews ayaa sheegay in ay tahay mid aad u wanaagsan, waayo, caabuqyada neef-mareenka (pneumonia, boronkiitada), mareenka sare (otitis media, hogaga, jidiinka dhuunta, pharyngitis). Ka dhig ka daroogada ee jilicsan lesions unugyada, kalagoysyada, lafaha, maqaarka, mareenka biliary, kaadi mareenka (urethritis, cystitis), kalyaha (baylonfiritis), saabka caloosha, xubnaha taranka (orchitis, colpitis, epididymitis), xubnaha miskaha (salpingitis, prostatitis, cervicitis, endometritis, oophoritis, oo xuduudaheedu).

Sidoo kale daroogada waxtar u leh ureaplasmosis, chlamydia, jabtada. waxaa Isticmaal ka hortaga cudurada faafa ee dadka qaba xanuunada xaaladda difaaca jirka (oo ay ku jiraan neutropenia ah).

Foomka qiyaasta. Qaab-dhismeedka

sii daayo of medicament waa qaab Kiniin-dahaarle qaab wareega biconvex caddaan ama ku dhowaad caddaan dahaarka leh. The cross dareemi qeybaha laba layers, mid ka mid ah taas oo uu leeyahay towns ah hurdi. qayb firfircoon u dhaqmo sida ofloxacin. Mid ka mid ah kiniin ku jira tiro ka mid ah 200 ama 400 mg. waxyaabaha yaryar yihiin primelloza (croscarmellose sodium), cellulose mikrokristallin, Aerosil (Kolloidol Silicon dioxide), silica titania, povidone, methylcellulose hydroxypropyl (hypromellose), Rusheyn kartaa, milmahayn magnesium, tones polyetylen 4000 (macrogol). Faa'iidada A weyn ee daroogada "Ofloxacin" ah - qiimaha. Kiniiniyada ka kooban 200 mg oo ah walaxda firfircoon yihiin celcelis ahaan 16-20 rubles 10 gogo ', iyo kuwa ay ku jiraan 400 oo milligram ofloxacin, ku kici doona oo ku saabsan 50-55 rubles 10 gogo'.

"Ofloxacin" daawo. Tilmaamaha loogu isticmaalo

Kiniiniyada waa in ay cabaan ka hor ama ka dib cuntada ka. Waa in ay la wada liqo, oo aan xanjo, oo biyo cabbo tiro yar. qiyaasta waa in si gaar ah u doortay ku xiran tahay darnaanta cudurka, deegaamaynta ah ee cudurka, xaaladda guud ee bukaan-socodka, shaqada kelyaha, beerka, iyo dareenka bakteeriyada.

Sida caadiga ah, daaweynta "ofloxacin" waxaa loo sameeyey toddoba ilaa toban maalmood. Adult maalin qoray qaadashada of laba boqol, lix boqol oo milligram laba jeer maalintii. Qiyaasta lagu kordhin karaa ilaa sideed milligram in ay dhacdo cudur halis ah, ama haddii bukaanku waa xad dhaaf. Qiyaas yar oo afar milligram la qaadi karaa mar, fiican in aroortii.

Bukaanka qaba shaqada kelyaha oo yaraada mar ma qaadan kartaa in ka badan laba boqol oo miligaraam oo ah daroogada, qiyaasta ugu badan ee maalin kasta ee kala dhantaalan, cagaarshowga - afar boqol oo milligram. Ka dib markii lumis ee calaamadaha iyo caadi ah heerkulka, xataa laba ama saddex maalmood waa in ay sii wadaan therapy.

Dhibaatooyinka ay keento. Kurtumm

Ma bukaan oo dhan daroogada "Ofloxacin" si fiican loo dulqaatay. Reviews dadka qaar ka mid ah waxaa ku jira macluumaad in daawada keena madax xanuunnada, lalabo, matag, shuban, gariir, kabuubyo ah jirka. On qayb ka mid ah habka dheefshiidka laga yaabaa in la horumariyo sida calool xanuun, gastralgia, dibiro, joonis cholestatic, anorexia, hyperbilirubinemia, enterocolitis pseudomembranous, iyo habka dareemayaasha - la'aanta dhaqdhaqaaqa, casiraad, riyooyin aad u daran, reactions waallida, caro, welwel, wareer, cabsi-cuqdadeedka, dhalanteed, niyad-jabka.

Intaa waxaa dheer, waxaa jira halis ah xadgudubyo nidaamka motor ah (arthralgia, gaaray bowdada, myalgias), dareenka (xanuunada dhadhanka, midabada, maqalka, dheelitirka, urta), habka vascular iyo qalbigaba (hoos u cadaadiska dhiigga, tachycardia), maqaarka (dermatitis, dhibic hemorrhage, finan papular), ee hematopoiesis (Torombositobiiniya, dhiig yari, leukopenia). Ka dib markii la helo "Ofloxacin" daroogada (dib u eegista this xaqiijin), mararka qaarkood waxa ay u muuqataa maqaarka cuncun, bronchospasm, urtikaria.

sababo

Qaadashada medicament Reebay dulqaad ofloxacin iyo taagayo kale fluoroquinolone, in ay dhacdo deficiency of dehydrogenase glucose-6-phosphate, qalalka, lesions ee seedaha ah, yareynta marinka qalalka. Intaa waxaa dheer, in aadan qaadan kartaa daawada "Ofloxacin" haweenka uurka leh iyo kuwa nuujinaya, caruurta da'doodu ka yar tahay siddeed iyo toban. Iyadoo diyaarinta taxadir waxaa loogu xanuunada wareegga dhiigga ee maskaxda, atherosclerosis vascular cerebral, kelyaha ee chronic habdhiska dabeecadda lesions organic.

Medicament "Ofloxacin" at ureaplasma ah. Reviews

Waxa ugu muhiimsan waa in dadka ku odhan, isticmaalaan wax soo saarka - waa uu saamayn deg deg ah. Bukaan-socodka sheegaan in natiijadu waa dareemi horeba maalinta seddexaad ama afaraad. Laakiin waxaa lagama maarmaan ah si uu ugu digo in tani micnaheedu ma aha bilawga daawo. bukaanka kuwa joojiyay inuu cabbo kiniin, oo aan dhex marayay koorso buuxda, ka dibna mar kale cudurka ureaplasmosis, sababtoo ah bakteeriyada aan la gabi ahaanba ka reebtay.

ganaaxyada

Marka pneumonia xanaajiyeen by pneumococcus, daroogada loo baahnayn. Sidoo kale, waxa aan la tilmaamay lagu daaweyn jiray qumanka ba'an. Waxaa lagama maarmaan ah in la joojiyo daawada haddii ku saabsan asalka ah ee uu oggolaanshaha la kulmaan dareen xaasaasi ah, disorder habdhiska, ulcerös pseudomembranous. Haweenka codsanaya macnihiisu yahay "Ofloxacin", waxaa laguma talinayo in la isticmaalo tampons, maxaa yeelay, haddii ay taasi ku jiro halis kordhaysa oo ah horumarinta cabeebka.